Mendelian randomization analysis reveals causal effects of food intakes on inflammatory bowel disease risk

Chen, Bingxia; Han, Ze‐Guang; Geng, Lanlan

doi:10.3389/fimmu.2022.911631

Cited by 11 publications

(11 citation statements)

References 43 publications

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“…Furthermore, a one-sample MR study revealed causal association between asthma onset in childhood and reduced IBD risk in adults, which have less statistical power compared to the two-sample approach [31]. Similarly, investigations into food intakes encountered limitations stemming from sample size issues [32]. In our study, we endeavored to mitigate the aforementioned limitations through speci c approaches.…”

Section: Discussionmentioning

confidence: 99%

Genome-wide mendelian randomization reveals causal effects of modifiable risk factors on inflammatory bowel disease

Zhu,

Fan,

Yang

et al. 2024

Preprint

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Background: The timely recognition of risk factors assumes paramount importance in the prevention of IBD. Our objective is to elucidate the relationship between risk factors and IBD risk. Methods: To investigate the associations between 24 modifiable risk factors and IBD, a combination of univariate and multivariate MR analysis methods was employed. The final outcomes were assessed through a comprehensive analysis of three large independent GWAS. To mitigate confounding biases, we conducted univariate MR analysis for each individual factor. Multivariate MR analysis was performed within each group to account for the influence of multiple factors simultaneously. Results: RA, asthma, the intake of cheese spread, carotene, and college or university degree were negatively associated with IBD risk. MS, PSC, AS, alcohol consumption, gut microbiota abundance, smoking, and sweet intake exhibited positive correlation with IBD risk. Type 2 diabetes, omega-3 fatty acids were correlated with reduced IBD risk. Total testosterone levels and albumin exhibited associations with IBD risk. Primary hypertension, body fat percentage, and whole-body fat mass suggested increased IBD risk. Three large-scale GWAS independently confirmed that gut microbiota abundance, primary hypertension, MS, PSC, AS, whole-body fat mass, and body fat percentage exhibited stronger associations with IBD risk. Conversely, omega-3 fatty acids, RA, asthma, type 2 diabetes, and attainment of a college or university degree were related to decreased IBD risk. Conclusions: Such robust evidence has the potential to inform preventive measures for IBD and, notably, illuminate pathways for future research endeavors.

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Section: Discussionmentioning

confidence: 99%

Genome-wide mendelian randomization reveals causal effects of modifiable risk factors on inflammatory bowel disease

Zhu,

Fan,

Yang

et al. 2024

Preprint

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“…Following the procedure of Chen et al [16], for this study, we selected eligible genetic instrumental variables as follows: (1) the SNPs associated with each exposure (AgeSmk, SmkInit, CigDay, LifSmk and DrnkWk) reached a genome-wide significance threshold (P \ 5 9 10 -8 );…”

Section: Selection Of Genetic Instrumentsmentioning

confidence: 99%

Causal Associations Between Tobacco, Alcohol Use and Risk of Infectious Diseases: A Mendelian Randomization Study

et al. 2023

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Introduction:The causal effects of smoking and alcohol use on the risk of infectious diseases are unclear, and it is hard investigate them in an observational study due to the potential confounding factors. The aim of this study was to use Mendelian randomization (MR) techniques to assess the causalities between smoking, alcohol use and risk of infectious diseases. Methods: Univariable and multivariable MR analyses were performed using genome-wide association data for the age of initiation of regular smoking (AgeSmk, N = 341,427), smoking initiation (SmkInit, N = 1,232,091), cigarettes per day (CigDay, N = 337,334), lifetime Hongxiang Zhu and Xiaohui Zhan contributed equally.

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“…However, these observations may have been confounded by unidentified factors, and the causality of the associations was not supported 15 . Randomized controlled trials (RCTs) are the gold standard to determine a causal relationship 16 , 17 , though they are challenging to implement due to ethical constraints. It is often impossible to link specific nutritional interventions to disease outcomes in long-term RCTs because of the difficulty in selecting appropriate control groups and blinding participants and researchers 18 .…”

Section: Introductionmentioning

confidence: 99%

“…A better understanding of how different types of foods affect the risk of NMOSD may help develop more effective prediction, treatment, and prevention strategies. The purpose of this study was to assess the causal relationship between dietary patterns and NMOSD using the MR method 16 .…”

Section: Introductionmentioning

confidence: 99%

Oily fish and raw vegetable consumption can decrease the risk of AQP4-positive neuromyelitis optica spectrum disorders: a Mendelian-randomization study

Wang¹,

Lin²,

Wu³

et al. 2023

Sci Rep

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Neuromyelitis optica spectrum disorders (NMOSD) are severe inflammatory disorders of the central nervous system targeting aquaporin‐4 (AQP4). The risk factors for NMOSD remain to be determined, though they may be related to diet and nutrition. This study aimed to explore the possibility of a causal relationship between specific food intake and AQP4-positive NMOSD risk. The study followed a two-sample Mendelian randomization (MR) design. Genetic instruments and self-reported information on the intake of 29 types of food were obtained from a genome-wide association study (GWAS) on 445,779 UK Biobank participants. A total of 132 individuals with AQP4-positive NMOSD and 784 controls from this GWAS were included in our study. The associations were evaluated using inverse-variance-weighted meta-analysis, weighted-median analysis, and MR-Egger regression. A high consumption of oily fish and raw vegetables was associated with a decreased risk of AQP4-positive NMOSD (odds ratio [OR] = 1.78 × 10−16, 95% confidence interval [CI] = 2.60 × 10−25–1.22 × 10−7, p = 0.001; OR = 5.28 × 10−6, 95% CI = 4.67 × 10−11–0.598, p = 0.041, respectively). The results were consistent in the sensitivity analyses, and no evidence of directional pleiotropy was observed. Our study provides useful implications for the development of AQP4-positive NMOSD prevention strategies. Further research is needed to determine the exact causal relationship and mechanisms underlying the association between specific food intake and AQP4-positive NMOSD.

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Mendelian randomization analysis reveals causal effects of food intakes on inflammatory bowel disease risk

Cited by 11 publications

References 43 publications

Genome-wide mendelian randomization reveals causal effects of modifiable risk factors on inflammatory bowel disease

Genome-wide mendelian randomization reveals causal effects of modifiable risk factors on inflammatory bowel disease

Causal Associations Between Tobacco, Alcohol Use and Risk of Infectious Diseases: A Mendelian Randomization Study

Oily fish and raw vegetable consumption can decrease the risk of AQP4-positive neuromyelitis optica spectrum disorders: a Mendelian-randomization study

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