Memory deficits in workers suffering from hard metal disease

Jordan, Catherine; Whitman, R. Douglas; Harbut, Michael; Tanner, Barry A.

doi:10.1016/0378-4274(90)90190-w

Cited by 29 publications

(18 citation statements)

References 3 publications

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“…While there are no epidemiology studies indicating an increased incidence of any neurological disturbances in Co-exposed cohorts, there have been case reports involving high exposures to Co in occupational settings or as a result of therapy (e.g., for anemia or pancytopenia), wherein the individuals developed polyneuropathy or optic atrophy (Gardner, 1953;Schleisner, 1956;Schirrmacher, 1967;Licht et al, 1972;Jordan et al, 1990;Meecham and Humphrey, 1991). Many of these cases involved anephric patients on dialysis, and, as mentioned earlier it is known that renal failure can result in reduced Co clearance from the bloodstream.…”

Section: Neurotoxicitymentioning

confidence: 97%

Derivation of a chronic oral reference dose for cobalt

Finley¹,

Monnot²,

Paustenbach³

et al. 2012

Regulatory Toxicology and Pharmacology

113

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Section: Neurotoxicitymentioning

confidence: 97%

Derivation of a chronic oral reference dose for cobalt

Finley¹,

Monnot²,

Paustenbach³

et al. 2012

Regulatory Toxicology and Pharmacology

113

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“…Tungsten compounds internalized as embedded shrapnel frequently cannot be removed from brain tissue because of their location and/or small size, which may cause chronic health effects. Neurological and chronic respiratory problems in metallurgy workers, miners, and in a French soldier exposed to tungsten have been reported Jordan et al, 1990;Marquet et al, 1996). Tungsten exposure via drinking water has been associated with onset of acute lymphocytic leukemia clusters (Rubin et al, 2007;Sheppard et al, 2007;Steinmaus et al, 2004).…”

mentioning

confidence: 99%

In vitro profiling of epigenetic modifications underlying heavy metal toxicity of tungsten-alloy and its components

Verma¹,

Xu²,

Jaiswal³

et al. 2011

Toxicology and Applied Pharmacology

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In vitro profiling of epigenetic modifications underlying heavy metal toxicity of tungsten-alloy and its components" (2011 Tungsten-alloy has carcinogenic potential as demonstrated by cancer development in rats with intramuscular implanted tungsten-alloy pellets. This suggests a potential involvement of epigenetic events previously implicated as environmental triggers of cancer. Here, we tested metal induced cytotoxicity and epigenetic modifications including H3 acetylation, H3-Ser10 phosphorylation and H3-K4 trimethylation. We exposed human embryonic kidney (HEK293), human neuroepithelioma (SKNMC), and mouse myoblast (C2C12) cultures for 1-day and hippocampal primary neuronal cultures for 1-week to 50-200 μg/ml of tungsten-alloy (91% tungsten/6% nickel/3% cobalt), tungsten, nickel, and cobalt. We also examined the potential role of intracellular calcium in metal mediated histone modifications by addition of calcium channel blockers/chelators to the metal solutions. Tungsten and its alloy showed cytotoxicity at concentrations N 50 μg/ml, while we found significant toxicity with cobalt and nickel for most tested concentrations. Diverse cell-specific toxic effects were observed, with C2C12 being relatively resistant to tungsten-alloy mediated toxic impact. Tungsten-alloy, but not tungsten, caused almost complete dephosphorylation of H3-Ser10 in C2C12 and hippocampal primary neuronal cultures with H3-hypoacetylation in C2C12. Dramatic H3-Ser10 dephosphorylation was found in all cobalt treated cultures with a decrease in H3 pan-acetylation in C2C12, SKNMC and HEK293. Trimethylation of H3-K4 was not affected. Both tungsten-alloy and cobalt mediated H3-Ser10 dephosphorylation were reversed with BAPTA-AM, highlighting the role of intracellular calcium, confirmed with 2-photon calcium imaging. In summary, our results for the first time reveal epigenetic modifications triggered by tungsten-alloy exposure in C2C12 and hippocampal primary neuronal cultures suggesting the underlying synergistic effects of tungsten, nickel and cobalt mediated by changes in intracellular calcium homeostasis and buffering.Published by Elsevier Inc.

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“…Thus, if chronic tungsten exposure does have an anticholinesterase effect, causing an accumulation of ACh in the CNS, effects of the type observed by Jordan et al(1990) on attention and memory would be consistent with the responses seen in humans exposed to OP anticholinesterase compounds.…”

Section: F-12mentioning

confidence: 64%

“…Studies of occupationally exposed workers whose exposure included cobalt, a known toxin from hardmetal dusts, found persons with signs and symptoms such as loss of appetite, nausea, and an impaired sense of smell; in one study, some also reported headaches and dizziness (Kaplun and Mezentseva 1959;Vengerskaya and Salikhodzhaev 1962). A small study was done recently on hard-metal workers having pulmonary problems and reporting memory deficits (Jordan et al 1990). Testing demonstrated significant deficits in verbal memory and attention.…”

Section: Quality and Quantity Of Datamentioning

confidence: 99%

Environmental acceptability of high-performance alternatives for depleted uranium penetrators

Kerley¹,

Easterly²,

Eckerman³

1996

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MASTThis report was prepared as an account of work sponsored by an agency of the United States Government, Neither the United States Government nor any agency thereof, nor any of their employees, makes any warranty, express or implied. or assumes any legal liability or responsibility for the accuracy, completeness, or usefulness of any information, apparatus, product. o r process disclosed. or represents that its use would not infringe privately owned rights. Reference 8-58-5 8-6A-iii c.5Diagram of the biokinetic model for systemic tungsten used in G-7Stages in carcinogenesis as described by Kouri, Henry, G-41Graphical comparisons of potencies completed in LIST OF TABLES 4-10Comparison 5-6Tungsten and uranium content of body organs (g) assuming chronic intake G-31Common scales of toxicological potency for 67 compounds based on RPs to five reference compounds from Table G G-36Fitted values for a log-normal frequency distribution function comparing potency-adjusted 'IDs and maximum doses tested G-43Toxicological test data for sodium chromate (VI) [RTECS #GB2955OOO] . . . . . . . . G-44Summary of the potency of four tungsten compounds and sodium chromate relative to B(a)P, cyclophosphomide, nicotine, aflatoxin B,, and cisplatin all converted to a common scale indexed by unit potency for B(a)P; cyclophosphomide, nicotine, aflatoxin, and cisplatin were standardized according to potencies listed at the bottom of the G-46xii EXECUTIVE SUMMARYThis document summarizes the results from the first phase (Phase I) of a proposed three-year effort to evaluate the environmental acceptability of tungsten (W) as an alternative to depleted uranium (DU) in kinetic energy penetrators (KEPs). The objective of this study was to evaluate the environmental impacts of tungsten in a military context in response to military and congressional concerns regarding exposures to DU. The primary purposes of this Phase I study were to review the literature for existing data; to formulate a test methodology that will provide a useful life cycle assessment of the environmental impacts of tungsten; and to identify where the data gaps exist. In this initial effort, the environmental pathways by which tungsten chemical species (from penetrator impact fragments and aerosols), deposited on the soil, might find their way into humans were identified. In addition, a new computer-based modeling tool was developed which enables predictions of the ways tungsten is retained and distributed in the body. The toxic effects which might be produced were addressed. This approach can be applicable to other materials and, in fact, provides a useful tool for comparing the relative environmental impacts expected from numerous, alternative materials.An extensive review of the literature reveals that little quantitative information and data are available to permit reliable simulations of tungsten toxicity in humans. In particular, the relative corrosion kinetics of each metal, the relative solubilities in corrosive media, and the relative rate of diffus...

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Memory deficits in workers suffering from hard metal disease

Cited by 29 publications

References 3 publications

Derivation of a chronic oral reference dose for cobalt

Derivation of a chronic oral reference dose for cobalt

In vitro profiling of epigenetic modifications underlying heavy metal toxicity of tungsten-alloy and its components

Environmental acceptability of high-performance alternatives for depleted uranium penetrators

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