Memory consolidation in sleep disorders

Cellini, Nicola

doi:10.1016/j.smrv.2016.09.003

Cited by 78 publications

(58 citation statements)

References 100 publications

(104 reference statements)

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“…However, the potential benefit depends on the paradigm used, the type of the cues used, and the timing of the stimulation. Moreover, at the translational level, the application of TMR to address real‐world issues, for example, to increase learning abilities in students, to compensate for the cognitive deficits observed in sleep or neurodegenerative disorders, to facilitate rehabilitation programs, or to aid clinicians in treating psychiatric disorders, has yet to be achieved. To sum up, the studies presented in the current review show promising but not systematic results for TMR, and further studies are needed to optimize this technique and facilitate its translation to real‐word applications.…”

Section: Resultsmentioning

confidence: 99%

Shaping memory consolidation via targeted memory reactivation during sleep

Cellini

Capuozzo

2018

Annals of the New York Academy of Sciences

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Recent studies have shown that the reactivation of specific memories during sleep can be modulated using external stimulation. Specifically, it has been reported that matching a sensory stimulus (e.g., odor or sound cue) with target information (e.g., pairs of words, pictures, and motor sequences) during wakefulness, and then presenting the cue alone during sleep, facilitates memory of the target information. Thus, presenting learned cues while asleep may reactivate related declarative, procedural, and emotional material, and facilitate the neurophysiological processes underpinning memory consolidation in humans. This paradigm, which has been named targeted memory reactivation, has been successfully used to improve visuospatial and verbal memories, strengthen motor skills, modify implicit social biases, and enhance fear extinction. However, these studies also show that results depend on the type of memory investigated, the task employed, the sensory cue used, and the specific sleep stage of stimulation. Here, we present a review of how memory consolidation may be shaped using noninvasive sensory stimulation during sleep.

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Section: Resultsmentioning

confidence: 99%

Shaping memory consolidation via targeted memory reactivation during sleep

Cellini

Capuozzo

2018

Annals of the New York Academy of Sciences

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“…Here we will briefly discuss insomnia and obstructive sleep apnea syndrome (OSA), the two most frequent sleep disorders that are especially associated with AD. Insomnia and OSA have been shown to affect sleep-related memory consolidation, by reducing sleep time, altering sleep architecture, and/or producing fragmented sleep [43].…”

Section: Sleep and Memory In Sleep Disordersmentioning

confidence: 99%

“…Insomnia is defined a difficulty initiating or maintaining sleep, or early morning awakening associated with an impairment during daytime [43]. The European prevalence varied between 5.7% to 19% [44] and its chronic form was related to a higher risk of cardiovascular diseases [45], depression [46], and cognitive impairment [47].…”

Section: Insomniamentioning

confidence: 99%

Is Sleep Disruption a Cause or Consequence of Alzheimer’s Disease? Reviewing Its Possible Role as a Biomarker

Lloret

Cervera‐Ferri

Nepomuceno

et al. 2020

IJMS

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In recent years, the idea that sleep is critical for cognitive processing has gained strength. Alzheimer's disease (AD) is the most common form of dementia worldwide and presents a high prevalence of sleep disturbances. However, it is difficult to establish causal relations, since a vicious circle emerges between different aspects of the disease. Nowadays, we know that sleep is crucial to consolidate memory and to remove the excess of beta-amyloid and hyperphosphorilated tau accumulated in AD patients' brains. In this review, we discuss how sleep disturbances often precede in years some pathological traits, as well as cognitive decline, in AD. We describe the relevance of sleep to memory consolidation, focusing on changes in sleep patterns in AD in contrast to normal aging. We also analyze whether sleep alterations could be useful biomarkers to predict the risk of developing AD and we compile some sleep-related proposed biomarkers. The relevance of the analysis of the sleep microstructure is highlighted to detect specific oscillatory patterns that could be useful as AD biomarkers.the risk of developing AD [9]. Similarly, Bubu and colleagues estimated in a meta-analysis that the risk of dementia in patients with sleep disorders was 1.68 times greater [10]. Moreover, in a recent multi-center study, both midlife and late-life terminal insomnia were associated with a higher risk of dementia [11].It is interesting to note that affected brain structures in people with disturbed sleep coincide with vulnerable areas in AD. Lower gray matter volume in hippocampus, precuneus, amygdala, and cingulate gyrus [12][13][14][15][16][17][18][19], and a higher degree of cortical atrophy have been described in cognitively-unimpaired insomnia patients [14,20]. A recent study performed in cognitively unimpaired adults aged between 45 and 75, found that insomnia patients presented decreases in grey matter volume in AD-related areas, that concur with other studies. Furthermore, they found greater volume in the left caudate in these subjects, which can also be seen in presymptomatic carriers of an AD genetic mutation [21]. Finally, a very recent study in middle-aged, cognitively unimpaired adults found lower grey matter volumes in the left angular gyrus, the bilateral superior frontal gyri, the thalami, and the right hippocampus in insomniac APOE-ε4 carriers (AD's main risk factor) when compared to non-carriers with or without insomnia [21].This temporal and anatomical relationship could suggest that sleep disturbances may influence or exacerbate AD pathology and that improving sleep may help slow down its progression [22,23]. Additionally, sleep alterations could be used to predict the risk of developing dementia and could also serve as early indicators of the disease. If sleep disorders constitute a risk factor to initiate or to accelerate the clinical course of AD, they could be used to develop disease biomarkers. Furthermore, a sleep biomarker with high sensitivity and specificity would be extremely useful, as electrophysiological re...

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“…It is important to note that a number of sleep disorders was shown to result in deficits in memory consolidation, and that these deficits are correlated with alterations of NREM sleep architecture (Cellini, 2017). Indeed, patients suffering from insomnia or obstructive sleep apnea exhibit fragmented sleep patterns and show either no improvement or worsening scores on wordpair association tasks following a night of sleep (Cellini, 2017;Maski et al, 2017). Narcolepsy is another disorder which alters the sleep architecture and it has been shown to impact the sleepdependent gain procedural memory consolidation (Mazzetti et al, 2012;Mazzetti et al, 2016;Cellini, 2017).…”

Section: Sleep and Memory Consolidationmentioning

confidence: 99%

“…Indeed, patients suffering from insomnia or obstructive sleep apnea exhibit fragmented sleep patterns and show either no improvement or worsening scores on wordpair association tasks following a night of sleep (Cellini, 2017;Maski et al, 2017). Narcolepsy is another disorder which alters the sleep architecture and it has been shown to impact the sleepdependent gain procedural memory consolidation (Mazzetti et al, 2012;Mazzetti et al, 2016;Cellini, 2017). Similar to our previous work (Wei et al, 2016;Wei et al, 2018), here we found that slow-wave sleep was beneficial for the consolidation of multiple memory sequences in the thalamocortical network model.…”

Section: Sleep and Memory Consolidationmentioning

confidence: 99%

Can sleep protect memories from catastrophic forgetting?

González

Sokolov

Bazhenov

2019

Preprint

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Previously encoded memories can be damaged by encoding of new memories, especially when they are relevant to the new data and hence can be disrupted by new training -a phenomenon called "catastrophic forgetting". Human and animal brains are capable of continual learning, allowing them to learn from past experience and to integrate newly acquired information with previously stored memories. A range of empirical data suggest important role of sleep in consolidation of recent memories and protection of the past knowledge from catastrophic forgetting. To explore potential mechanisms of how sleep can enable continual learning in neuronal networks, we developed a biophysically-realistic thalamocortical network model where we could train multiple memories with different degree of interference. We found that in a wakelike state of the model, training of a "new" memory that overlaps with previously stored "old" memory results in degradation of the old memory. Simulating NREM sleep state immediately after new learning led to replay of both old and new memories -this protected old memory from

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Memory consolidation in sleep disorders

Cited by 78 publications

References 100 publications

Shaping memory consolidation via targeted memory reactivation during sleep

Shaping memory consolidation via targeted memory reactivation during sleep

Is Sleep Disruption a Cause or Consequence of Alzheimer’s Disease? Reviewing Its Possible Role as a Biomarker

Can sleep protect memories from catastrophic forgetting?

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