Men born in the region of Leipzig (Saxony, Germany) between 1960 and 1970 showed a significantly decreased sperm count (examination of 3432 individuals)

Paasch, Uwe; Thieme, C.; Glander, H.‐J.

doi:10.1046/j.0303-4569.2003.00590.x

Cited by 7 publications

(6 citation statements)

References 7 publications

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“…However, compared to these other studies we had a slightly lower percentage of normozoospermic cases and a higher proportion of azoospermic cases (Acacio et al, 2000;Chia et al, 1998). Meanwhile, the mean sperm concentration in our study corresponds to values found in another German sample of comparable birth cohorts (Paasch et al, 2003).…”

Section: Influences On Sperm Countsupporting

confidence: 82%

Men with subnormal sperm counts live shorter lives

Groos

Krause

Muêller

2006

Biodemography and Social Biology

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A lost less is known about the morbidity and mortality consequences of male infertility. It was the aim of our study to analyse the association between sperm concentration and individual lifetime mortality in men. The data sources included medical records of 601 men who attended the andrological service at the Marburg University Hospital between 1949 and 1985, and vital data gathered from public registration offices and a statutory health insurance. A Cox regression model estimated a two-fold higher mortality risk for oligozoospermic men as compared to the normozoospermic group for cohorts born between 1892 and 1931. Since a selection bias could not be found, we assume there to be a connection between poor fertility status and a shorter lifespan in men. Possible explanations for the variation in mortality risk are: (i) Lifestyle and health behaviour in adulthood, (ii) conditions in utero, and (iii) genetic dispositions.

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Section: Influences On Sperm Countsupporting

confidence: 82%

Men with subnormal sperm counts live shorter lives

Groos

Krause

Muêller

2006

Biodemography and Social Biology

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“…Furthermore, studies have suggested a decline in semen quality of men from some regions in the east part of Germany e.g. Saxony, Saxony-Anhalt and Berlin (Glockner et al, 1998;Thierfelder et al, 1999;Paasch et al, 2003). The noted decrease may, however, to some extent, be because of a selection bias because a majority of the examined men were from infertile couples, and therefore do not represent the general male population in Germany.…”

Section: Discussionmentioning

confidence: 98%

“…However, some data exist with regard to chemical exposures in Leipzig and Hamburg in general. While Hamburg represents a typical urban West European area, the region of Leipzig has been characterized by an almost immotile population in a heavily polluted environment (Paasch et al, 2003). Factors identified as potentially relevant endocrine disruptors have been used to a varying extent.…”

Section: Discussionmentioning

confidence: 99%

Semen quality in sub‐fertile range for a significant proportion of young men from the general German population: a co‐ordinated, controlled study of 791 men from Hamburg and Leipzig

et al. 2008

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Population studies have shown that a high proportion of Nordic men may have so poor semen quality that they can be classified as sub-fertile according to international standards. A question is whether the Nordic data are specific for the Nordic countries or they should be seen as an expression of a general trend in Europe. We therefore carried out a prospective study of semen quality of young men raised in the former East Germany (Leipzig) and West Germany (Hamburg). To enable inter-regional comparisons, we utilized a common European research protocol previously used in studies in the Nordic-Baltic region. Three hundred and thirty-four young men representative of the general population from Hamburg, and 457 from Leipzig delivered semen samples, underwent physical examinations and provided information on life-style and reproductive health parameters. The study period in Hamburg was February 2003--July 2004, and in Leipzig July 2003--April 2005. No significant differences were observed in sperm concentration (median 46, 42, and 44 million/mL for men from Hamburg, Leipzig and the combined Hamburg-Leipzig group respectively) or total sperm count (154,141 and 149 million), whereas the differences for morphologically normal spermatozoa (9.4 and 8.4%) and motile spermatozoa (67 and 81%) were significantly different. Previously published studies have shown reduced fertility with decreasing sperm concentrations below 40-55 millions/mL and normal sperm morphology below 9-19%. Thus, a large fraction of young German men seem to have impaired semen quality that may reduce their natural fertility. However, it remains to be investigated to what extent poor semen quality contributes to the low German fertility rates.

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“…En cualquier an alisis comparativo factores como la edad, el estado socioeconómico, las diferencias geogr aficas 2,7,9,27,28 , la tendencia temporal 6,8,29,30 , el período de abstinencia, la metodología empleada para el an alisis seminal, el control de calidad interlaboratorio e intralaboratorio y el an alisis estadístico empleado, podrían conducir a la obtención de conclusiones no apropiadas 31,32 . En este sentido, nuestro estudio tuvo presente estas recomendaciones desde su diseño para que cualquier ejercicio de comparación fuera posible.…”

Section: Discussionunclassified