Membranous Nephropathy Associated with Hypocomplementemic Urticarial Vasculitis: Report of Two Cases and a Review of the Literature

Kobayashi, Shuzo; Nagase, Mitsumasa; Hidaka, Sumi; Arai, Takami; Ikegaya, Naoki; Hishida, Akira; Honda, Nishio

doi:10.1159/000187758

Cited by 39 publications

(16 citation statements)

References 11 publications

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“…Nephrotic syndrome has also been reported. Renal biopsies have been described in at least 20 cases, with a predominance of mesangial proliferative lesions, followed in frequency by focal proliferative, membranoproliferative, and membranous lesions [6]. Our patient's renal biopsy demonstrated a membranoproliferative glomerulonephritis, with membranous features on electron microscopy.…”

Section: Discussionmentioning

confidence: 56%

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Hypocomplementemic urticarial vasculitis: report of a pediatric case

Cadnapaphornchai

Saulsbury

Norwood

2000

Pediatric Nephrology

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Hypocomplementemic urticarial vasculitis syndrome (HUVS) is well described in adults but is quite rare in children. We report a pediatric case of HUVS initially diagnosed as juvenile rheumatoid arthritis and then as Henoch-Schönlein purpura. Beginning at 3 years of age, our patient developed polyarthritis with hypocomplementemia. She subsequently experienced an intermittent purpuric rash beginning at age 4 years, and she continued to have episodic arthritis and rash for years. Hematuria and proteinuria were noted at 12 years of age; renal biopsy revealed membranoproliferative glomerulonephritis with membranous features. Serum complement evaluation revealed activation of the classical pathway, consistent with HUVS. Therapy with oral dapsone led to improvement in proteinuria. HUVS should be considered in the differential diagnosis of pediatric patients with glomerulonephritis, urticarial rash, arthritis/arthralgias, and obstructive pulmonary disease.

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Section: Discussionmentioning

confidence: 56%

“…Urinalysis may be normal or can demonstrate hematuria and/or proteinuria. In a literature review, Kobayashi et al [6] found that hematuria and/or proteinuria occurred in 16 of 54 patients. Nephrotic syndrome has also been reported.…”

Section: Discussionmentioning

confidence: 99%

Hypocomplementemic urticarial vasculitis: report of a pediatric case

Cadnapaphornchai

Saulsbury

Norwood

2000

Pediatric Nephrology

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“…This paediatric experience is in contrast to the ®nd-ings in adults who mostly display mild renal disease [7,11,13,15]. The reason for this discrepancy remains to be elucidated.…”

Section: Discussionmentioning

confidence: 80%

Rapidly progressive glomerulonephritis in a boy with hypocomplementaemic urticarial vasculitis

Renard

Wouters

Proesmans

1998

European Journal of Pediatrics

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“…Kobayashi et al [11]found renal involvement in 78 patients with HUVS from 1973 to 1990. Sixteen patients (20%) had abnormal urinalysis.…”

Section: Discussionmentioning

confidence: 99%

“…But, in all cases, deposits of immunoglobulins and complements were recognized, suggesting that renal injury in HUVS is immune-mediated. In Japan, to our knowledge, there have been only 4 cases of adult HUVS [9, 11, 14], of which 3 had membranous nephropathy, while the other case exhibited features similar to those of membranous nephropathy (subepithelial dense deposits shown by electron microscopy).…”

Section: Discussionmentioning

confidence: 99%

Membranoproliferative Glomerulonephritis Associated with Hypocomplementemic Urticarial Vasculitis after Complete Remission of Membranous Nephropathy

Saeki

Ueno²,

Shimada³

et al. 2001

Nephron

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A 49-year-old-man developed proteinuria in 1978. He was diagnosed as having membranous nephropathy by renal biopsy and was treated with prednisolone. The proteinuria disappeared completely and the treatment was stopped. In 1995, after complete remission, he developed nephrotic syndrome with chronic urticaria and hypocomplementemia. Renal biopsy revealed membranoproliferative glomerulonephritis (type I) and skin biopsy showed leukocytoclastic vasculitis, which was compatible with hypocomplementemic vasculitis syndrome. Steroid therapy was very effective.

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Membranous Nephropathy Associated with Hypocomplementemic Urticarial Vasculitis: Report of Two Cases and a Review of the Literature

Cited by 39 publications

References 11 publications

Hypocomplementemic urticarial vasculitis: report of a pediatric case

Hypocomplementemic urticarial vasculitis: report of a pediatric case

Rapidly progressive glomerulonephritis in a boy with hypocomplementaemic urticarial vasculitis

Membranoproliferative Glomerulonephritis Associated with Hypocomplementemic Urticarial Vasculitis after Complete Remission of Membranous Nephropathy

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