Membranous Nephropathy Associated With Renal Cell Carcinoma

Stein, H; Yudis, Melvin; Sirota, Robert A.; Snipes, Edward R.; Gronich, J H

doi:10.1016/s0272-6386(12)70332-3

Cited by 10 publications

(5 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, only four cases of MGN with renal cell carcinoma have been described previously [4, 5, 6, 8]. Several studies have suggested that glomerular injury in MGN associated with malignancy is caused by immune complexes composed, at least in part, of some tumor-associated antigens [3, 9, 10, 11, 12, 13, 14].…”

Section: Resultsmentioning

confidence: 99%

“…Carcinomas associated with MGN commonly involve the lung and gastrointestinal tract [1, 2, 3, 4]. On the other hand, MGN associated with renal cell carcinoma is rare and there are only a few reports in the literature describing the association [4, 5, 6, 7, 8]. We present here a case of renal cell carcinoma associated with MGN, which resulted in a transient amelioration of the nephrotic syndrome after excision of the tumor.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Membranous Glomerulonephritis Associated with Renal Cell Carcinoma: Failure to Detect a Nephritogenic Tumor Antigen

Togawa

Yamamoto²,

Suzuki³

et al. 2002

Nephron

View full text Add to dashboard Cite

A 57-year-old man with renal cell carcinoma associated with membranous glomerulonephropathy (MGN) developed a transient amelioration of the nephrotic syndrome after excision of the tumor. We tried to identify a nephritogenic tumor antigen using the immunoblotting technique in this patient with MGN, since previous studies examined the interaction between tumor antigens and IgG eluted from the kidney tissue using immunofluorescence or immunodiffusion techniques, and no studies have identified the specific tumor antigen with the immunoblotting method. In the present study, no significant immunoreactivity was noted between the IgG eluted from renal cortical tissues of the patient and renal cell carcinoma proteins. Further studies are necessary to establish the pathogenic mechanism of MGN associated with malignancy.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Membranous Glomerulonephritis Associated with Renal Cell Carcinoma: Failure to Detect a Nephritogenic Tumor Antigen

Togawa

Yamamoto²,

Suzuki³

et al. 2002

Nephron

View full text Add to dashboard Cite

show abstract

“…Since membranous nephropathy associated with malignancy has been attributed to tumor antigen-antibody immune complex formation, the cancer related antigens have been identified in immune complex in some cases including PSA in prostate cancer, CEA in gastrointestinal cancer [34]. Renal cell carcinoma has been reported to be associated with membranous nephropathy [35][36][37][38][39][40][41][42][43], but its prevalence is lower compared with gastrointestinal cancer and lung cancer (Table 3). As antibodies against phospholipase A2 receptor antibody have been identified in 70 % of patients with primary membranous nephropathy [44], a diagnosis of secondary membranous nephropathy should be considered when it is negative.…”

Section: Membranous Nephropathy and Renal Cell Carcinomamentioning

confidence: 99%

Paraneoplastic Glomerulopathy Associated with Renal Cell Carcinoma

Tojo¹

2013

Renal Tumor

View full text Add to dashboard Cite

Figure . However, when VHL protein is lost in clear cell renal cell carcinoma, various cytokines and growth factors induced by HIFare enhanced vascular endothelial growth factor VEGF which stimulates angiogenesis of carcinoma, platelet-derived growth factor PDGF and transforming growth factor alpha TGF-, which lead to tumor growth, glucose transporter GLUT-and carbonic anhydrase IX CA IX , which leads to tumor cell survival in an acidic environment [ -]. NF-kB activity is also regulated by VHL protein, and cytokine-inducible transcription factors including NF-kB and STAT are activated in renal cell carcinoma [ -]. Renal cell carcinoma tissue and cell lines of the tumor express mRNA of IL-and IL-receptor [ , ], which may play a role in cancer cell growth in an autocrine or paracrine manner. Renal Tumor

show abstract

“…The reason why RCC is rarely associated with MN is unknown; however, only four cases have been reported to date. [3][4][5][6] Recently we experienced a patient with MN complicated with RCC (Table 1), in whom noninvasive diagnosis was difficult. Definitive diagnosis was made histologically through examination of a biopsy specimen.…”

Section: Introductionmentioning

confidence: 99%

Membranous nephropathy complicated by renal cell carcinoma

Fujita

Kashiwagi

Takei

et al. 2004

Clinical and Experimental Nephrology

View full text Add to dashboard Cite

We experienced a patient with membranous nephropathy (MN) and renal cell carcinoma (RCC). Although MN is known to be commonly associated with malignant tumors, association with RCC is rare. In our patient, no malignant focus was found in the major organs examined, except for a small lesion in the right kidney. Diagnosis of a small RCC (1.6 x 1.6 cm), which was made by renal biopsy and histology, was impossible by other, imaging, methods. As surgical treatment for the patient, laparoscopic partial nephrectomy was performed successfully, alleviating the symptoms of nephrotic syndrome for up to 21 months.

show abstract

Membranous Nephropathy Associated With Renal Cell Carcinoma

Cited by 10 publications

References 1 publication

Membranous Glomerulonephritis Associated with Renal Cell Carcinoma: Failure to Detect a Nephritogenic Tumor Antigen

Membranous Glomerulonephritis Associated with Renal Cell Carcinoma: Failure to Detect a Nephritogenic Tumor Antigen

Paraneoplastic Glomerulopathy Associated with Renal Cell Carcinoma

Membranous nephropathy complicated by renal cell carcinoma

Contact Info

Product

Resources

About