2007
DOI: 10.1007/s00125-007-0903-x
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Mendelian randomisation studies of type 2 diabetes: future prospects

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Cited by 10 publications
(12 citation statements)
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“…No previous study is available to demonstrate that this variant is indeed a valid measure of lifelong difference in circulating RBP4 levels. Another limitation is that the sample size in this study may not be big enough to clarify whether small differences in plasma RBP4 levels attributable to the RBP4 variants cause hypertriglyceridemia and provide definite evidence for the causal effect (19). Therefore, further studies on potential functional effect of SNP rs3758538 and genetic association studies with much larger sample sizes are required to provide definite evidence for the causal relationship between circulating RBP4 levels and hypertriglyceridemia.…”
Section: Discussionmentioning
confidence: 92%
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“…No previous study is available to demonstrate that this variant is indeed a valid measure of lifelong difference in circulating RBP4 levels. Another limitation is that the sample size in this study may not be big enough to clarify whether small differences in plasma RBP4 levels attributable to the RBP4 variants cause hypertriglyceridemia and provide definite evidence for the causal effect (19). Therefore, further studies on potential functional effect of SNP rs3758538 and genetic association studies with much larger sample sizes are required to provide definite evidence for the causal relationship between circulating RBP4 levels and hypertriglyceridemia.…”
Section: Discussionmentioning
confidence: 92%
“…It is, therefore, of interest to determine whether elevated circulating RBP4 levels causally contribute to an unfavorable lipid profile and, therefore, to the pathogenesis of cardiovascular disease. This determination can be achieved by Mendelian randomization (19,20), an epidemiological approach for assessing the direction of causality, in an unbiased way, between putative risk factors and a disease. According to Mendelian randomization, genetic variants in the RBP4 gene are randomly transmitted to the offspring and largely free from reverse causation and confounding.…”
mentioning
confidence: 99%
“…Mendelian randomization is a methodological approach that has been proposed to address this problem, where genetic variants associated with intermediate traits (for instance, adiponectin) can be used as unconfounded markers of risk for disease end points (like type 2 diabetes) associated with the intermediate trait (23). The demonstration that common genetic variants associated with variation in LDL cholesterol levels also increase the risk of coronary heart disease provide proof-of-principal for the approach (24).…”
mentioning
confidence: 99%
“…Los PBMI no solo muestran una alta prevalencia de DT2 (8.7 %), pero han evidenciado un aumento más acelerado en esta prevalencia en los últimos 30 años comparados con los países de altos ingresos (PAI) 1 Dentro del contexto de los PAI, la AM ha confirmado e identificado los factores de riesgo endógenos para DT2, incluyendo la obesidad, inflamación sistémica y lípidos en la sangre, y los factores de riesgo exógenos, incluyendo consumo de alcohol y lácteos 8,9 . Por ejemplo, el uso de la AM en una evaluación exhaustiva reciente de la asociación causal entre el IMC y la DT2 produjo …”
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