Memory and executive functions in persons with type 2 diabetes: a meta‐analysis

Sadanand, Shilpa; Balachandar, Rakesh; Bharath, Srikala

doi:10.1002/dmrr.2664

Cited by 110 publications

(83 citation statements)

References 62 publications

(185 reference statements)

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“…There is thus an obvious need for more information about the possible early adverse effects of diabetes on cognitive functions. Numerous reviews and meta-analyses link type 2 diabetes to cognitive deficits and describe the multiple mechanisms underlying those deficits in older people (Awad, Gagnon, & Messier, 2004;Kodl & Seaquist, 2008;McGrimmon, Ryan, & Frier, 2012;Monette, Baird, & Jackson, 2014;Palta, Schneider, Biessels, Touradji, & Hill-Briggs, 2014;Reijmer, van den Berg, Ruis, Kappelle, & Biessels, 2010;Sadanand, Balachandar, & Bharath, 2015;Vincent & Hall, 2015). According to these studies, cognitive deficits in diabetes patients are most frequently evident in the domains of memory, executive functions and speed of information processing.…”

Section: Introductionmentioning

confidence: 99%

Type 2 Diabetes and Cognitive Functions in Middle Age: A Meta-Analysis

Pelimanni

Jehkonen

2018

J Int Neuropsychol Soc

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Objective: Type 2 diabetes mellitus has been linked with cognitive decrement and an increased risk of dementia in older people. Less is known about whether diabetes affects cognition at younger ages. The objective of this meta-analysis was to examine possible differences (effect sizes) in cognitive performance between middle-aged type 2 diabetic patients and healthy controls. Secondary aim was to examine whether age is related to the magnitude of effect sizes. Method: Electronic databases and lists of references of selected articles were used to search for studies examining type 2 diabetes and cognition in patients under age 65 compared to healthy controls. Twelve studies met the inclusion criteria. Standardized mean differences (Hedges's g) were calculated for main cognitive domains and their subdomains. Association between age and effect sizes was evaluated with meta-regression analyses. Publication bias and methodological quality of the studies were assessed. Results: Patients performed worse than controls in several cognitive functions. The largest differences were found in information processing speed (g=-0.68), attention/concentration (g=-0.55), executive functions (g=-0.51), and working memory (g=-0.51). There was no significance difference in visual memory (g=-0.15). Age was significantly related to the effect size in information processing speed, language, and verbal memory and visual memory. However, the direction of association varied across these cognitive domains. Conclusions:The results suggest that cognitive decrement in diabetes is not restricted to older people, but may begin to appear in middle age. More attention should be paid to early recognition and treatment of diabetes-related cognitive decrement in health care systems.

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Section: Introductionmentioning

confidence: 99%

Type 2 Diabetes and Cognitive Functions in Middle Age: A Meta-Analysis

Pelimanni

Jehkonen

2018

J Int Neuropsychol Soc

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“…A recent study in Japanese patients with T2D that also employed the MoCA test to evaluate cognitive function/ domains has shown that patients with diabetes and mild cognitive impairment had lower scores for frontal lobe function (attention, language and abstraction) and delayed recall (17). Moreover, a recent systematic review and meta-analysis of 15 studies (n=23796; 2370 with T2D) has confirmed that T2D is associated with impairment in memory and executive function (18). A longitudinal study with a 12-year follow-up reported that individuals with T2D presented accelerated cognitive decline, mainly in the information-processing speed, executive function and delayed word recall compared with subjects without diabetes (19).…”

Section: Discussionmentioning

confidence: 97%

Markers of cognitive impairment in patients with type 2 diabetes

Șular¹,

Huţanu²,

Voidăzan³

2016

Revista Romana De Medicina De Laborator

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Background. The study aimed to evaluate the correlations of cognitive function with metabolic, nutritional, hormonal and immunologic parameters in patients with type 2 diabetes (T2D), in order to identify markers of cognitive impairment. Material and methods. This cross-sectional study included 216 T2D patients and 23 healthy individuals (HC p: 0.004). T2D patients with cognitive dysfunction were significantly older and less formally educated (p < 0.0001). Age negatively correlated with MoCA scores p < 0.0001). T2D patients had significantly lower p < 0.0001). Serum Mg levels positively correlated with MoCA scores (0.24, 95%CI: 0.07, 0.39; p: 0.003) and with visuospatial/executive (0.30; 95%CI: 0.14, 0.45; p: 0.0002) and naming functions (0.18; 95%CI: 0.01, 0.34; p: 0.02

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“…In addition, factors such as long evolution of DM, elevated HbA1c levels, or history of insulin treatment are considered risk factors for the development of CIM. Previous work has demonstrated that Mexican-American participants with DM had a greater risk of dementia and CIM in comparison with non-diabetic participants [6][7][8] . Similarly, DM patients also have a higher risk of geriatric conditions, including dementia, disability, falls, and urinary incontinence 9 .…”

Section: Introductionmentioning

confidence: 97%

Geriatric Syndromes and Not Cardiovascular Risk Factors are Associated with Cognitive Impairment among Mexican Community-Dwelling Elderly with Type 2 Diabetes

Bello‐Chavolla

Aguilar-Salinas

Ávila-Funes

2017

RIC

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Background: The association of cognitive impairment and type 2 diabetes has been consistently shown in several studies, yet its association with geriatric syndromes has not been fully explored. Objective: To study the correlates of cognitive impairment among community-dwelling elderly with type 2 diabetes. Methods: Cross-sectional study of 135 diabetic persons aged 70 years or older participating in the Coyoacán Cohort Study in Mexico City. Baseline data included chronic illnesses, geriatric syndromes, and diabetes-related variables. The lowest quartile in both the Mini-Mental State Examination and the Isaacs Set Test, according to age and schooling, was used to identify participants with cognitive impairment. Multivariate logistic regression analyses were used to identify the correlates of cognitive impairment. Results: Mean age of participants was 77.7 ± 5.8 years. The prevalence of cognitive impairment was 14.1%. Univariate logistic regression analyses showed that diabetic nephropathy, depression symptoms, falls, and frailty were associated with cognitive impairment. Multivariate logistic regression analyses showed that urinary incontinence and frailty were independently associated with cognitive impairment. Cardiovascular risk factors and diabetes-related variables did not show significant association to cognitive impairment. Conclusions: Geriatric syndromes, but not cardiovascular risk factors, were independently associated with cognitive impairment among diabetic elderlies. Intentional evaluation of these conditions may be important to improve management of the elderly patient with type 2 diabetes and cognitive impairment. (REV INVES CLIN. 2017;69:166-72)

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Memory and executive functions in persons with type 2 diabetes: a meta‐analysis

Cited by 110 publications

References 62 publications

Type 2 Diabetes and Cognitive Functions in Middle Age: A Meta-Analysis

Type 2 Diabetes and Cognitive Functions in Middle Age: A Meta-Analysis

Markers of cognitive impairment in patients with type 2 diabetes

Geriatric Syndromes and Not Cardiovascular Risk Factors are Associated with Cognitive Impairment among Mexican Community-Dwelling Elderly with Type 2 Diabetes

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