It is well-known that faster arithmetic operations could be achieved via high-radix numeric systems [1]. However, due to the absence of appropriate storage devices, such a practice was not given much attention so far because it would require memory capacity doubling in order to represent high-radix numbers in binary mode. Moreover, in view of the prospected end of the so called "Moore's law", many new approaches, which aim to extend the applicability of Complementary Metal-Oxide-Semiconductor (CMOS)-based circuits and systems, have been proposed by the semiconductor industry. In fact, Flash memory is approaching fundamental scaling limits due to several reliability issues. Therefore, currently there is a growing interest in new devices for information processing and memory, as well as new technologies and paradigms for system architecture [2][3][4][5][6][7][8][9]. An exciting approach would be the development of a competitive, reliable, multi-level storage cell technology, which will enable storing multiple bits of information in a single memory element [10,11]. Most such approaches so far are based on transistors [2], but the recent discovery of the memristor has renewed the interest for this promising scientific area [12][13][14]. Owing to their analog nature, memristors have a remarkable ability to store multi-bit values in a single cell [15,16]; a property which adds significantly to their potential use in future multi-level storage cell technologies and high-radix arithmetic units [17].Nowadays, there is a notable variety of systems that exhibit memristive behavior [18]. As it was also mentioned in the previous chapters, memristors offer several advantages, such as nonvolatility, rapid switching, low power consumption, and compatibility with conventional CMOS technology. Additionally, they provide an unconventional computation framework, which combines information processing and storage in the memory cell itself; the major distinction from the present computing paradigms [19,20]. Such favorable performance characteristics render them a candidate technology, able to bring the next technological revolution in electronics,