Memory dysfunction in multiple sclerosis: Its relation to working memory, semantic encoding, and implicit learning.

Rao, Stephen M.; Grafman, Jordan; DiGiulio, Diane; Mittenberg, Wiley; Bernardin, Linda; Leo, Gary J.; Luchetta, Tracy; Unverzagt, Frederick W.

doi:10.1037/0894-4105.7.3.364

Cited by 182 publications

(146 citation statements)

References 42 publications

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“…Two early studies (Heaton 1985;Rao et al 1991a) revealed that as a group, patients with MS are most often impaired on neuropsychological tests that emphasize processing speed, working memory, new learning, and episodic memory. The finding of impaired cognitive performance in MS has been replicated many times (Beatty et al 1989;Fischer 1988;Rao et al 1993). Other cognitive impairments have been described, involving such domains as spatial processing (Vleugels et al 2000), verbal fluency (Beatty 2002), and higher executive function (Arnett et al 1997;Beatty et al 1995;Beatty and Monson 1996;Foong et al 1997).…”

Section: Comparison With Msmentioning

confidence: 83%

“…Roughly half of all MS patients are cognitively impaired (Beatty et al 1989;Fischer 1988;Rao et al 1993Rao et al , 1991a, although the incidence is somewhat higher in clinical samples (Benedict et al 2006c). Two early studies (Heaton 1985;Rao et al 1991a) revealed that as a group, patients with MS are most often impaired on neuropsychological tests that emphasize processing speed, working memory, new learning, and episodic memory.…”

Section: Comparison With Msmentioning

confidence: 99%

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Neuropsychological Impairment in Systemic Lupus Erythematosus: A Comparison with Multiple Sclerosis

et al. 2008

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In this manuscript, we review literature describing the neuropsychological and brain imaging characteristics of systemic lupus erythematosus (SLE) patients. The findings are compared and contrasted with multiple sclerosis (MS) studies, revealing similarities and differences of interest to clinicians and researchers. While cognitive impairment is somewhat less common in SLE than MS, the diseases share a similar cognitive profile with deficits most prominent on tests emphasizing the speed of information processing, working memory, and visual/spatial learning, and memory. In early or more mildly affected patients, diffuse white matter damage, which may not be apparent on conventional brain imaging, plays a major role in clinical presentation and cognitive testing. The causes of white matter damage are very different, however, and in later stages of the disease MS and SLE appear to give rise to different forms of cerebral pathology. MS may be characterized by increasing brain atrophy affecting especially the cortical and deep gray matter, at least after conversion to secondary progressive course. There is less evidence for neurodegenerative changes in SLE, but patients are increasingly at risk for cerebrovascular disease. We conclude by offering some suggestions for future clinical and imaging research. KeywordsSystemic lupus erythematosus; Multiple sclerosis; Cognition; Memory; Processing speed; MRI; Effect size Systemic lupus erythematosus (SLE) is a relapsing-remitting autoimmune disease with wide ranging organ involvement and clinical symptoms varying from mild and transient symptoms to death. Cognitive impairment is reported in SLE, even among those patients without documented or overt signs of central nervous system (CNS) involvement. Presumably, cognitive disorder is the result of underlying brain disease although the precise mechanisms remain to be elucidated. The prevalence and degree of cognitive impairment is also uncertain.In this article we will endeavor to evaluate the evidence for neuropsychological impairment in SLE, and to compare the findings with that of MS, another immunological disorder whose symptoms wax and wane and which affects women more than men. Unlike SLE, MS is a disease that always impacts the CNS, and the causes of cognitive disorder in MS are better understood.

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Section: Comparison With Msmentioning

confidence: 83%

Section: Comparison With Msmentioning

confidence: 99%

Neuropsychological Impairment in Systemic Lupus Erythematosus: A Comparison with Multiple Sclerosis

et al. 2008

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“…Approximately two thirds of patients experience cognitive problems (Rao et al, 1993;Amato, Zipoli, & Portaccio, 2006). These include deficits in memory, attention, and executive functions (Calabrese, 2006;Chiaravalotti & DeLuca, 2008), which cause difficulties in engaging in rehabilitation, maintaining employment, and participating in social activities.…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of cognitive rehabilitation for people with multiple sclerosis: a meta-synthesis of patient perspectives

Klein

Drummond

Mhizha-Murira

et al. 2017

Neuropsychological Rehabilitation

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While previous randomised controlled trials and meta-analyses offer only limited evidence for the effectiveness of cognitive rehabilitation, qualitative studies examining patient perspectives report more positive outcomes. This meta-synthesis of qualitative studies examined patient perspectives of cognitive rehabilitation for memory, attention, and executive function problems in people with multiple sclerosis. Using set eligibility criteria, we screened electronic databases, reference lists, and academic networks for

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“…Memory impairment is one of the most common neuropsychological deficits associated with MS, affecting 40%-65% (Rao et al, 1993). Memory impairments can affect all aspects of a persons' life:…”

Section: Introductionmentioning

confidence: 99%

Group-based memory rehabilitation for people with multiple sclerosis: Subgroup analysis of the ReMiND trial

Martin

Lincoln

Nair

2014

International Journal of Therapy and Rehabilitation

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Background/Aim Memory problems are frequently reported in people with multiple sclerosis (MS). These can be debilitating and affect individuals and their families. This subgroup analysis focused on the effectiveness of memory rehabilitation in patients with MS. Methods Data were extracted from a single-blind randomised controlled trial, the ReMiND trial, which also included participants with traumatic brain injury and stroke. Participants were randomly allocated to compensation or restitution treatment programmes, or a self-help control. The programmes were manual-based and comprised two individual sessions and ten group sessions. Outcome measures included assessments of memory, mood and activities of daily living. A total of 39 patients with MS participated in this study (ten males (26%), 29 females (74%); mean±SD age: 48.3±10.8 years). Results Comparison of groups showed no significant effect of treatment on memory, but there were significant differences between compensation and restitution on self-report symptoms of emotional distress at both five- (p=0.04) and seven-month (p=0.05) follow-up sessions. The compensation group showed less distress than the restitution group. Conclusions Individuals with MS who received compensation memory rehabilitation reported significantly less emotional distress than those who received restitution. Further research is needed to explore why self-reported memory problems did not differ between groups.

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Memory dysfunction in multiple sclerosis: Its relation to working memory, semantic encoding, and implicit learning.

Cited by 182 publications

References 42 publications

Neuropsychological Impairment in Systemic Lupus Erythematosus: A Comparison with Multiple Sclerosis

Neuropsychological Impairment in Systemic Lupus Erythematosus: A Comparison with Multiple Sclerosis

Effectiveness of cognitive rehabilitation for people with multiple sclerosis: a meta-synthesis of patient perspectives

Group-based memory rehabilitation for people with multiple sclerosis: Subgroup analysis of the ReMiND trial

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