Menace of Hepatitis C virus among multitransfused thalassemia patients in Balasore district of Odisha state in India

Sinha, Mithilesh Kumar; Raghuwanshi, Babita; Mishra, Bijayanimala

doi:10.4103/jfmpc.jfmpc_449_19

Cited by 4 publications

(1 citation statement)

References 13 publications

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“…The countries with a higher prevalence of HCV in the general population had a higher prevalence of HCV among thalassemia patients too. 13 There is high prevalence of HCV in thalassemics in all countries because of the unique profile of HCV with very long window period for antibody development.…”

Section: Discussionmentioning

confidence: 99%

Occurrence of Transfusion Transmitted Infections Among Transfusion Dependent Thalassemia Patients in A Tertiary Care Hospital in India

Lyngdoh

Bagdi

Ghosh³

et al. 2023

Int. J. Hum. Health Sci.

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Background: Blood transfusion is an important treatment modality in the modern health care system; however, transfusion transmitted infections(TTI) could be fatal or life-threatening in some cases.Objective: To determine the occurrence of transfusion transmitted infections among transfusion dependent thalassemia patients and to study the socio-demographic characteristics of the recipients.Methods: This hospital-based descriptive longitudinal studywas conducted between February 2019 and June 2020, on 102 transfusion-dependentthalassaemic patients receiving blood transfusion at Bankura Sammilani Medical College & Hospital, Bankura,West Bengal, India. They were tested for HIV, HBV, HCV, syphilis and malaria by ELISA (Enzyme Linked Immunosorbent Assay) Lisa Scan EM, Merilisa HBsAg, Merilisa HCV, RPR kit and Maleriscan malaria Pf/Pv.Results: Out of 102 patients, 5.90% were positive for TTI. The highest occurrence was found to be of HCV 3.90%. HBV and HIV showed similar occurrence of 0.98% and none came out positive for syphilis or malaria. The highest occurrence of TTI was found among females 66.7%. The average age of the participants was 7.97±3.27years. The average number of blood transfusion received per year was 11.95±2.71units. Majority of the participants belong to low socio- economic group family 62(60.8%). In respect to ethnicity 14.7%were tribal, while 85.3%were non-tribal population.Conclusion: The cause of high prevalence of HCV may be due to donors being asymptomatic in early stages and failure of detection due to window period of infection. More sensitive screening tests should be done for HIV, HBV, and HCV. All donors must be screened by NAT if not possible the patients must be screened for TTI regularly.Thalassemia patients being the most affected, premarital screening for thalassemia should be done.Every patient should be vaccinated with hepatitis B vaccine.International Journal of Human and Health Sciences Vol. 07 No. 02 April’23 Page: 171-175

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Section: Discussionmentioning

confidence: 99%

Occurrence of Transfusion Transmitted Infections Among Transfusion Dependent Thalassemia Patients in A Tertiary Care Hospital in India

Lyngdoh

Bagdi

Ghosh³

et al. 2023

Int. J. Hum. Health Sci.

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Blood transfusion dynamics in Colombia: Unveiling patterns, reactions and survival rates in multitransfused patients

Bermúdez‐Forero,

García‐Otálora

2024

Vox Sanguinis

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Background and ObjectivesThere is no consensus on a universally accepted threshold to categorize a patient as multitransfused. In 2019, Colombia established the definition of a multitransfused patient as someone who has received six or more blood components, irrespective of the time frame. This study aims to delineate the characteristics, adverse transfusion reactions (ATRs, definitions according to the International Society of Blood Transfusion [ISBT]) and survival rates in this population.Materials and MethodsWe performed an analysis from the data of all institutions engaged in blood component transfusions at the national level who notified events to the National Information System of Haemovigilance (SIHEVI‐INS), from January 2018 to December 2022. The selection criteria focused on individuals who not only exhibited ATRs but also received six or more blood components.ResultsAmong the 1,784,428 patients who received 6,637,271 blood components, an average of 3.7 components per patient was noted. Concurrently, 8378 ATRs were reported (12.6 ATRs/10,000 transfused components). Within this cohort, 691 patients met the criteria for multitransfusion. Predominantly women (51.8%), these individuals received between 6 and 14 blood components. Out of the 691 multitransfused individuals who experienced ATR, 541 had an allergic reaction. Conversely, out of the 6479 non‐multitransfused individuals who experienced ATR, 3835 had an allergic reaction (odds ratio: 2.49, 95% confidence interval: 2.06–3.0). Notably, 271 multitransfused individuals (39.2%) were documented as deceased, with 76% succumbing within 12 months of encountering their most recent ATR.ConclusionMultitransfused individuals in Colombia, being a high‐risk group, exhibit a heightened susceptibility to allergic reactions, surpassing the frequency observed in other transfusion populations. This underscores the necessity for tailored medical care specific to this group.

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Prevalence of Transfusion-Transmitted Infections in Multi-Transfused Thalassemia and Sickle Cell Disease Patients: A Single Center Experience from Southern Odisha, India

Behera,

Mishra,

Behera

et al. 2023

Medical Journal of Dr. D.Y. Patil Vidyapeeth

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Background: Repeated transfusion in sickle cell disease (SCD) and transfusion-dependent thalassemia (TDT) patients lead to transfusion-transmitted infections (TTIs). The prevalence, as well as various risk factors for TTIs in these patients, is found to be inconsistent. This study aimed to observe the prevalence, types of infections as well as risk factors for TTIs in a tertiary health care center. Materials and Methods: This observational study was undertaken on both SCD and TDT patients admitted to the hospital for a transfusion. In all patients, the enzyme-linked immunosorbent assay-based test kit was used for the diagnosis of hepatitis C virus (HCV), hepatitis B virus (HBV), and human immunodeficiency virus 1 and 2 (HIV 1 and 2). However, a rapid test kit was used for the diagnosis of malaria and syphilis. Detailed information on age of the patients, duration of transfusion, and number of transfusion as risk factors were recorded. The association of factors with various infections was analyzed statistically. Results: A total of 153 patients were recruited including 49 SCD and 104 TDT patients. Of 153 patients, 25 patients were found to have infections including HCV in 22 (14.38%) patients, HBV in 2 (1.31%) patients, and HIV in 2 patients (1 patient was positive for both HCV and HBV). Out of 25 TTIs patients, 7 patients had SCD and 18 patients had TDT. On the association, only an increased number of transfusion per year was found to be significantly associated with TTIs (P = 0.008) in SCD patients. However, all the risk factors were found to be associated with TTIs except gender in TDT patients. Conclusion: The occurrence of TTIs was found to be associated with older patients, increased number of transfusion per year, and large duration of transfusion. The increasing trend in the TTIs in these patients calls for a shift toward preventive and comprehensive care to reduce the health burden.

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Menace of Hepatitis C virus among multitransfused thalassemia patients in Balasore district of Odisha state in India

Cited by 4 publications

References 13 publications

Occurrence of Transfusion Transmitted Infections Among Transfusion Dependent Thalassemia Patients in A Tertiary Care Hospital in India

Occurrence of Transfusion Transmitted Infections Among Transfusion Dependent Thalassemia Patients in A Tertiary Care Hospital in India

Blood transfusion dynamics in Colombia: Unveiling patterns, reactions and survival rates in multitransfused patients

Prevalence of Transfusion-Transmitted Infections in Multi-Transfused Thalassemia and Sickle Cell Disease Patients: A Single Center Experience from Southern Odisha, India

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