Membranoproliferative Glomerulonephritis: Correlations between Immunological and Histological Findings

Zucchelli, P; M, Sasdelli; Cagnoli, L; Donini, U; Casanova, S.; Rovinetti, C

doi:10.1159/000180753

Cited by 6 publications

(2 citation statements)

References 14 publications

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“…C1q, C4, and immunoglobulins such as IgG and IgM are also detected in many, if not most, cases [4,5]. This corresponds to the prominent subendothelial and mesangial immune complex localization observed by electron microscopy.…”

Section: Introductionmentioning

confidence: 88%

A case of membranoproliferative glomerulonephritis developed over twenty years with three different findings of renal pathology

et al. 2012

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A 31-year-old woman with proteinuria, hypocomplementemia, rheumatoid factor, and high serum polyclonal IgM concentration was admitted to our hospital for renal biopsy. She had a past history of two renal biopsies. When she was 12 years old, she developed proteinuria, microscopic hematuria, and hypocomplementemia. She was diagnosed as having 'IgM nephropathy' based on minor glomerular abnormalities as determined by light microscopy and IgM and C3 deposition in the mesangial region by immunofluorescence microscopy at the first biopsy. Despite corticosteroid treatment, her proteinuria did not improve and she discontinued regular outpatient checkups. When she was 29 years old and pregnant, she developed preeclampsia and, after delivery, a second renal biopsy was implemented. She was diagnosed as having progressed 'IgM nephropathy' with endotheliosis induced by preeclampsia. She was treated with angiotensin II receptor blocker and her proteinuria diminished; however, 1 year after the delivery, she developed proteinuria again, along with microscopic hematuria and hypocomplementemia. A third renal biopsy was conducted at 31 years of age and she was diagnosed as having membranoproliferative glomerulonephritis (MPGN) type I on the basis of diffuse mesangial proliferation, endocapillary hypercellularity with double contour of the capillary wall, and lobular formation in glomeruli, as determined by light microscopy. Immunofluorescence staining demonstrated deposits of C3, C4, C1q, and IgM in the mesangial region and capillary wall. She underwent corticosteroid therapy followed by normalization of urinalysis and serum complement level. Although she had initially been diagnosed with 'IgM nephropathy', she was finally diagnosed with secondary MPGN and was successfully treated by corticosteroid therapy.

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Section: Introductionmentioning

confidence: 88%

A case of membranoproliferative glomerulonephritis developed over twenty years with three different findings of renal pathology

et al. 2012

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“…In all patients renal tissue was obtained by light, electron and immunofluorescence microscopy using standard methods as pre viously reported [4],…”

Section: Methodsmentioning

confidence: 99%

Lymphocyte Subpopulations in Minimal-Change Nephropathy

Sasdelli

Rovinetti

Cagnoli

et al. 1980

Nephron

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It has been suggested that minimal-change nephropathy (MCN) may be related to a disorder of cell-mediated immunity. Lymphocyte cell-surface markers (E and EAC rosettes) and functional markers (mitogenic response to PHA, Con A and PWM) were examined in 13 patients with MCN and nephrotic syndrome (NS) and in 13 patients with MCN in remission compared to 20 patients with membranous glomerulonephritis (MG) and NS, and 20 normal controls. None of the patients received medication at the time of the study. The response to various mitogens of MCN with NS was significantly reduced, while MCN in remission and MG had mean values of the mitogenic response not significantly different in respect to normal controls. Lymphocyte hyporeactivity in autologous plasma was associated, in approximately 50% of the patients with MCN and NS, to a normal lymphocyte response in homologous plasma and to the presence of an inhibitory effect of MCN plasma on normal lymphocytes. Also, the percentage of E rosettes was reduced, while the percentage of EAC rosettes was increased. The defect of T cells was not related to the degree of the NS. In 7 patients, studied at the onset of NS and afterwards in remission, the functional and numerical lymphocyte deficit disappeared during recovery. There is evidence that MCN is associated with a functional disorder of T cells which may be related to the presence of a humoral inhibiting factor.

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Immunopathology of membranoproliferative glomerulonephritis with subendothelial deposits (Type I MPGN)

Lévy

Gubler

Sich

et al. 1978

Clinical Immunology and Immunopathology

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Membranoproliferative Glomerulonephritis: Correlations between Immunological and Histological Findings

Cited by 6 publications

References 14 publications

A case of membranoproliferative glomerulonephritis developed over twenty years with three different findings of renal pathology

A case of membranoproliferative glomerulonephritis developed over twenty years with three different findings of renal pathology

Lymphocyte Subpopulations in Minimal-Change Nephropathy

Immunopathology of membranoproliferative glomerulonephritis with subendothelial deposits (Type I MPGN)

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