Memory complaints moderate the concordance between self-report and electronically monitored adherence in adults with type 2 diabetes

Shapira, Amit; Kane, Naomi S.; Tanenbaum, Molly L.; Hoogendoorn, Claire J.; Gonzalez, Jeffrey S.

doi:10.1016/j.jdiacomp.2022.108205

Cited by 1 publication

(2 citation statements)

References 29 publications

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“…Subjective methods are based on patient self‐reporting, which is susceptible to biases since patients can underreport their non‐adherence 3 . In addition, subjective methods depend on a participant's memory, which is susceptible to underreporting 6 . Objective methods include counting pills, electronic records, secondary data surveys, and medication events monitoring systems (MEMSs) 3 .…”

Section: Introductionmentioning

confidence: 99%

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Exploration of smart adherence‐monitoring methods in vitamin D‐deficient patients: A pilot feasibility clinical study

Huh

Lee²,

Lee

et al. 2023

Clinical Translational Sci

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Treatment adherence is an underestimated determinant of treatment success. Poor treatment adherence can also affect the efficacy of clinical trials. A combination of multiple adherence‐monitoring methods is required to ensure robustness. We investigated whether multiple adherence‐monitoring methods, including a novel smartwatch‐based monitoring method, would yield reliable and concordant results. In this open, randomized, decentralized clinical trial, vitamin D‐deficient individuals were randomized to an App − only group (an electronic medication diary) or an App + Watch group (i.e., App and smartwatch‐based monitoring) groups after a week run‐in period. The participants received vitamin D supplements (1000 IU) for 12 weeks (two consecutive periods of 6 weeks) with two pill counts (at the sixth week) and biweekly blood samplings for serum 25(OH) vitamin D concentration. Adherence was assessed and compared between the methods. Sixteen participants were enrolled, of which 13 completed the study. Serum 25(OH) vitamin D levels comparably increased in both groups until the first 7 weeks but trended higher in the App + Watch group in the second period. The number of doses recorded by the pill count and App did not differ significantly between the run‐in and Period 1 (p = 0.5534) but became significantly discrepant in Period 2 (p = 0.0225). In contrast, the concordance for smartwatch‐based monitoring was consistent in either period (p = 0.5898 and p = 0.5839, respectively). We explored multiple adherence‐monitoring methods in this pilot feasibility clinical study. Smartwatch‐based adherence monitoring may be an objective and sensitive method for measuring treatment adherence.

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Section: Introductionmentioning

confidence: 99%

“… 3 In addition, subjective methods depend on a participant's memory, which is susceptible to underreporting. 6 Objective methods include counting pills, electronic records, secondary data surveys, and medication events monitoring systems (MEMSs). 3 A MEMS is one of the most reliable adherence‐monitoring methods.…”

Section: Introductionmentioning

confidence: 99%