Memory Correlates of Alzheimer’s Disease Cerebrospinal Fluid Markers: A Longitudinal Cohort Study

Reijs, Babette L.R.; Ramakers, Inez H.G.B.; Köhler, Sebastian; Teunissen, Charlotte E.; Koel-Simmelink, Marleen; Nathan, Pradeep J.; Tsolaki, Magda; Wahlund, Lars Olof; Waldemar, Gunhild; Hausner, Lucrezia; Vandenberghe, Rik; Johannsen, Peter; Blackwell, Andrew D.; Vanderstichele, Hugo; Verhey, Frans R.J.; Visser, Pieter Jelle

doi:10.3233/jad-160766

Cited by 26 publications

(21 citation statements)

References 46 publications

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“…Considering its cost-effectiveness and sensitivity, this global cognitive functioning measure serves as one of the most effective instruments for monitoring patients with AD over time [ 1, 9, 10 ]. Our results also support previous reports that changes in the WMS-R delayed logical memory [ 31 ], visuospatial construction [ 39 ] and semantic fluency [ 40 ] scores are suggestive of disease progression in mild AD.…”

Section: Discussionsupporting

confidence: 92%

Identification of a Cascade of Changes in Activities of Daily Living Preceding Short-Term Clinical Deterioration in Mild Alzheimer’s Disease Dementia via Lead-Lag Analysis

Fuentes

Klostermann

Kleineidam

et al. 2020

JAD

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Background: Cognitive functions and activities of daily living (ADL) become increasingly impaired with progressing Alzheimer's disease. However, the temporal dynamics of this decline are inconsistent. Objective: To gain insight into the classical temporal cascade of specific cognitive and ADL changes, which may aid in improving detection of an impending clinical deterioration in patients, and to select ADL items and tests most sensitive to change in a specific disease stage.

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Section: Discussionsupporting

confidence: 92%

Identification of a Cascade of Changes in Activities of Daily Living Preceding Short-Term Clinical Deterioration in Mild Alzheimer’s Disease Dementia via Lead-Lag Analysis

Fuentes

Klostermann

Kleineidam

et al. 2020

JAD

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“…In the current analysis, cognitive/memory performance correlated with CSF tau levels (t-tau and p-tau181P) in the early stages of the AD continuum (Rami et al, 2011;Reijs et al, 2017).…”

Section: Discussionmentioning

confidence: 67%

Relevance of the interplay between amyloid and tau for cognitive impairment in early Alzheimer's disease

Timmers

Tesseur

Bogert

et al. 2019

Neurobiology of Aging

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Amyloid β (Aβ) and tau are key hallmark features of Alzheimer's disease (AD) neuropathology. The interplay of Aβ and tau for cognitive impairment in early AD was examined with crosssectional analysis, measured by cerebrospinal fluid (CSF) biomarkers (Aβ1-42, total tau [t-tau] and phosphorylated tau [p-tau181P]), and on cognitive performance by the repeatable battery for assessment of neuropsychological status (RBANS). Participants (n=246) included cognitively normal (Aβ−), mild cognitively impaired (Aβ−), preclinical AD (Aβ+), and prodromal AD (Aβ+). Overall, cognitive impairment (RBANS Total Scale score) had a moderate negative correlation to t-tau (n=246; r=−0.434; p<0.001) and p-tau181P (r=−0.389; p<0.001). When classified by Aβ status, this correlation to t-tau was applicable only in Aβ+ participants (n=139; r=−0.451, p<0.001) but not Aβ− participants (n=107; r=0.137, p=0.16), with identical findings for p-tau. Both tau (p<0.0001) and interaction of Aβ1-42 with tau (p=0.006) affected RBANS, but not Aβ1-42 alone. Cognitive/memory performance correlated well with CSF tau levels across early stages of AD, although the correlation is Aβ dependent.

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“…PAL performance is sensitive to disease progression in AD, including amnestic MCI [17], [18], [19], [20], [42], [43]. Impairment or deterioration in PAL performance has been linked to biomarkers sensitive to disease progression in AD.…”

Section: Discussionmentioning

confidence: 99%

“…These include: minimization of floor and ceiling effects through flexibility of test difficulty levels, standardization of assessment, accuracy of response recordings, automated scoring, and reduced cost of administration [7] , [15] . Here we present results from cognitive tests of episodic memory, executive functioning, and processing speed, which have previously shown sensitivity to mild cognitive impairment (MCI), dementia, and cognitive aging [16] , [17] , [18] , [19] , [20] , [21] , [22] .…”

Section: Introductionmentioning

confidence: 99%

Normative data from linear and nonlinear quantile regression in CANTAB: Cognition in mid‐to‐late life in an epidemiological sample

Abbott

Skirrow

Jokisch

et al. 2018

Alz & Dem Diag Ass & Dis Mo

Self Cite

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Introduction Normative cognitive data can help to distinguish pathological decline from normal aging. This study presents normative data from the Cambridge Neuropsychological Test Automated Battery, using linear regression and nonlinear quantile regression approaches. Methods Heinz Nixdorf Recall study participants completed Cambridge Neuropsychological Test Automated Battery tests: paired-associate learning, spatial working memory, and reaction time. Data were available for 1349-1529 healthy adults aged 57-84 years. Linear and nonlinear quantile regression analyses examined age-related changes, adjusting for sex and education. Quantile regression differentiated seven performance bands (percentiles: 97.7, 93.3, 84.1, 50, 15.9, 6.7, and 2.3). Results Normative data show age-related cognitive decline across all tests, but with quantile regression revealing heterogeneous trajectories of cognitive aging, particularly for the test of episodic memory function (paired-associate learning). Discussion This study presents normative data from Cambridge Neuropsychological Test Automated Battery in mid-to-late life. Quantile regression can model heterogeneity in age-related cognitive trajectories as seen in the paired-associate learning episodic memory measure.

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Memory Correlates of Alzheimer’s Disease Cerebrospinal Fluid Markers: A Longitudinal Cohort Study

Abstract: Tests assessing episodic verbal and visuospatial memory are most useful for detection of AD pathology. Tests for episodic verbal memory and semantic memory are most useful for tracking memory decline.

Cited by 26 publications

References 46 publications

Identification of a Cascade of Changes in Activities of Daily Living Preceding Short-Term Clinical Deterioration in Mild Alzheimer’s Disease Dementia via Lead-Lag Analysis

Identification of a Cascade of Changes in Activities of Daily Living Preceding Short-Term Clinical Deterioration in Mild Alzheimer’s Disease Dementia via Lead-Lag Analysis

Relevance of the interplay between amyloid and tau for cognitive impairment in early Alzheimer's disease

Normative data from linear and nonlinear quantile regression in CANTAB: Cognition in mid‐to‐late life in an epidemiological sample

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