Memory Effects Of Aronia Melanocarpa Fruit Juice In A Passive Avoidance Test In Rats

Abstract

To study the effect of Aronia melanocarpa fruit juice on memory in male Wistar rats. MATERIALS AND METHODS: The juice was administered orally for 7, 14, 21 and 30 days at doses of 2.5 ml/kg, 5 ml/kg and 10 ml/ kg. Memory was assessed in the one-way passive avoidance task (step through) which consisted of one training session and two retention tests (3 hours and 24 hours after training). The variables measured were the latency time to step into the dark compartment of the apparatus and the learning criterion (remaining in the illuminated compartment for at least 180 sec). RESULTS: Oral administration of Aronia melanocarpa fruit juice for 7 and 14 days resulted in a dose-dependent tendency to increase the latency time and the learning criterion compared to saline-treated controls but the effect failed to reach statistical signifi cance. After 21 days of treatment, the juice dose-dependently prolonged the latency time at the retention tests, the effect being signifi cant at doses of 5 ml/kg and 10 ml/kg. Applied for 30 days, the juice in all the tested doses increased signifi cantly the latency time at the retention tests and the dose of 10 ml/kg signifi cantly increased the percentage of rats reaching the learning criterion. CONCLUSION: These fi ndings suggest that Aronia melanocarpa fruit juice could improve memory in rats. The effect is probably due to the polyphenolic ingredients of the juice which have been shown to be involved in learning and memory processes.

Exploring the Effect of <b><i>Phyllanthus emblica</i></b> L. on Cognitive Performance, Brain Antioxidant Markers and Acetylcholinesterase Activity in Rats: Promising Natural Gift for the Mitigation of Alzheimer's Disease

“…Percentage of MR was also determined that indicate strong linkage with longterm memory. Valcheva-Kuzmanova et al [63] assessed the effect of Aronia melanocarpa fruit juice on memory in rats by the PA task and also reported similar findings. The RA test was used to examine WR and CR.…”

Analyzing Nootropic Effect of &lt;i&gt;Phyllanthus reticulatus&lt;/i&gt; Poir. on Cognitive Functions, Brain Antioxidant Enzymes and Acetylcholinesterase Activity against Aluminium-Induced Alzheimer’s Model in Rats: Applicable for Controlling the Risk Factors of Alzheimer’s Disease

“…The mean STL of rats treated with the EEPR were ominously higher than those of the other groups. In the study of effect of Aronia melanocarpa fruits juice on memory in rats, Valcheva-Kuzmanova et al, also reported analogous findings [71]. The RA test is used to assess learning and memory based on alteration of The rats brain biochemical parameters were expressed as mean ± SEM values (n = 6/group).…”

Chokeberries (Aronia melanocarpa) and Their Products as a Possible Means for the Prevention and Treatment of Noncommunicable Diseases and Unfavorable Health Effects Due to Exposure to Xenobiotics

“…Until now, the protective effects of A. melanocarpa berries and products made from them have been described in regard to heavy metals, such as Cd (Brzóska and others , ,b, ,b; Kowalczyk ; Roszczenko and others ) and Pb (Kowalczyk and others , ), ethanol (Niedworok and others ; Matsumoto and others ; Valcheva‐Kuzmanova and others , ), carbon tetrachloride (CCl 4 ; Valcheva‐Kuzmanova and others ), N‐nitrosocompounds (Atanasova‐Goranova and others ; Kujawska and others ), PAH (benzo‐[a]‐pyrene and 7,12‐dimethylbenz[a]anthracene; Gąsiorowski and others ; Szaefer and others ), sulphide‐2‐chloroethyl‐3‐chloropropyl (Kowalczyk and others ), 2‐amino fluorine (Gąsiorowski and others ), sulfur mustard (Kowalczyk and others ), and some medicines (Niedworok and others ; Valcheva‐Kuzmanova and others , , ; Dietrich‐Muszalska and others ; Figure ). Moreover, A. melanocarpa extract has been reported to protect from the harmfulness of tobacco smoke (Balansky and others ).…”

“…Chokeberries should not be confused with chokecherries, which are a different fruit and belong to the Genus Prunus . The results of some studies conducted in animal models indicate that chokeberries seem to be a possible means to counteract the unfavorable health effects of exposure to some xenobiotics (Niedworok and others , ; Kowalczyk and others ,b; Matsumoto and others ; Valcheva‐Kuzmanova and others , ,b; Szaefer and others ; Balansky and others ; Roszczenko and others ; Dietrich‐Muszalska and others ; Navaneethan and Rasool ; Brzóska and others ,b, ,b; Hao and others ). This issue needs special attention because humans in their lifetime are exposed to more and more numerous chemical substances dangerous to their health and some of them contribute to the development of noncommunicable diseases: heart and circulatory diseases, cancers, diabetes, obesity and overweight, digestive system disorders, colds, some skin troubles as well as disorders of the reproductive system and nervous system (Draz and others ; Hsu and others ; Ferraro and others ; Kalariya and others ; Shargorodsky and others ; Bakulski and others ; Choi and others ; Chen and others ; Liu and others ; Moitra and others ; Tellez‐Plaza and others ; Åkesson and others ; Sommar and others ; Wallin and others ; Wu and others ).…”