Membranoproliferative glomerulonephritis and a rare bleeding disorder: factor X deficiency

Abstract

Factor X (FX) deficiency is a rare hereditary coagulation disorder. This is the first case report on the association of FX deficiency and membranoproliferative glomerulonephritis (MPGN) type I. The patient, a 17-year-old male, presented with edema, hypertension, and microscopic hematuria, followed by a mild upper respiratory tract infection. Laboratory tests revealed: serum creatinine 1.6 mg/dl, serum albumin 2.80 g/dl, C3 16 mg/dl and proteinuria (1,800 mg/day). The renal biopsy showed MPGN type I. The coagulation profile prior to percutaneous renal biopsy revealed prolonged prothrombin time and activated partial thromboplastin time values. The patient was given fresh frozen plasma and vitamin K before the biopsy. Further evaluation showed the functional activity of FX was 7% of the norm. This case emphasizes the need for routine coagulation screening before percutaneous renal biopsy.

Alteración De La Coagulación Y Microhematuria Persistente en Un Varón De 17 Años

“…It is worth mentioning the question of the association between nephropathy and factor X deficiency. A search in Pubmed returned only one article which described the case of a patient with membranoproliferative glomerulonephritis and factor X deficiency 9 . There is no genetic disease described which associates both pathologies and, therefore, we believe that there is no such association, and that it is a casual finding when studying the coagulation of a patient with hematuria.…”