Mendelian and complex genetics of susceptibility and resistance to parasitic infections

Campino, Susana; Kwiatkowski, Dominic P.; Dessein, Alain

doi:10.1016/j.smim.2006.07.011

Cited by 48 publications

(41 citation statements)

References 124 publications

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“…Genetic background appears to play a critical role in influencing aspects of host immunity and hence in determining the susceptibility to and outcome of schistosome infections (30).…”

Section: Genetics and Susceptibility To Schistosome Infectionmentioning

confidence: 99%

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Schistosomiasis in the People's Republic of China: the Era of the Three Gorges Dam

et al. 2010

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SUMMARY The potential impact of the Three Gorges Dam (TGD) on schistosomiasis transmission in China has invoked considerable global concern. The TGD will result in changes in the water level and silt deposition downstream, favoring the reproduction of Oncomelania snails. Combined with blockages of the Yangtze River's tributaries, these changes will increase the schistosomiasis transmission season within the marshlands along the middle and lower reaches of the Yangtze River. The changing schistosome transmission dynamics necessitate a comprehensive strategy to control schistosomiasis. This review discusses aspects of the epidemiology and transmission of Schistosoma japonicum in China and considers the pathology, clinical outcomes, diagnosis, treatment, immunobiology, and genetics of schistosomiasis japonica together with an overview of current progress in vaccine development, all of which will have an impact on future control efforts. The use of synchronous praziquantel (PZQ) chemotherapy for humans and domestic animals is only temporarily effective, as schistosome reinfection occurs rapidly. Drug delivery requires a substantial infrastructure to regularly cover all parts of an area of endemicity. This makes chemotherapy expensive and, as compliance is often low, a less than satisfactory control option. There is increasing disquiet about the possibility that PZQ-resistant schistosomes will develop. Consequently, as mathematical modeling predicts, vaccine strategies represent an essential component in the future control of schistosomiasis in China. With the inclusion of focal mollusciciding, improvements in sanitation, and health education into the control scenario, China's target of reducing the level of schistosome infection to less than 1% by 2015 may be achievable.

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“…Genetic background appears to play a critical role in influencing aspects of host immunity and hence in determining the susceptibility to and outcome of schistosome infections (30).…”

Section: Genetics and Susceptibility To Schistosome Infectionmentioning

confidence: 99%

“…There are several reported associations between the clinical manifestations of chronic schistosomiasis and gene alleles within the major histocompatibility complex (MHC), although no consistent picture has emerged from these studies (30).…”

Section: Susceptibility To Severe Diseasementioning

confidence: 99%

Schistosomiasis in the People's Republic of China: the Era of the Three Gorges Dam

et al. 2010

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“…Schistosomiasis is an infectious disease with a strong genetic component influenced by socioeconomic, environmental and ecological factors (Campino et al 2006). The immune response plays a central role on the development of severe forms of schistosomiasis, although others factors like infection intensity, nutritional status or genetic background of patients may influence the severity of schistosomiasis (Pearce and MacDonald 2002).…”

Section: Introductionmentioning

confidence: 99%

Identifying phenotypes involved in susceptibility to Schistosoma mansoni infection in F1B6CBA mice

Villar

Vicente

Blanco-Gómez

et al. 2014

Acta Parasitologica

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Schistosomiasis is a disease with a strong genetic component influenced by socioeconomic and ecological factors. Epidemiological studies have identified several genetic regions involved in the schistosomiasis susceptibility. However, it is not well known what physiological traits are predisposing to the disease. The study of experimental infections in inbred mouse strains with variable genetic susceptibility to the disease offers a good opportunity to tackle this question. F1B6CBA hybrid between the most divergent strains was infected in order to characterize the immunophenotypes that correlate with the susceptibility of schistosomiasis disease in mice. Complete blood counts and immunophenotype were determined at 0, 3, 6, and 9 weeks post infection. Nine weeks after cercariae exposure, animals were perfused and worm recovery was assessed. A large number of hepatic lesions, a reduction in the eosinophil and basophil count in the acute phase of infection and the decreased number of monocytes, neutrophils and B-lymphocytes are phenotypes associated with increased susceptibility to S. mansoni infection.

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“…For example, genetic variants conferring resistance to malaria, such as alleles in the region of HBB, HBA, FY, CD36, G6PD, etc., were strongly selected among African populations and others where malaria is endemic [77].…”

Section: Infectious Disease and Selection During Pregnancymentioning

confidence: 99%

Many ways to die, one way to arrive: how selection acts through pregnancy

2013

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Mendelian and complex genetics of susceptibility and resistance to parasitic infections

Cited by 48 publications

References 124 publications

Schistosomiasis in the People's Republic of China: the Era of the Three Gorges Dam

Schistosomiasis in the People's Republic of China: the Era of the Three Gorges Dam

Identifying phenotypes involved in susceptibility to Schistosoma mansoni infection in F1B6CBA mice

Many ways to die, one way to arrive: how selection acts through pregnancy

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