Memory for spatial location in ‘de novo’ parkinsonian patients

Spatial deficits in a mouse model of Parkinson disease

“…*p< 0.05 SO vs NSO within the same group cognitive deficit induced by striatal DA depletion is selective for visuo-spatial information processing rather than caused by a generalized memory deficit or a motivational impairment. The similarity of the results of the present study with those obtained in patients at the early stages of PD demonstrates that some of cognitive deficits in PD might not be a consequence of frontal dysfunction per se, but rather due to impaired DA activity in the striatum (Owen et al 1992(Owen et al , 1998Postle et al 1997;Pillon et al 1997). The high face validity of the spatial task used prompts the use of this model to better assess the cognitive deficits in PD and to discover new pharmacological treatments.…”

“…Indeed, the cognitive abnormalities observed in PD patients do not match closely those observed in frontal lobe patients (Owen et al 1993). Furthermore, they have been reported even at the early stage of the disease when the degeneration of DA neurons is restricted to the striatal projections (Owen et al 1997;Pillon et al 1997). Preclinical studies in rodents confirm the involvement of the nigrostriatal DA system in mediating learning and memory processes.…”

Metabotropic Glutamate Receptors 5 Blockade Reverses Spatial Memory Deficits in a Mouse Model of Parkinson's Disease

“…It is widely recognized that motor symptoms are accompanied by cognitive deficits in Parkinsonian patients even at the early stages of the disease, when dopamine (DA) depletion is restricted to the striatal complex (Owen et al, 1997;Pillon et al, 1997Pillon et al, , 1998. On the basis of recent evidence, visuo-spatial memory impairments seem to be the most constantly reported cognitive deficit in Parkinson's disease (PD) patients (Berger et al, 2004;Cools et al, 2002Cools et al, , 2007Giraudo et al, 1997;Lewis et al, 2003;Owen et al, 1998;Pillon et al, 1997Pillon et al, , 1998.…”

“…On the basis of recent evidence, visuo-spatial memory impairments seem to be the most constantly reported cognitive deficit in Parkinson's disease (PD) patients (Berger et al, 2004;Cools et al, 2002Cools et al, , 2007Giraudo et al, 1997;Lewis et al, 2003;Owen et al, 1998;Pillon et al, 1997Pillon et al, , 1998. Consistently, extensive DA lesions, obtained through either medial forebrain bundle or dorsal striatum 6-hydroxydopamine (6-OHDA) administrations, have been found to impair memory in the spatial version of the Morris water maze in rats (Miyoshi et al, 2002;Mura and Feldon, 2003;Whishaw and Dunnett, 1985).…”

Brain Event - Related Oscillations in Parkinsonian Patients During Discrimination Task Conditions

“…Alterations of the basal ganglia with proven neuronal degenerative disorders of dopaminergic neurons and a reduction in activity in frontostriatal neural circuitry have been suggested to play a role in the executive dysfunction of PD (Taylor et al, 1990;Innis et al, 1993;Lewis et al, 2003;Owen, 2004;Leblois et al, 2006;Anik et al, 2007). The slowed information processing, insufficient encoding strategies and planning, and attentional setshifting are related to memory deficits and cognitive impairment in PD (Daum et al, 1995;Pillon et al, 1997;Knoke et al, 1998;Robertson & Empson, 1999;Sawamoto et al, 2002;Cools, 2006). Neuropsychological studies of PD patients report cognitive deficits even during the early stages of the disease (van Spaendonck et al, 2006).…”