Memory and attention after childhood brain tumors

Dennis, Maureen; Hetherington, Catherine; Spiegler, Brenda J.

doi:10.1002/(sici)1096-911x(1998)30:1+<25::aid-mpo4>3.0.co;2-a

Cited by 70 publications

(69 citation statements)

References 30 publications

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“…Eight of the 11 attention variables were significantly below than population averages. Consistent with previous studies of attention within pediatric brain tumor populations (Dennis et al 1998;Mulhern et al 2001;Mulhern et al 2004;Reddick et al 2003), patients' responses were slow and irregular. These attention deficits reflected slow processing speed and poor selective attention rather than impulsivity.…”

Section: Core Cognitive Abilitiessupporting

confidence: 92%

“…Studies that followed became increasingly specific in their aims and objectives. Protocols were designed to prospectively test hypotheses of age at treatment and radiation dose as risk factors, and patient groups became more homogeneous with respect to treatment and tumor type (Dennis et al 1998;Deutsch et al 1996;Mulhern et al 1998;Ris and Noll 1994;Silber et al 1992). …”

Section: Impact On Broad Spectrum Abilitiesmentioning

confidence: 99%

“…Intellectual and academic outcomes are considered distal markers that arise secondary to changes in underlying core cognitive skills (Mulhern and Palmer 2003;Palmer et al 2003;Palmer et al 2007). Impairments in foundational skills of broad memory, working memory, attention and information processing speed have also been reported (Dennis et al 1998;Kieffer-Renaux et al 2000;Mabbott et al 2008;Mulhern et al 2004;Nagel et al 2006;Reeves et al 2006;Schatz et al 2000;Spiegler et al 2004) and may be precursors to the observed declines in intellectual function and academic function.…”

Section: Core Cognitive Abilitiesmentioning

confidence: 99%

“…Therefore, at the present time these three core cognitive abilities remain grouped together (Figure 1, ovals) until causal relationships are identified. Difficulty with sustained attention may stem from an inability to hold mental representations in order to guide behavior, an ability associated with (Gathercole and Alloway 2006) or even causally related (Dennis et al 1998) to working memory. The association between processing speed and attention also needs further examination.…”

Section: A Proposed Conceptual Modelmentioning

confidence: 99%

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Neurodevelopmental impact on children treated for medulloblastoma: A review and proposed conceptual model

Palmer¹

2008

Dev Disabil Res Revs

116

131

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The population of survivors following diagnosis and treatment for medulloblastoma is thankfully on the rise. An increased focus on the quality of that survivorship has expanded the concept of cure to include efforts aimed at improving long-term cognitive outcome. It is well established in the literature that decline in overall intellect and academic performance is experienced by a majority of those undergoing treatment for pediatric medulloblastoma. This decline is believed to be secondary to decline in core cognitive abilities, which in turn are related to underlying damage to neuroanatomical substrates. A review of research on neurodevelopmental impacts following diagnosis and treatment for pediatric medulloblastoma is presented. Particular consideration is given to studies recently published that also reflect critical collaboration among those within the fields of neuropsychology and neuro-imaging. Results from the review are combined within a conceptual model upon which to guide future research and clinical efforts. Keywords medulloblastoma; cognitive deficits; brain tumor; model; processing speed; attention; working memory Callouts 1. Based on the knowledge derived from studies of long term outcomes, it is important to consider medulloblastoma, as well as other pediatric cancers, as a condition resulting in life long morbidities related to the treatment for, but separate from, the primary presenting disease. 2.Intellectual and academic outcomes are considered distal markers and secondary to changes in underlying core cognitive skills.3. While much of the research to date has focused on risk for deficits in cognitive function, attention should also be paid to resilience. 4.Consideration of the current literature on children diagnosed and treated for medulloblastoma reveals there is at least the start of a conceptual model illustrating the likely relationships between treatment, underlying

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Section: Core Cognitive Abilitiessupporting

confidence: 92%

Section: Impact On Broad Spectrum Abilitiesmentioning

confidence: 99%

Section: Core Cognitive Abilitiesmentioning

confidence: 99%

Section: A Proposed Conceptual Modelmentioning

confidence: 99%

See 2 more Smart Citations

Neurodevelopmental impact on children treated for medulloblastoma: A review and proposed conceptual model

Palmer¹

2008

Dev Disabil Res Revs

116

131

View full text Add to dashboard Cite

show abstract

“…The environment in schools is particularly demanding because of the need to attend to and integrate complex information in an often loud and distracting environment [10], resulting in an increased risk of dropping out of school, becoming a social outcast with psychological problems and difficulties finding a job and future employment [11]. Deficits in attention could also impact negatively on the effect and outcome of rehabilitation programmes designed to improve functioning [12].…”

Section: Introductionmentioning

confidence: 93%