Membranous Glomerulonephritis Associated With Hepatitis C Virus Infection in Renal Transplant Patients1,2

Jm, Morales; Pascual-Capdevila, J.; Jm, Campistol; G, Fernandez-Zatarain; Ma, Muñoz; Andrés, Amado; Praga, Manuel; Ma, Martinez; Usera, Gabriel; Fuertes, A; Oppenheimer, F.; P, Artal; Darnell, A; Jl, Ródicio

doi:10.1097/00007890-199706150-00017

Cited by 133 publications

(70 citation statements)

References 22 publications

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“…105 HCV infection also has been associated with post-renal transplantation recurrent or de novo MGN. 106 Last, HCV infection has been found in a greater percentage of patients with compared with without transplant glomerulopathy and also has been associated with the development of an anticardiolipinrelated allograft thrombosis. 107,108 …”

Section: Recurrent Renal Diseasementioning

confidence: 99%

Identification of patients best suited for combined liver[ndash ]kidney transplantation: Part II

Davis

Gonwa

Wilkinson

2002

Liver Transplantation

117

105

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Liver-kidney transplantation (LKT) should be reserved for those recipients with primary disease affecting both organs. However, increasing transplant list waiting times have increased the development and duration of acute renal failure before liver transplantation. Furthermore, the need for posttransplant calcineurin inhibitors can render healing from acute renal failure difficult. Because of the increasing requests for and controversy over the topic of a kidney with a liver transplant (OLT) when complete failure of the kidney is not known, the following article will review the impact of renal failure on liver transplant outcome, treatment of peri-OLT renal failure, rejection rates after LKT, survival after LKT, and information on renal histology and progression of disease into the beginnings of an algorithm for making a decision about combined LKT. (Liver Transpl 2002;8:193-211.)

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Section: Recurrent Renal Diseasementioning

confidence: 99%

Identification of patients best suited for combined liver[ndash ]kidney transplantation: Part II

Davis

Gonwa

Wilkinson

2002

Liver Transplantation

117

105

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“…[25][26][27][28][29]31 HCV and KT HCV infection is the primary cause of liver disease in KT recipients 32 ; however, it has also been associated with important extrahepatic manifestations that contribute to increased morbidity and mortality after transplantation. 33 HCVinfected recipients are at increased risk of de novo and recurrent membranous nephropathy, membranoproliferative GN, [34][35][36] and transplant glomerulopathy. 37 Infection with HCV has also been associated with an increased risk for insulin resistance and diabetes mellitus in waitlisted candidates and kidney recipients, similar to that reported for the general population.…”

Section: Hcv In Patients With Kidney Diseasementioning

confidence: 99%

Hepatitis C Virus Infection in Chronic Kidney Disease

Ladino

Pedraza

Roth

2016

JASN

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Soon after the hepatitis C virus (HCV) was identified in 1989, it was recognized that the prevalence of infection in patients with ESRD far exceeded that in the general population. Infection with HCV predisposes to the hepatic complications of cirrhosis and hepatocellular carcinoma. However, important extrahepatic manifestations include immune complex glomerular disease, accelerated progression of CKD, increases in cardiovascular event risk, and lymphoproliferative disorders. Advances in understanding the molecular biology of HCV have ushered in a new era in the treatment of this infection. Second generation direct-acting antiviral agents have revolutionized therapy, with sustained virologic response rates (undetectable viral load 12 weeks after completing therapy) of .90% in most patients. Studies using direct-acting antivirals in patients with CKD and those on dialysis are showing excellent safety and efficacy as well. In this context, it is imperative that nephrologists become familiar with this literature, reviewed here, so that the important decisions, including which patients should be treated and the optimal timing to initiate therapy, are vetted in association with the compounding issues of CKD, ESRD, and kidney transplantation.

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“…The most frequent glomerular lesions observed among HCV-positive kidney transplant recipients are cryoglobulinemic or noncryoglobulinemic memb ranoproliferative glomerulonephritis (MPGN) 27 and membranous glomerulonephritis (MGN) 28 and to a lesser extent transplant glomerulopathy, anticardiolipin-related thrombotic microangiopathy, 29 and fibrillary glomerulonephritis. 30 The pathogenesis of MPGN and MGN may be due to deposition of immunocomplexes containing viral RNA in the glomerulus, 31 as confirmed by detection of viral antigens by immunohistochemistry.…”

Section: Glomerular Lesionsmentioning

confidence: 99%

“…Posttransplant cryoglobulinemic and noncryoglobulinemic MPGN and MGN associated with HCV infection contribute to the development of graft failure. 40 Type 1 MPGN is associated with accelerated loss of the graft, 28 whereas, with MGN, the clinical course and the development of renal failure appear to be similar in patients with and without HCV infection. 45 Fabrizi and associates 21 concluded in their meta-analysis (4 of 8 studies) that the presence of anti-HCV antibodies was an independent risk factor for graft failure (RR, 1.56).…”

Section: Effect Of Hepatitis C Virus Infection On Graft Survivalmentioning

confidence: 99%

Untitled

Gheith

Halim²,

Othman³

et al. 2017

Exp Clin Transplant

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Chronic hepatitis C virus infection is a global health problem, especially among renal transplant recipients. Herein, we present an overview of hepatitis C virus among renal transplant patients, with a focus on some updated aspects concerning types of viral genotypes, methods of diagnosis, the effects of renal transplant on hepatitis C virus infection, and summary of hepatitis C virus-related complications after renal transplant. We also discuss patient and graft survival rates and the present and future therapeutic options with special focus on new antiviral and possible interactions with immunosuppressive medications.

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Membranous Glomerulonephritis Associated With Hepatitis C Virus Infection in Renal Transplant Patients1,2

Cited by 133 publications

References 22 publications

Identification of patients best suited for combined liver[ndash ]kidney transplantation: Part II

Identification of patients best suited for combined liver[ndash ]kidney transplantation: Part II

Hepatitis C Virus Infection in Chronic Kidney Disease

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