Background: This study was performed to identify the mediating effect of alcohol expectancy and moderating effect of coping response on the relation between university students' stress and drinking problem. Methods: Data collected from 264 university students' self-report questionnaire, including life daily stress, alcohol expectancy, coping response, drinking problem were analyzed. Results: The mediating effect of alcohol expectancy was significant (=.26, p<.001). Although, the moderating effect of approach coping response was not significant, the moderating effect of avoidance coping response was significant (=.12, p<.01). Conclusions: These results suggest that treatment and intervention for drinking problems of university students' must pay attention on alcohol expectancy and try to decrease the preference of avoidance coping response.