Menetrierʼs disease associated with cytomegalovirus infection in children

Cieslak, Theodore J.; Mullett, Christopher T.; Puntel, Robert; Latimer, John S.

doi:10.1097/00006454-199304000-00014

Cited by 43 publications

(24 citation statements)

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“…Diagnosis is typically made by presence of thickened mucosal folds, during an upper gastrointestinal contrast study or upper gastrointestinal endoscopy, or by ultrasound or CT imaging [9–11]. In adults, Ménétrier's disease usually follows a chronic, unremitting course leading to significant morbidity and mortality due to ongoing protein loss and life-threatening gastrointestinal hemorrhage [3, 4]. Ménétrier's disease in children appears to be generally benign and self-limited, with spontaneous resolution and recovery within 5 months [5, 12, 13].…”

Section: Discussionmentioning

confidence: 99%

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Atypical Clinical and Diagnostic Features in Ménétrier's Disease in a Child

Chung

Pittenger

Flomenhoft

et al. 2011

Case Reports in Gastrointestinal Medicine

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Ménétrier's disease is one of the rarest protein-losing gastropathies in childhood. It is characterized clinically by non-specific gastrointestinal symptoms and edema, biochemically by hypoalbuminemia, and pathologically by enlarged gastric folds. In adults, this disease can be devastating with significant morbidity and mortality. In childhood, it is a self-limiting, transient and benign illness. Its treatment is largely supportive with total parenteral nutrition (TPN) while oral intake is encouraged. Acute onset of vomiting in healthy school age children can be initially explained by acute viral gastroenteritis. However, persistent vomiting associated with hematemesis and severe abdominal pain should warrant further work-up. This case report illustrates a self-limiting and rare cause of protein-losing enteropathy called Ménétrier's disease that presented with several variant clinical features not typically described in association with this entity.

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Section: Discussionmentioning

confidence: 99%

“…Generalized edema is less common being present in less than 25% [9]. In contrast, peripheral edema is reported in up to 90% of children [3, 6]. Ascites and pleural effusion can result from pediatric Ménétrier's disease with severe protein loss [4].…”

Section: Discussionmentioning

confidence: 99%

Atypical Clinical and Diagnostic Features in Ménétrier's Disease in a Child

Chung

Pittenger

Flomenhoft

et al. 2011

Case Reports in Gastrointestinal Medicine

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show abstract

“…MD (hypertrophic protein‐losing gastropathy) is a rare illness; since its first description in 1888, around 360 cases have been reported (1), out of which around 60 were among children (2). The aetiology is unknown but gastric CMV infection and transforming growth factor‐alpha overexpression have been implicated in the pathogenesis (3).…”

Section: Discussionmentioning

confidence: 99%

“…Clinical findings among children include oedema, ascites, pleural effusion due to hypoalbuminemia in the absence of malnutrition, renal, hepatic or cardiac disease. Therefore, MD is a diagnosis to be investigated when a patient presents with generalized oedema (1).…”

Section: Discussionmentioning

confidence: 99%

“…The histologic features are similar among adults and children and include foveolar hyperplasia of the gastric mucosa accompanied by mucus hypersecretion and glandular atrophy of the gastric body (2). CMV infection may be detected by the presence of CMV inclusion bodies in the biopsy or by CMV growth from gastric tissue (1). CMV infection has been detected in one third of MD cases among children (1,3).…”

Section: Discussionmentioning

confidence: 99%

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