Memory for Duration: Role of Hippocampus and Medial Prefrontal Cortex

Jackson, Pamela; Kesner, Raymond P.; Amann, Kelly

doi:10.1006/nlme.1998.3859

Cited by 62 publications

(26 citation statements)

References 29 publications

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“…Overall, our data released in our present study, prove singularly congruent with several studies showing that hippocampal lesions resulted in an initial retention deficit of an object-spatial location association (the equivalent of D1 in our study) and spared performance for a more recent one (the equivalent of D2 in the present study) (Jackson et al, 1998; Gilbert and Kesner, 2004). Our present data are also in agreement with studies showing that the dHPC and the mPFC play significant roles in memory for the serial order of spatial and non-spatial information (Fortin et al, 2002; Kesner et al, 2002; Hannesson et al, 2004; Lisman et al, 2005; Kesner and Hopkins, 2006).…”

Section: Discussionsupporting

confidence: 93%

Stress induced a shift from dorsal hippocampus to prefrontal cortex dependent memory retrieval: role of regional corticosterone

Dominguez

Faucher

Henkous

et al. 2014

Front. Behav. Neurosci.

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Most of the deleterious effects of stress on memory retrieval are due to a dysfunction of the hippocampo-prefrontal cortex interplay. The role of the stress-induced regional corticosterone increase in such dysfunction remains however unclear, since there is no published study as yet dedicated to measuring corticosterone concentrations simultaneously in both the prefrontal cortex (mPFC) and the hippocampus (dHPC) in relation with memory impairments. To that aim, we first showed in Experiment 1 that an acute stress (3 electric footschocks; 0.9 mA each) delivered before memory testing reversed the memory retrieval pattern (MRP) in a serial discrimination task in which mice learned two successive discriminations. More precisely, whereas non-stressed animals remembered accurately the first learned discrimination and not the second one, stressed mice remembered more accurately the second discrimination but not the first one. We demonstrated that local inactivation of dHPC or mPFC with the anesthetic lidocaine recruited the dHPC activity in non-stress conditions whereas the stress-induced MRP inversion recruited the mPFC activity. In a second experiment, we showed that acute stress induced a very similar time-course evolution of corticosterone rises within both the mPFC and dHPC. In a 3rd experiment, we found however that in situ injections of corticosterone either within the mPFC or the dHPC before memory testing favored the emergence of the mPFC-dependent MRP but blocked the emergence of the dHPC-dependent one. Overall, our study evidences that the simultaneous increase of corticosterone after stress in both areas induces a shift from dHPC (non-stress condition) to mPFC-dependent MRP and that corticosterone is critically involved in mediating the deleterious effects of stress on cognitive functions involving the mPFC-HPC interplay.

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Section: Discussionsupporting

confidence: 93%

Stress induced a shift from dorsal hippocampus to prefrontal cortex dependent memory retrieval: role of regional corticosterone

Dominguez

Faucher

Henkous

et al. 2014

Front. Behav. Neurosci.

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“…This interdependence is reinforced by evidence, albeit from spatial tasks, that crossed unilateral lesions of the AT nuclei and the hippocampal system can produce severe memory deficits and that AT lesions produce reduced neuronal activity in the limbic system, including the retrosplenial cortex and hippocampus (Warburton et al, 2001;Jenkins et al, 2002;Jenkins et al, 2004). It would be valuable to have similar crossed-lesion and neuronalactivation evidence from the context of memory for temporal order, as well as tasks that examine memory for the frequency of events and memory for duration, which have also been reported as sensitive to hippocampal lesions (Kesner, 1990;Jackson et al, 1998;Kesner, 1998). In conclusion, AT lesions produce substantial deficits when the memory requirement is demanding, in terms of either spatial or temporal context.…”

Section: Discussionmentioning

confidence: 99%

Beyond Spatial Memory: The Anterior Thalamus and Memory for the Temporal Order of a Sequence of Odor Cues

Wolff¹,

Gibb²,

Dalrymple‐Alford³

2006

J. Neurosci.

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Influential recent proposals state that the anterior thalamic (AT) nuclei constitute key components of an "extended hippocampal system." This idea is, however, based on lesion studies that used spatial memory tasks and there has been no evidence that AT lesions cause deficits in any hippocampal-dependent nonspatial tasks. The present study investigated the role of the AT nuclei in nonspatial memory for a sequence of events based on the temporal order of a list of odors, because this task has recently been shown to depend on the integrity of the hippocampal formation. After preoperative training, rats with excitotoxic lesions of the AT nuclei showed a severe and selective postoperative impairment when required to remember the order of pseudorandom sequences of six odors. The rats with AT lesions were able instead to learn two new tasks that required recognition memory and the identification of the prior occurrence of events independent of their order. These results strongly matched those described after hippocampal lesions and provide the first unequivocal evidence of a detrimental effect of an AT lesion on a nonspatial hippocampal-dependent memory task.

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“…Cortical areas of the medial wall not only contribute to motor functions, but are also activated in cognitive tasks (Picard and Strick 2001). Only few data exist on an explicit role in timing, and these do not imply a specific role (Jackson et al 1998). To some extent, the anterior cingulate activation as well as a part of the activations in basal ganglia (other than the timing-related right putamen region) are most likely effects of the motor component, i.e.…”

Section: Discussionmentioning

confidence: 99%

Processing of temporal information and the basal ganglia: new evidence from fMRI

et al. 2003

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Temporal information processing is a fundamental brain function, which might include central timekeeping mechanisms independent of sensory modality. Psychopharmacological and patient studies suggest a crucial role of the basal ganglia in time estimation. In this study, functional magnetic resonance imaging (fMRI) was applied in 15 healthy right-handed male subjects performing an auditory time estimation task (duration discrimination of tone pairs in the range of 1,000-1,400 ms) and frequency discriminations (tone pairs differing in pitch, around 1,000 Hz) as an active control task. Task difficulty was constantly modulated by an adaptive algorithm (weighted up-down method) reacting on individual performance. Time estimation (vs rest condition) elicited a distinct pattern of cerebral activity, including the right medial and both left and right dorsolateral prefrontal cortices (DLPFC), thalamus, basal ganglia (caudate nucleus and putamen), left anterior cingulate cortex, and superior temporal auditory areas. Most activations showed lateralisation to the right hemisphere and were similar in the frequency discrimination task. Comparing time and frequency tasks, we isolated activation in the right putamen restricted to time estimation only. This result supports the notion of central processing of temporal information associated with basal ganglia activity. Temporal information processing in the brain might thus be a distributed process of interaction between modality-dependent sensory cortical function, the putamen (with a timing-specific function), and additional prefrontal cortical systems related to attention and memory. Further investigations are needed to delineate the differential contributions of the striatum and other areas to timing.

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Memory for Duration: Role of Hippocampus and Medial Prefrontal Cortex

Cited by 62 publications

References 29 publications

Stress induced a shift from dorsal hippocampus to prefrontal cortex dependent memory retrieval: role of regional corticosterone

Stress induced a shift from dorsal hippocampus to prefrontal cortex dependent memory retrieval: role of regional corticosterone

Beyond Spatial Memory: The Anterior Thalamus and Memory for the Temporal Order of a Sequence of Odor Cues

Processing of temporal information and the basal ganglia: new evidence from fMRI

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