MEMRI Characterization and Quantification Maps of Human Pancreatic Islets

D, Suraj Serai; Leoni, Lara; Haque, Muhammad E; B, Brian Roman

doi:10.7243/2050-0866-1-21

Cited by 1 publication

(1 citation statement)

References 28 publications

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“…Manganese contrast agents offer potential in numerous MRI platforms having been applied to preclinical neuronal assessment,6 lymphocyte and stem cell tracking,9 pancreatic beta cell activation10 and the evaluation of myocardial viability in ischaemia 11. Manganese radiotracers have also been explored in positron emission tomography 12.…”

Section: Historical Perspective: Manganese As a Contrast Agentmentioning

confidence: 99%

Manganese-enhanced MRI of the myocardium

Spath

Thompson

Baker

et al. 2019

Heart

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Gadolinium-based contrast media are widely used in cardiovascular MRI to identify and to highlight the intravascular and extracellular space. After gadolinium, manganese has the second highest paramagnetic moment and was one of the first MRI contrast agents assessed in humans. Over the last 50 years, manganese-enhanced MRI (MEMRI) has emerged as a complementary approach enabling intracellular myocardial contrast imaging that can identify functional myocardium through its ability to act as a calcium analogue. Early progress was limited by its potential to cause myocardial depression. To overcome this problem, two clinical formulations of manganese were developed using either chelation (manganese dipyridoxyl diphosphate) or coadministration with a calcium compound (EVP1001-1, Eagle Vision Pharmaceuticals). Preclinical studies have demonstrated the efficacy of MEMRI in quantifying myocardial infarction and detecting myocardial viability as well as tracking altered contractility and calcium handling in cardiomyopathy. Recent clinical data suggest that MEMRI has exciting potential in the quantification of myocardial viability in ischaemic cardiomyopathy, the early detection of abnormalities in myocardial calcium handling, and ultimately, in the development of novel therapies for myocardial infarction or heart failure by actively quantifying viable myocardium. The stage is now set for wider clinical translational study of this novel and promising non-invasive imaging modality.

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