2008
DOI: 10.1016/j.pnpbp.2008.05.004
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Memory impairment induced by low doses of reserpine in rats: Possible relationship with emotional processing deficits in Parkinson disease

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Cited by 26 publications
(15 citation statements)
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“…Our results are also in agreement with other findings showing that the reserpine model is characterized not only by behavioral depression but also by impairment of monoamine neurotransmission in the brain (Colpaert 1987; Gerlach and Riederer 1996; Fernandes et al 2008, 2012). Previous in vitro studies have shown that the investigated compounds, TIQ and 1MeTIQ, possess free radical scavenging capacity and intrinsic antioxidant properties (Antkiewicz-Michaluk et al 2006).…”
Section: Discussionsupporting
confidence: 93%
“…Our results are also in agreement with other findings showing that the reserpine model is characterized not only by behavioral depression but also by impairment of monoamine neurotransmission in the brain (Colpaert 1987; Gerlach and Riederer 1996; Fernandes et al 2008, 2012). Previous in vitro studies have shown that the investigated compounds, TIQ and 1MeTIQ, possess free radical scavenging capacity and intrinsic antioxidant properties (Antkiewicz-Michaluk et al 2006).…”
Section: Discussionsupporting
confidence: 93%
“…These findings are in accordance with early PD symptomatic description, as executive function, attention deficit and episodic and procedural memory impairment have been described . Furthermore, acute administration of low dose of reserpine resulted in emotional processing deficits in aversive memory tasks, such as context conditioning and discriminative avoidance task, but not motor impairment. In parallel, immobility in the forced swim test correlated with pain indexes, indicating a comorbid relationship between different reserpine‐induced nonmotor symptoms .…”
Section: Motor and Nonmotor Behavioral Impairment In The Reserpine Modelsupporting
confidence: 89%
“…The spontaneous alternation test (SA) was used to evaluate spatial working memory (Lalonde, 2002) and was performed in accordance with a previous study (Fernandes et al, 2008). Rats were individually placed in a plus-maze with open top and four arms with high walls (47 × 11 × 45 cm) extending from a central platform (16 × 16 cm).…”
Section: Spontaneous Alternationmentioning
confidence: 99%