Memorable messages that adoptees receive throughout development may have lasting impacts on their well-being, identity development, and relationships. Given historical and current adoption practices that link adoption and Christianity, more research is needed to examine the memorable messages that adoptees received while being raised in these religious contexts. Using a qualitative approach grounded in the communicated sense-making model, 41 adult adoptees were interviewed to identify memorable messages they heard while growing up in Christian adoptive homes, the communicators of messages, and their interpretations of the messages as children and adults. Results revealed a range of memorable messages communicated primarily by adoptive parents and church members, including that the adoptee was chosen by God, that the adoption was part of God’s plan, and that they were saved/rescued. Common childhood interpretation themes included accepting the messages, questioning belonging, and complying/people pleasing. Adult interpretations were generally more critical, including that the messages glossed over trauma and grief and implied negative views of first family/culture. These findings add to the literature in adoptive family communication by taking into account the religious undertones of many adoption-based messages and contribute to the broader literature on memorable messages by identifying participants’ progression of sense-making in interpreting these messages.