Membranoproliferative glomerulonephritis complicating<i>Propionibacterium acnes</i>infection

Corner, A. H.; Kaartinen, Kati; Aaltonen, Sari; Räisänen-Sokolowski, Anne; Helin, Heikki; Honkanen, Eero

doi:10.1093/ckj/sfs165

Cited by 3 publications

(1 citation statement)

References 21 publications

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“…Bacterial endocarditis is associated with several types of kidney injuries, the commonest being septic emboli and glomerulonephritis [ 1 , 12 ]. Glomerulonephritis was found in 26% of specimens in a study combining biopsy and necropsy cases [ 1 ].…”

Section: Discussionmentioning

confidence: 99%

Gemella sanguinis endocarditis with c-ANCA/anti-PR-3-associated immune complex necrotizing glomerulonephritis with a 'full-house' pattern on immunofluorescence microscopy

Rousseau-Gagnon

Riopel

Desjardins

et al. 2013

Clinical Kidney Journal

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A 67-year-old man was evaluated for haematuria, with a rising creatinine level from 88 to 906 µmol/L and positive c-anti-neutrophil cytoplasm antibody (ANCA)/anti-proteinase 3 (anti-PR3). A kidney biopsy revealed necrotizing glomerulonephritis with a ‘full-house’ pattern on immunofluorescence microscopy. Echocardiography and blood cultures growing Gemella sanguinis diagnosed endocarditis. Dialysis was required for a month. Three months later, following valve replacement, glucocorticoids and 2 months of antibiotic therapy, the creatinine level decreased to 62 µmol/L and c-ANCA/anti-PR3 disappeared. This first case of c-ANCA/anti-PR3 positive glomerulonephritis with a ‘full-house’ immunofluorescence pattern due to bacterial endocarditis underlines the importance of ruling out infection with ANCA positivity or kidney biopsy suggestive of lupus nephritis.

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Section: Discussionmentioning

confidence: 99%

Gemella sanguinis endocarditis with c-ANCA/anti-PR-3-associated immune complex necrotizing glomerulonephritis with a 'full-house' pattern on immunofluorescence microscopy

Rousseau-Gagnon

Riopel

Desjardins

et al. 2013

Clinical Kidney Journal

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28/m mit Dyspnoe bei leichter Belastung

Girndt,

Markau

2024

Nephrologie

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Delayed Manifestation of Shunt Nephritis: A Case Report and Review of the Literature

Babigumira

Huang

Werner

et al. 2017

Case Reports in Nephrology

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We present an unusual case of shunt nephritis in a 39-year-old male who presented 21 years after placement of a ventriculoperitoneal (VP) shunt. He complained of fevers, headaches, dizziness, and urticarial plaques on arms, trunks, and legs and was found to have anemia, low complement levels, elevated serum creatinine, proteinuria, and new onset microhematuria. Blood and urine cultures were negative. Renal biopsy showed features of acute tubulointerstitial nephritis attributed to vancomycin use. Glomeruli showed increased mesangial hypercellularity and segmental endocapillary proliferation. Immunofluorescence showed focal IgM and C3 staining. Electron microscopy revealed small subendothelial electron-dense deposits. Symptoms and renal insufficiency appeared to improve with antibiotic therapy. He was discharged and readmitted 2 months later with similar presentation. CSF grew Propionibacterium acnes and shunt hardware grew coagulase-negative Staphylococcus. He completed an intravenous antibiotic course and was discharged. On 1-month follow-up, skin lesions persisted but he was otherwise asymptomatic. Follow-up labs showed significant improvement. We did a brief systematic review of the literature on shunt nephritis and report our findings on 79 individual cases. In this review, we comment on the presentation, lab findings, pathological features, and management of this rare, potentially fatal, but curable disease entity.

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Membranoproliferative glomerulonephritis complicatingPropionibacterium acnesinfection

Cited by 3 publications

References 21 publications

Gemella sanguinis endocarditis with c-ANCA/anti-PR-3-associated immune complex necrotizing glomerulonephritis with a 'full-house' pattern on immunofluorescence microscopy

Gemella sanguinis endocarditis with c-ANCA/anti-PR-3-associated immune complex necrotizing glomerulonephritis with a 'full-house' pattern on immunofluorescence microscopy

28/m mit Dyspnoe bei leichter Belastung

Delayed Manifestation of Shunt Nephritis: A Case Report and Review of the Literature

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