Memory activation enhances EEG abnormality in mild cognitive impairment

Hiele, Karin van der; Vein, Alla A.; Kramer, C. G. S.; Reijntjes, R.; Buchem, Mark A. van; Westendorp, Rudi G.J.; Bollen, E.; Dijk, J. Gert van; Middelkoop, Huub A. M.

doi:10.1016/j.neurobiolaging.2005.11.006

Cited by 50 publications

(23 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Increased and decreased alpha activity are thought to reflect inhibitory and excitatory brain processes, respectively (for review, see Klimesch, Sauseng, & Hanslmayr, 2007). It has been suggested that alpha band desynchronization may represent encoding stimuli into working memory (Gomarus, Althaus, Wijers, & Minderaa, 2006; Stipacek, Grabner, Neuper, Fink, & Neubauer, 2003) and, less alpha desynchronization has been related to impaired memory performance in older adults with mild cognitive impairment (van der Hiele, et al, 2007). Moreover, greater alpha desynchronization has been linked to enhanced memory performance (Doppelmayr, Klimesch, Hodlmoser, Sauseng, & Gruber, 2005; Klimesch, Doppelmayr, Pachinger, & Ripper, 1997).…”

Section: Discussionmentioning

confidence: 99%

Delays in neural processing during working memory encoding in normal aging

2010

View full text Add to dashboard Cite

Declines in neural processing speed have been proposed to underlie a broad range of cognitive deficits in older adults. However, the impact of delays in neural processing during stimulus encoding on working memory (WM) performance is not well understood. In the current study, we assessed the influence of aging on the relationship between neural measures of processing speed and WM performance during a selective delayed-recognition task for color and motion stimuli, while electroencephalography (EEG) was recorded in young and older adults. A latency delay was observed for the selection negativity (SN) and alpha band activity (measures of attentional allocation) in older adults during WM encoding of both motion and color stimuli, with the latency and magnitude of the SN predicting subsequent recognition performance. Furthermore, an age-related delay in the N1 latency occurred specifically during the encoding of color stimuli. These results suggest that the presence of both generalized feature-based and feature-specific deficits in the speed of selective encoding of information contributes to WM performance deficits in older adults.

show abstract

Section: Discussionmentioning

confidence: 99%

Delays in neural processing during working memory encoding in normal aging

2010

View full text Add to dashboard Cite

show abstract

“…However, differences between typical and MCI groups are not always detected at rest. For example, in a study of EEG power differences between normal and MCI groups, differences were detected during working memory tasks but not at rest [33]. For this reason, we chose to record EEG during a memory task.…”

Section: Introductionmentioning

confidence: 99%

Neural Correlates of True and False Memory in Mild Cognitive Impairment

et al. 2012

View full text Add to dashboard Cite

The goal of this research was to investigate the changes in neural processing in mild cognitive impairment. We measured phase synchrony, amplitudes, and event-related potentials in veridical and false memory to determine whether these differed in participants with mild cognitive impairment compared with typical, age-matched controls. Empirical mode decomposition phase locking analysis was used to assess synchrony, which is the first time this analysis technique has been applied in a complex cognitive task such as memory processing. The technique allowed assessment of changes in frontal and parietal cortex connectivity over time during a memory task, without a priori selection of frequency ranges, which has been shown previously to influence synchrony detection. Phase synchrony differed significantly in its timing and degree between participant groups in the theta and alpha frequency ranges. Timing differences suggested greater dependence on gist memory in the presence of mild cognitive impairment. The group with mild cognitive impairment had significantly more frontal theta phase locking than the controls in the absence of a significant behavioural difference in the task, providing new evidence for compensatory processing in the former group. Both groups showed greater frontal phase locking during false than true memory, suggesting increased searching when no actual memory trace was found. Significant inter-group differences in frontal alpha phase locking provided support for a role for lower and upper alpha oscillations in memory processing. Finally, fronto-parietal interaction was significantly reduced in the group with mild cognitive impairment, supporting the notion that mild cognitive impairment could represent an early stage in Alzheimer’s disease, which has been described as a ‘disconnection syndrome’.

show abstract

“…The use of mental tasks improves the classification accuracy of subjects with normal aging, MCI and AD, with the hypothesis that there are pronounced differences between the cognitive tasks used for this purpose (Sneddon et al, 2005). In a memory activation task EEG power differences were revealed in the lower alpha band between MCI patients and controls, while in the resting conditions no such differences were observed (van der Hiele et al, 2007). Changes in event related desynchronization/synchronization (ERD/ERS) of alpha and beta rhythms with abnormal ERD/ERS in the frontolateral, centromedial and ipsilateral rolandic areas were found in AD patients (Babiloni et al, 2000).…”

Section: Introductionmentioning

confidence: 99%