Memory-improving action of glucose: indirect evidence for a facilitation of hippocampal acetylcholine synthesis

Messier, Claude; Durkin, Thomas; Mrabet, Oulaya; Destrade, Claude

doi:10.1016/0166-4328(90)90100-s

Cited by 111 publications

(57 citation statements)

References 33 publications

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“…As mentioned previously, this procedure has been more typically employed in animal studies investigating glucose modulation of memory (e.g. Gold, 1986;Greenwood and Winocur, 2001;Messier, 1997;Messier et al, 1990;Salinas and Gold, 2005;Stone et al, 1992;Winocur, 1995;Winocur and Gagnon, 1998), whereas human studies typically involve the administration of a standard glucose dose that does not account for body weight. This may be a critically important factor in determining whether glucose ingestion modulates cognitive performance, as glucoregulatory efficiency differs between individuals of different body weights.…”

Section: The Dose-response Relationshipmentioning

confidence: 99%

“…This line of research originated from evidence that glucose metabolism is involved in the synthesis of ACh (Messier, 2004). Early animal work reported that administration of glucose attenuated the amnesic effect of scopolamine injection (Durkin et al, 1992;Messier et al, 1990). …”

Section: Ach Synthesismentioning

confidence: 99%

“…Further, a sodium-dependent high-affinity choline uptake assay (Messier et al, 1990) and in vivo microdialysis (Durkin et al, 1992) suggested that this finding was mediated by increased ACh synthesis.…”

Section: Ach Synthesismentioning

confidence: 99%

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Glucose enhancement of human memory: A comprehensive research review of the glucose memory facilitation effect

Smith

Riby

Eekelen

et al. 2011

Neuroscience & Biobehavioral Reviews

134

123

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The brain relies upon glucose as its primary fuel. In recent years, a rich literature has developed from both human and animal studies indicating that increases in circulating blood glucose can facilitate cognitive functioning. This phenomenon has been termed the 'glucose memory facilitation effect'. The purpose of this review is to discuss a number of salient studies which have investigated the influence of glucose ingestion on neurocognitive performance in individuals with a) compromised neurocognitive capacity, as well as b) normally functioning individuals (with a focus on research conducted with human participants). The proposed neurocognitive mechanisms purported to underlie the modulatory effect of glucose on neurocognitive performance will also be considered. Many theories have focussed upon the hippocampus, given that this brain region is heavily implicated in learning and memory. Further, it will be suggested that glucose is a possible mechanism underlying the phenomenon that enhanced memory performance is typically observed for emotionally laden stimuli.

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Section: The Dose-response Relationshipmentioning

confidence: 99%

Section: Ach Synthesismentioning

confidence: 99%

See 1 more Smart Citation

Glucose enhancement of human memory: A comprehensive research review of the glucose memory facilitation effect

Smith

Riby

Eekelen

et al. 2011

Neuroscience & Biobehavioral Reviews

134

123

View full text Add to dashboard Cite

show abstract

“…13 for a review). It at tenuates scopolamine-induced amnesia in a variety of tasks (11,14). Moreover, it diminishes the decrease in striatal ACh content induced by a cholinergic antagonist (15 These results suggest that a1-adrenergic mechanisms are involved in the paeoniflorin effect.…”

mentioning

confidence: 92%

Comparison of the Anticonflict Effect of Buspirone and Its Major Metabolite l-(2-Pyrimidinyl)-Piperazine (1-PP) in Rats

Ohta

Matsumoto

Watanabe

et al. 1993

Japanese Journal of Pharmacology

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ABSTRACT-Paeoniflorin, a major constituent of peony root (1 mg/kg, p.o.), attenuated scopolamine induced deficit in radial maze performance. Both prazosin (0.5 mg/kg, i.p.) and yohimbine (0.3 mg/kg, i.p.) neither impaired radial maze performance by itself nor augmented the scopolamine-induced performance deficit. Prazosin significantly blocked the antagonizing effect of paeoniflorin on the scopolamine deficit, whereas yohimbine did not affect the paeoniflorin effect. These data suggest that the a,-adrenergic but not a2-adrenergic systems are involved in the antagonizing effect of paeoniflorin on the scopolamine deficit in radial maze performance in rats.

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“…On the other hand, recent evidence suggest that glucose acts as a common mediator of some cognitive enhancers (see 20, for review). Glucose attenuates scopolamine-induced amnesia in the inhibitory avoidance task (8) and an operant bar pressing task (21). In addition, glucose diminishes both the increase in high affinity choline uptake (21) and the decrease in striatal ACh content (22) by cholinergic antagonists.…”

Section: Discussionmentioning

confidence: 99%

Effects of N-Nitro-L-Arginine on Isolated Rabbit Afferent Arterioles

Takahashi

Hasui

Aki

et al. 1993

Japanese Journal of Pharmacology

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ABSTRACT-Paeoniflorin, a major constituent of peony root, has been demonstrated to attenuate the radial maze performance deficit produced by scopolamine. In the present study, to investigate the possible involvement of ~-adrenergic systems in the paeoniflorin antagonism of the scopolamine deficit, the effects of two ~-adrenoceptor antagonists, propranolol and atenolol, on the paeoniflorin effect were examined in male Wistar rats. Paeoniflorin (1 mg/kg, p.o.) significantly attenuated the scopolamine HBr (0.3 mg/kg, i.p.) induced deficit in the choice accuracy in radial maze performance without changing the running time pro longed by scopolamine. Neither D,L-propranolol HCl, a lipophilic p-antagonist, at 3 mg/kg, i.p. nor atenolol, a hydrophilic p1-antagonist that is known to hardly ever cross the blood-brain barrier, at 1 mg/kg, i.p. impaired maze performance by itself or aggravated the scopolamine-induced deficit in radial maze per formance. Both antagonists, however, completely blocked the antagonizing effect of paeoniflorin on the scopolamine deficit. These data suggest that the 3-adrenergic systems, especially peripheral ~1-adrenergic systems, are involved in the antagonizing effect of paeoniflorin on the scopolamine deficit in radial maze per formance in rats.

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Memory-improving action of glucose: indirect evidence for a facilitation of hippocampal acetylcholine synthesis

Cited by 111 publications

References 33 publications

Glucose enhancement of human memory: A comprehensive research review of the glucose memory facilitation effect

Glucose enhancement of human memory: A comprehensive research review of the glucose memory facilitation effect

Comparison of the Anticonflict Effect of Buspirone and Its Major Metabolite l-(2-Pyrimidinyl)-Piperazine (1-PP) in Rats

Effects of N-Nitro-L-Arginine on Isolated Rabbit Afferent Arterioles

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