Memory function and hippocampal volumes in preterm born very-low-birth-weight (VLBW) young adults

Aanes, Synne; Bjuland, Knut Jørgen; Skranes, Jon; Løhaugen, Gro

doi:10.1016/j.neuroimage.2014.10.023

Cited by 71 publications

(73 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The lack of concluding evidence for an association between hippocampal‐related deficits and working memory function in adolescents or adults born VPT (with the exception of Aanes et al. 's study16) gives hope that the apparent transfer of working memory function from subcortical to fronto‐parietal cortex may result in neurodevelopmental adaptation. Functional neural compensation hypotheses are yet to be investigated in relation to memory processing, but promising results are provided by studies of other cognitive functions, such as language, which have suggested the existence of alternative task‐specific neural pathways in the developing preterm brain 49.…”

Section: Resultsmentioning

confidence: 99%

“…It remains to be seen whether these deficits are temporary and reflect the reliance of working memory function on the hippocampus that is seen early in development, or if early hippocampal damage disrupts subsequent neurodevelopment in brain areas sub‐serving working memory processing that can then result in permanent functional deficits. Interestingly, one recent study found a relationship between the volume of the right hippocampus and working memory ability in young adulthood,16 although to date this appears to be the only study to find such a specific link in adulthood. Furthermore, animal data suggest that early anatomical damage to the hippocampus may be sufficient to disrupt typical maturation of the prefrontal cortex and cause a permanent reduction in working memory abilities 39…”

Section: Working Memorymentioning

confidence: 90%

“…Reductions in volume in the hippocampus, as well as the interconnected thalamus and posterior cingulate cortex, are already present at term‐equivalent age and are related to the degree of prematurity 11. Smaller bilateral hippocampal volume in VPT samples compared with controls has been described at school‐age (~9% volume reduction),12, 13 adolescence (~14% volume reduction),14, 15 and adulthood16, 17 although some studies have found no hippocampal volume differences when correcting for factors such as intracranial volume 18, 19. Interestingly, hippocampal volume at term, but not at 7 years of age (or the amount of growth between these time‐points), has been associated with episodic memory abilities at age seven 12, 18, 20.…”

Section: Episodic Memorymentioning

confidence: 99%

See 2 more Smart Citations

Alterations in development of hippocampal and cortical memory mechanisms following very preterm birth

Nosarti

Froudist-Walsh

2016

Develop Med Child Neuro

View full text Add to dashboard Cite

Deficits in memory function have been described in children and adolescents who were born very preterm (VPT), which can have profound effects on their school achievement and everyday life. However, to date, little is known about the development of the neuroanatomical substrates of memory following VPT birth. Here we focus on episodic and working memory and highlight key recent functional and structural magnetic resonance imaging (MRI) studies that have advanced our understanding of the relationship between alterations seen in the VPT brain and typical neurodevelopment of networks supporting these memory functions. We contrast evidence from the episodic and working memory literatures and suggest that knowledge gained from these functional and neuroanatomical studies may point to specific time windows in which working memory interventions may be most effective.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Working Memorymentioning

confidence: 90%

Section: Episodic Memorymentioning

confidence: 99%

See 1 more Smart Citation

Alterations in development of hippocampal and cortical memory mechanisms following very preterm birth

Nosarti

Froudist-Walsh

2016

Develop Med Child Neuro

View full text Add to dashboard Cite

show abstract

“…Structural images were reconstructed using FreeSurfer, an automated segmentation tool that has been demonstrated to label structures comparably to manual tracing techniques (20). Although visual inspection is commonly used to qualitatively examine the quality of structural MRI data, more recent techniques have additionally allowed for quantitative measurements of anatomical data quality (38,39). To assess data quality in an unbiased manner, Freesurfer's QA tools (https://surfer.nmr.mgh.harvard.edu/fswiki/ QATools) were used to calculate signal-to-noise ratios for each subject as well as to generate a series of screenshots taken from various steps throughout the reconstruction pipeline.…”

Section: Methodsmentioning

confidence: 99%

Genetic risk for obesity predicts nucleus accumbens size and responsivity to real-world food cues

Rapuano

Zieselman

Kelley

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

Obesity is a major public health concern that involves an interaction between genetic susceptibility and exposure to environmental cues (e.g., food marketing); however, the mechanisms that link these factors and contribute to unhealthy eating are unclear. Using a well-known obesity risk polymorphism (FTO rs9939609) in a sample of 78 children (ages 9-12 y), we observed that children at risk for obesity exhibited stronger responses to food commercials in the nucleus accumbens (NAcc) than children not at risk. Similarly, children at a higher genetic risk for obesity demonstrated larger NAcc volumes. Although a recessive model of this polymorphism best predicted body mass and adiposity, a dominant model was most predictive of NAcc size and responsivity to food cues. These findings suggest that children genetically at risk for obesity are predisposed to represent reward signals more strongly, which, in turn, may contribute to unhealthy eating behaviors later in life.T he relationship between genes and sensitivity to environmental cues is elusive, yet it is paramount to understanding the development of potentially maladaptive human behaviors. The rising prevalence of obesity is a major public health concern that has been attributed to various factors, such as genetic susceptibility (1), and increases in the availability and marketing of calorie-dense foods (2). However, little is known about how genetic predisposition to obesity influences sensitivity to real-world food cues and contributes to the development of unhealthy eating behaviors.Previous neuroimaging studies have demonstrated that responses to food cues in reward-related regions of the brain, such as the nucleus accumbens (NAcc), predict weight gain in adulthood (3) and giving in to food temptations in daily life (4). Furthermore, structural differences in NAcc volume have been positively associated with body mass index (BMI) in adults (5, 6). Because the development of the NAcc precedes the development of prefrontal control systems (7), this structure is suggested to play a key role in motivating and establishing unhealthy eating behaviors early in the lifespan. Importantly, genetic factors are a known contributor to brain development (8) and may influence risky behaviors during childhood and adolescence by biasing the early development of anatomical structures underlying reward-related brain function.In addition, the notion that genes contribute to obesity has recently gained much attention. More specifically, the fat-mass and obesity-associated (FTO) rs9939609 polymorphism has been strongly related to increased BMI and adiposity across the lifespan, and is suggested to influence food intake and food choice, rather than energy expenditure (9-11). Those with two high-risk "A" alleles (AA) are at an enhanced risk for obesity compared with those with two low-risk "T" alleles (TT) or those who are heterozygous (AT) for the FTO rs9939609 polymorphism. Although the FTO gene is highly expressed in the brain (1), the mechanism by which this gene promotes unhealthy...

show abstract

“…S. Aanes и соавт. [21] с помощью магнитно-резонансной то-мографии (МРТ) и шкалы памяти IQ-теста Векслера (WAIS-III), опираясь на МРТ-данные о сниженном объеме гиппокампа у родившихся глубоконедоно-шенными подростков, дефиците рабочей памяти и в целом когнитивных способностей, провели исследо-вание молодых людей в возрасте 19-20 лет. Авторы выявили снижение индексов памяти, в частности: а) зрительной и слуховой памяти в структуре так на-зываемой иконической памяти (immediate memory), отвечающей за непосредственное запечатление ин-формации; б) рабочей, отсроченной зрительной па-мяти и целостной структуры памяти (visual delayed and general memory delayed indices), без отличий от-сроченной слуховой памяти и слухового распознава-ния.…”

Section: российский вестник перинатологии и педиатрии 1 2016 Rossiyunclassified

Long-term impact of prematurity on postnatal neurohormonal regulation

Зиборова¹,

Кешишян²,

Сахарова³

2016

Ross. vestn. perinatol. pediatr.

View full text Add to dashboard Cite

Memory function and hippocampal volumes in preterm born very-low-birth-weight (VLBW) young adults

Cited by 71 publications

References 53 publications

Alterations in development of hippocampal and cortical memory mechanisms following very preterm birth

Alterations in development of hippocampal and cortical memory mechanisms following very preterm birth

Genetic risk for obesity predicts nucleus accumbens size and responsivity to real-world food cues

Long-term impact of prematurity on postnatal neurohormonal regulation

Contact Info

Product

Resources

About