Menhaden fish oil attenuates postpartum depression in rat model via inhibition of NLRP3-inflammasome driven inflammatory pathway

Aziz, Nurul Uyun Abdul; Chiroma, Samaila Musa; Moklas, Mohamad Aris Mohd; Adenan, Mohd Ilham; Ismail, Amin; Basir, Rusliza; Ali, Razana Mohd; Baharuldin, Mohamad Taufik Hidayat

doi:10.1016/j.jtcme.2021.02.007

Cited by 10 publications

(2 citation statements)

References 49 publications

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“…Jialei Zhu et al ( Zhu and Tang, 2020 ) firstly proposed that astrocytic NLRP3 inflammasome was activated in the hippocampus of PPD mouse model. Another study ( Abdul Aziz et al, 2021 ) also showed that increased NF-кB/NLRP3/caspase-1 activity was detected in the hippocampus of PPD rat model. Similarly, a recent study ( Zhai et al, 2022 ) clarified that NLRP3 inflammasome was activated in the hypothalamus of PPD rat model.…”

Section: Inflammatory Pathophysiological Mechanisms In Postpartum Dep...mentioning

confidence: 89%

Inflammatory pathophysiological mechanisms implicated in postpartum depression

2022

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Postpartum Depression (PPD) is a serious psychiatric disorder of women within the first year after delivery. It grievously damages women’s physical and mental health. Inflammatory reaction theory is well-established in depression, and also has been reported associated with PPD. This review summarized the inflammatory pathophysiological mechanisms implicated in PPD, including decreased T cell activation, increased proinflammatory cytokines secretion, active kynurenine pathway, and initiated NLRP3 inflammasome. Clinical and preclinical research are both gathered. Potential therapeutical alternatives targeting the inflammatory mechanisms of PPD were introduced. In addition, this review briefly discussed the differences of inflammatory mechanisms between PPD and depression. The research of inflammation in PPD is limited and seems just embarking, which indicates the direction we can further study. As a variety of risky factors contribute to PPD collectively, therapy for women with PPD should be comprehensive, and clinical heterogeneity should be taken into consideration. As PPD has a predictability, early clinical screening and interventions are also needed. This review aims to help readers better understand the inflammatory pathological mechanisms in PPD, so as to identify biomarkers and potential therapeutic targets in the future.

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Section: Inflammatory Pathophysiological Mechanisms In Postpartum Dep...mentioning

confidence: 89%

Inflammatory pathophysiological mechanisms implicated in postpartum depression

2022

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“…This is an interesting concept, as the Mediterranean diet is characterized by a good balance of n-6 to omega-3 PUFA intake, while more Westernized and high-fat diets involve much higher intake of n-6 PUFAs (Mariamenatu and Abdu, 2021). PUFAs also have additional immunomodulatory and neuroplastic properties, which may be related to their effects on mitochondrial function as discussed in previous sections (Su et al, 2015;Pérez et al, 2018;Abdul Aziz et al, 2021).…”

Section: Polyunsaturated Fatty Acidsmentioning

confidence: 99%

Mitochondrial might: powering the peripartum for risk and resilience

Gorman-Sandler,

Wood,

Cloude

et al. 2023

Front. Behav. Neurosci.

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The peripartum period, characterized by dynamic hormonal shifts and physiological adaptations, has been recognized as a potentially vulnerable period for the development of mood disorders such as postpartum depression (PPD). Stress is a well-established risk factor for developing PPD and is known to modulate mitochondrial function. While primarily known for their role in energy production, mitochondria also influence processes such as stress regulation, steroid hormone synthesis, glucocorticoid response, GABA metabolism, and immune modulation – all of which are crucial for healthy pregnancy and relevant to PPD pathology. While mitochondrial function has been implicated in other psychiatric illnesses, its role in peripartum stress and mental health remains largely unexplored, especially in relation to the brain. In this review, we first provide an overview of mitochondrial involvement in processes implicated in peripartum mood disorders, underscoring their potential role in mediating pathology. We then discuss clinical and preclinical studies of mitochondria in the context of peripartum stress and mental health, emphasizing the need for better understanding of this relationship. Finally, we propose mitochondria as biological mediators of resilience to peripartum mood disorders.

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