Mendelian randomization study shows a causal effect of asthma on epilepsy risk

Tang, Peng; Guo, Xiaoqiang; Li, Chong; Li, Rui

doi:10.3389/fimmu.2023.1071580

Cited by 5 publications

(4 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…(19) A recent cohort study including 150,827 patients with asthma showed that the probability of developing epilepsy in patients with asthma was 1.39 times higher than in healthy controls. (11) In a Mendelian randomization (MR) study whether asthma causally contributes to epilepsy susceptibility was investigated and they reported asthma is associated with an increased risk of epilepsy independent of the age onset of asthma (20). The potential reasons for the association between asthma and epilepsy could be due to anoxia and hypocapnia caused by frequent asthma attacks, or perhaps chronic inflammation is a common pathological feature of asthma and epilepsy.…”

Section: Discussionmentioning

confidence: 99%

A survey on the association of seizure disorders with asthma and allergies in children

Sadri,

Madanipour,

Toami

et al. 2024

Eur Ann Allergy Clin Immunol

View full text Add to dashboard Cite

Background. Little is known about the relationship between allergic diseases and seizure disorders including epilepsy. It is hypothesized that inflammation from allergic diseases may predispose children to seizures. the aim of this study is to investigate frequency of seizure disorder in children with asthma and allergy. Methods. A cross-sectional survey study of parents of 1300 children and adolescents under 20 years of age referred to the Allergy and Asthma Clinic of Imam Ali Hospital (Karaj) who were asked to complete a screening questionnaire for seizures in their children. Parents who reported any history of seizures in their children were contacted to answer a second in-depth questionnaire to determine more detail of type, triggers, and treatment of seizures. Results. A total of 705 males (62%) and 433 females (38%) participated in this study, with a mean and standard age of 6.62±4.57 years. Among them, 70.6% had asthma, 15.2% had allergic rhinitis, 5.6% had atopic dermatitis, 3.5% had urticaria, 2.7% had food allergies, 1% had drug allergies, and 1.4% had other allergic diseases. Additionally, 88 patients (7.7%) had a history of doctor-diagnosed seizures, 57 patients (5%) had febrile convulsions, and 15 patients (1.31%) had idiopathic epilepsy. There was no significant relationship found between febrile convulsions, seizures, and epilepsy with the type of allergic diseases. However, a significant association was observed between the number of comorbid allergic diseases in patients with febrile convulsions (OR=1.4, 95% CI: 1.07-1.83, P=0.013).There was also an association between the epilepsy and comorbid allergic diseases number with an odds ratio OR=1.84, 95% CI=0.28-12, however the risk of epilepsy was increased by 0.84 percent but this increase was not significant. Regarding the relation between the number of allergic diseases in parents and idiopathic epilepsy in their children, a significant association was found only for mothers (OR=1.28, 95% CI: 1.04-2.23, P=0.024), but not for fathers (P>0.05). Conclusions febrile convulsion is associated with the .number of comorbid allergic diseases in children and the mother's number of allergic diseases is more related to idiopathic epilepsy in children than the father's. Impact statement:Little is known about the relationship between allergic diseases and seizure disorders. The significance of this study is that number of comorbid allergic diseases in one patient is more related to development of some types of seizures than the type of allergic disease.

show abstract

Section: Discussionmentioning

confidence: 99%

A survey on the association of seizure disorders with asthma and allergies in children

Sadri,

Madanipour,

Toami

et al. 2024

Eur Ann Allergy Clin Immunol

View full text Add to dashboard Cite

show abstract

“…When I 2 <40%, the heterogeneity of results was not significant, while when I 2 >75%, the heterogeneity of results was significant. A random effects model was used when the heterogeneity of results was significant (I^ 2 ≥50%, or p<0.05), and a common effect model was used when it was not significant (I^ 2 <50% and p≥0.05) ( 24 , 37 , 38 ). Since two-way MR analysis was performed between each cytokine and OLP in this study, we used Bonferroni Hochberg correction, i.e., when p<0.00038 (0.05/132), it suggested that the analysis results were significant.…”

Section: Methodsmentioning

confidence: 99%

“…To eliminate possible linkage disequilibrium (LD), the significantly related SNPs we screened should satisfy both r 2 <0.01, and KB>500. In addition, palindromic SNPs containing ambiguous linkages should also be corrected or excluded (21)(22)(23)(24). We uploaded the screened SNPs to the PhenoScanner website (http:// www.phenoscanner.medschl.cam.ac.uk/) to eliminate confounders associated with the outcome.…”

Section: Selection Of Ivsmentioning

confidence: 99%

Inflammatory cytokines and oral lichen planus: a Mendelian randomization study

Chen,

Zhang,

et al. 2024

Front. Immunol.

View full text Add to dashboard Cite

BackgroundInflammatory cytokines have long been considered closely related to the development of oral lichen planus (OLP), and we further explored the causal relationship between the two by Mendelian randomization (MR) method.MethodsWe performed bidirectional MR analyses by large genome-wide association studies (GWAS). The data included a large-scale OLP dataset, as well as datasets of 41 inflammatory cytokines. All data were obtained from the University of Bristol database, which includes 41 inflammatory cytokines, and the GWAS Catalog database, which includes 91 inflammatory cytokines. OLP data were obtained from the Finngen database, which includes 6411 cases and 405770 healthy controls. We used the inverse variance weighted (IVW) method, MR-Egger method, weighted median method, simple mode method and weighted mode method to analyze the causal relationship between inflammatory cytokines and OLP, and we also combined with sensitivity analysis to further verify the robustness of the results. We performed a meta-analysis of positive or potentially positive results for the same genes to confirm the reliability of the final results.ResultsWe primarily used the IVW analysis method, corrected using the Benjamin Hochberg (BH) method. When p<0.00038 (0.05/132), the results are significantly causal; when 0.00038<p<0.05, the results are potentially causal. We found a total of 7 inflammatory cytokines with significant or potential associations with OLP (University of Bristol database: 2, GWAS Catalog database: 5). In the reverse analysis, we found that a total of 30 inflammatory cytokines were significantly or potentially associated with OLP (University of Bristol database: 5, GWAS Catalog database: 25). After sensitivity analysis and meta-analysis, we finally determined that there was a causal relationship between a total of 3 inflammatory cytokines and OLP in the forward analysis, the most significant of which was FGF21 (p=0.02954, odds ratio (OR): 1.113, 95% confidence interval (95%CI): 1.011-1.226). In the reverse analysis, 14 inflammatory cytokines were causally associated with OLP, the most significant of which was PLAU (p=0.00002, OR: 0.951, 95%CI: 0.930-0.973).ConclusionThere is a causal association between OLP and some inflammatory cytokines, which may play an important role in the pathogenesis of OLP and require further attention.

show abstract

“…For IBD, the data were screened and analyzed to enhance the reliability of the results ( P < 5 × 10 –8 ) by referring to multiple publications and developing stricter criteria. [37,38] Meanwhile, we calculated the proportion of phenotypic variation explained and F-statistics for each IV to assess IV strength and avoid weak instrument bias. After removing IVs with low F-statistics (<10), 21 IVs of IBD were retained for further analysis.…”

Section: Methodsmentioning

confidence: 99%

Causal role of immune cells in inflammatory bowel disease: A Mendelian randomization study

Chen,

Li,

Gao

et al. 2024

Medicine

View full text Add to dashboard Cite

Inflammatory bowel disease (IBD) is characterized by an inflammatory response closely related to the immune system, but the relationship between inflammation and IBD remains unclear. We performed a comprehensive 2-sample Mendelian randomization (MR) analysis to determine the causal relationship between immune cell characteristics and IBD. Using publicly available genetic data, we explored the relationship between 731 immune cell characteristics and IBD risk. Inverse-variance weighting was the primary analytical method. To test the robustness of the results, we used the weighted median-based, MR-Egger, simple mode, and mode-based methods. Finally, we performed a reverse MR analysis to assess the possibility of reverse causality. We identified suggestive associations between 2 immune cell traits and IBD risk (P = 4.18 × 10–5 for human leukocyte antigen-DR on CD14+ monocytes, OR: 0.902; 95% CI: 0.859–0.947; for CD39+ CD4+ T cells, P = 6.24 × 10–5; OR: 1.042; 95% CI: 1.021–1.063). Sensitivity analysis results of these immune cell traits were consistent. In reverse MR analysis, we found no statistically significant association between IBD and these 2 cell traits. Our study demonstrates the close connection between immune cells and IBD using MR, providing guidance for future clinical and basic research.

show abstract

Mendelian randomization study shows a causal effect of asthma on epilepsy risk

Cited by 5 publications

References 47 publications

A survey on the association of seizure disorders with asthma and allergies in children

A survey on the association of seizure disorders with asthma and allergies in children

Inflammatory cytokines and oral lichen planus: a Mendelian randomization study

Causal role of immune cells in inflammatory bowel disease: A Mendelian randomization study

Contact Info

Product

Resources

About