Menetrier’s disease associated withHelicobacter pylori: three cases with sonographic findings and a literature review

Abstract

Menetrier's disease is a rare cause of protein-losing gastropathy characterised by hypertrophy of the gastric folds. Three cases are reported. Helicobacter pylori was detected by culture and CLO test in two cases and on follow-up gastroscopy in the other. The first two patients were given eradication therapy and hypertrophic gastropathy resolved whereas in the third the disease remitted prior to the eradication treatment. Typical sonographic features were thickened gastric wall with preservation of the wall stratification. A review of the literature found eight cases of Menetrier's disease associated with H. pylori in children and these cases are briefly reviewed. H. pylori infection should be considered in all children with Menetrier's disease and, if isolated, eradication treatment should be administered.

A case of Menetrier’s disease without Helicobacter pylori or hypoalbuminemia

“…The etiology is not well established. Some theories tried to link it to Helicobacter pylori ( H. pylori ) infection [5] and enhanced gastric epidermal growth factor receptor signaling by transforming growth factor-alpha [1] . The clinical picture includes epigastric pain and discomfort, nausea, vomiting and peripheral edema due to low serum albumin levels.…”

Enfermedad de Ménétrier con compromiso gástrico difuso y duodenal: Caso clínico

“…Existen reportes aislados en la literatura de compromiso gástrico difuso y sólo dos reportes con compromiso duodenal: en el primer caso se describe compromiso de fondo gástrico y de mucosa fúndica heterotópica a nivel duodenal, y en el segundo se describe lesiones difusas nodulares que afectan todo el estómago y duodeno proximal, confirmándose histológicamente enfermedad de Ménétrier 6,7 . La etiología de la enfermedad de Ménétrier se desconoce, se han postulado factores infecciosos como citomegalovirus y H. pylori que participarían principalmente en la forma infantil, habitualmente reversible en forma espontánea o secundario al tratamiento de la infección [8][9][10] . La forma adulta se ha relacionado a sobreexpresión gástrica del factor transformador de crecimiento a (TGF-a) que corresponde al ligando del receptor de factor de crecimiento epidérmico (EGFR), lo que va seguido de hiperplasia de células mucosas superficiales, aumento en la producción de mucina, atrofia de células parietales y disminución de la producción de ácido en algunos pacientes 4,11,12 .…”

A Rare Etiology of Abnormally Large Gastric Folds: Menetrier’s Disease

“…It is also noted that enormous secretions of thick mucus and transforming growth factor alpha (TGF-α) contribute towards gastric hypertrophy [3]. Some authors have discussed its linkage to Helicobacter pylori (H. pylori) infection [4].…”

“…e hypertrophy of the foveolar epithelium results in replacement of the normal gastric glandular structure. ese changes mainly occur in the gastric body where gastric glands containing chief cells are located [4]. e disease is diagnosed with clinical features and further laboratory testing including serum albumin levels, EGD, and testing for H. pylori [4,7].…”

“…It is commonly treated with proton pump inhibitors, high protein diet, H. pylori eradication, cetuximab (monoclonal antibody), and somatostatin analog injections octreotide long-acting release [4,6,8]. In severe progressive disease and medically resistant cases, total and partial gastrectomy are required for management.…”