Memory consolidation and reconsolidation of an inhibitory avoidance response in mice: effects of i.c.v. injections of hemicholinium-3

Boccia, Mariano Martín; Acosta, Gabriela Beatriz; Blake, Mariano Guillermo; Baratti, Carlos M.

doi:10.1016/j.neuroscience.2004.01.001

Cited by 76 publications

(80 citation statements)

References 33 publications

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“…After the completion of the retention test at each of the training-test intervals studied, the HACU in the hippocampus of the HC-3-treated mice was not significantly different from that of the control group. This apparent dissociation between neurochemistry and behavior suggests that the effects of HC-3 are probably not directly exerted on memory retrieval, and indicates that HACU inhibition took place at early stages of memory consolidation (10). These results agree with experimental and clinical evidence suggesting that brain Ach plays an essential role in mnemonic phenomena (27,28).…”

Section: Pharmacological Manipulation Of Memory Consolidation and Recsupporting

confidence: 83%

“…Thus, for the first time, we suggested a participation of central cholinergic mechanisms in memory reconsolidation of an IAR in mice (10,29).…”

Section: Pharmacological Manipulation Of Memory Consolidation and Recmentioning

confidence: 55%

“…This effect was observed even 7 days after the learning trial. The dose of HC-3 used in these experiments reduces the HACU in the hippocampus by approximately 50% after 60 min of its icv administration (10). After the completion of the retention test at each of the training-test intervals studied, the HACU in the hippocampus of the HC-3-treated mice was not significantly different from that of the control group.…”

Section: Pharmacological Manipulation Of Memory Consolidation and Recmentioning

confidence: 77%

“…We shall consider in this article the effects of intracerebroventricular (icv ) infusions of hemicholinium (HC-3), a central inhibitor of acetylcholine (Ach) synthesis (7), of intraperitoneal administration of N ω -nitro-L-arginine methyl ester (L-NAME), a non-specific inhibitor of nitric oxide synthase (NOS; 8), on post-training (memory consolidation) and post-reactivation (memory reconsolidation), and Memory consolidation and reconsolidation www.bjournal.com.br of intrahippocampal injections of an inhibitor of the transcription factor (nuclear factor κB, NF-κB; 9) on retention performance of an inhibitory avoidance response in mice (10)(11)(12)(13). We also will briefly discuss both the posttraining and the post-retrieval effects of the exposure of mice to a new learning experience (14).…”

Section: Introductionmentioning

confidence: 99%

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Pharmacological effects and behavioral interventions on memory consolidation and reconsolidation

Baratti

Boccia

Blake

2009

Braz J Med Biol Res

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In this article, we will review some behavioral, pharmacological and neurochemical studies from our laboratory on mice, which might contribute to our understanding of the complex processes of memory consolidation and reconsolidation. We discuss the post-training (memory consolidation) and post-reactivation (memory reconsolidation) effects of icv infusions of hemicholinium, a central inhibitor of acetylcholine synthesis, of intraperitoneal administration of L-NAME, a non-specific inhibitor of nitric oxide synthase, of intrahippocampal injections of an inhibitor of the transcription factor NF-κB, and the exposure of mice to a new learning situation on retention performance of an inhibitory avoidance response. All treatments impair long-term memory consolidation and retrieval-induced memory processes different from extinction, probably in accordance with the "reconsolidation hypothesis".

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Section: Pharmacological Manipulation Of Memory Consolidation and Recsupporting

confidence: 83%

“…Thus, for the first time, we suggested a participation of central cholinergic mechanisms in memory reconsolidation of an IAR in mice (10,29).…”

Section: Pharmacological Manipulation Of Memory Consolidation and Recmentioning

confidence: 55%

Section: Pharmacological Manipulation Of Memory Consolidation and Recmentioning

confidence: 77%

Section: Introductionmentioning

confidence: 99%

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Pharmacological effects and behavioral interventions on memory consolidation and reconsolidation

Baratti

Boccia

Blake

2009

Braz J Med Biol Res

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“…If scopolamine is given after training, retrograde amnesia is also produced, suggesting that cholinergic system is necessary for memory consolidation (Berón de Astrada & Maldonado, 1999;Blake et al, 2011;Boccia et al, 2004;Roldán et al, 1997).…”

Section: Discussionmentioning

confidence: 99%

Choline reverses scopolamine-induced memory impairment by improving memory reconsolidation

Blake

Boccia

Krawczyk

et al. 2012

Neurobiology of Learning and Memory

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Please cite this article as: Blake, M.G., Boccia, M.M., Krawczyk, M.C., Delorenzi, A., Baratti, C.M., Choline reverses scopolamine-induced memory impairment by improving memory reconsolidation, Neurobiology of Learning and Memory (2012), doi: http://dx.doi. org/10.1016/j.nlm.2012.07.001 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. were not subjected to memory reactivation, suggesting that the performance effects are not due to non-specific effects of the drug. The effects of Ch also depended on the age of the reactivated memory. Altogether, our results suggest that Ch exerts its effects by modulating memory reconsolidation, and that the memory impairment induced by low doses of SCP is a memory expression failure and not a storage deficit. Therefore, reconsolidation, among other functions, might serve to change memory expression in later tests. Summarizing, our results open new avenues about the behavioral significance and the physiological functions of memory reconsolidation, providing new strategies for recovering memories from some types of amnesia. Research highlights-Pre-training administration of scopolamine leads to memory impairment.-Intra-hippocampal administration of choline modulates memory reconsolidation -Choline reverses scopolamine-induced amnesia by enhancing memory reconsolidation -Low doses of scopolamine cause memory expression deficit, but not storage impairment -Reconsolidation could modify the ability of a memory for being expressed later

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A synaptic reinforcement‐based model for transient amnesia following disruptions of memory consolidation and reconsolidation

et al. 2008

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The observation of memory recovery following post-training amnestic interventions has historically caused controversy over the meaning of this finding, leading some authors to question the paradigm of a consolidation period for memories. Similarly, recent demonstrations of transient amnesia caused by interventions following memory reactivation have been used to question the existence of a retrieval-driven reconsolidation process. The present work aims to approach the phenomenon of transient amnesia following disruptions of consolidation and reconsolidation, discussing how memory recovery might be explained within a framework of systems consolidation, persistent synaptic reinforcement, and multiple memory traces. With these concepts in mind, we propose that long-term consolidation processes can underlie recovery from amnesia, demonstrating the feasibility of such a hypothesis in a two-structure computational model of learning in which consolidation is dependent upon synaptic reentry reinforcement. On the basis of this, we suggest that prolonged consolidation can account for experimental findings of transient amnesia, in a way that explains differences between disruptions of consolidation and reconsolidation without the need to dwell into the discussion between storage- and retrieval-based explanations for memory impairment.

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Memory consolidation and reconsolidation of an inhibitory avoidance response in mice: effects of i.c.v. injections of hemicholinium-3

Cited by 76 publications

References 33 publications

Pharmacological effects and behavioral interventions on memory consolidation and reconsolidation

Pharmacological effects and behavioral interventions on memory consolidation and reconsolidation

Choline reverses scopolamine-induced memory impairment by improving memory reconsolidation

A synaptic reinforcement‐based model for transient amnesia following disruptions of memory consolidation and reconsolidation

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