Menhaden oil administration to dogs treated with radiation for nasal tumors demonstrates lower levels of tissue eicosanoids

Hansen, Rodney A.; Anderson, C. C.; Fettman, Martin J.; LaRue, Susan M.; Davenport, Deborah J.; Gross, Kathleen L.; Richardson, Kim; Ogilvie, Gregory K.

doi:10.1016/j.nutres.2011.09.018

Cited by 3 publications

(2 citation statements)

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“…Many in vitro studies have been conducted and provide evidence that fatty acids such as docosahexaenoic acid and eicosapentaenoic acid are effective in reducing cancer cell viability through a variety of mechanisms in human cell lines [19][20][21][22][23] ; however, only one in vitro study has been conducted in canine cell lines. 24 One in vivo study investigated supplementation of menhaden oil in dogs with nasal carcinoma and found it may alleviate inflammatory side effects of radiation therapy 25 while another found n-3 PUFA supplementation increased disease-free interval and survival time in dogs with lymphoma; however, arginine was also supplemented in this T A B L E 5 Time spent researching pet health topics, pet nutrition and nutritional supplements, proportion of pet owners feeding nutritional supplements and number of supplements fed per dog in dogs with cancer and healthy dogs from an online dog owner survey regarding diet and supplement use Note: N, number of respondents; %, proportion; IQR, inter-quartile range reported as the range from Q1 to Q3; min, minimum; max, maximum. Significant (Mann-Whitney U test, P < .05) differences between dogs with cancer and healthy dogs are indicated by P values.…”

Section: Discussionmentioning

confidence: 99%

“…Many in vitro studies have been conducted and provide evidence that fatty acids such as docosahexaenoic acid and eicosapentaenoic acid are effective in reducing cancer cell viability through a variety of mechanisms in human cell lines 19‐23 ; however, only one in vitro study has been conducted in canine cell lines 24 . One in vivo study investigated supplementation of menhaden oil in dogs with nasal carcinoma and found it may alleviate inflammatory side effects of radiation therapy 25 while another found n‐3 PUFA supplementation increased disease‐free interval and survival time in dogs with lymphoma; however, arginine was also supplemented in this group and lymphoma staging was based on subjective methodology, both of which greatly limits interpretation of the results 26 . Since n‐3 FA supplements have also been previously reported at a high frequency among healthy animals, it is possible that other conditions, such as those impacted by aging, may be confounding reasons to administer these and other supplements that were highly reported among the dogs with cancer.…”

Section: Discussionmentioning

confidence: 99%

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Unconventional diets and nutritional supplements are more common in dogs with cancer compared to healthy dogs: An online global survey of 345 dog owners

Bianco

Abood

Mutsaers

et al. 2020

Vet Comparative Oncology

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This survey aimed to investigate and compare diet type and supplement use between dogs (Canis lupus familiaris, L.) with cancer and a population of owner-reported healthy dogs and to assess the sources of information dog owners consult. Respondents were mainly from English-speaking countries. Dogs were considered healthy (N = 213) if owners reported them to be in good health. Dogs were included in the cancer group (N = 132) if the owner reported that their dog had been diagnosed with cancer. An online survey was distributed to clients presenting to a tertiary oncology service, clients presenting to a local primary care veterinary practice, and through social media. Owners of dogs with cancer spent more time researching pet health (P < .001), pet nutrition (P < .01) and nutritional supplements (P < .001) than owners of healthy dogs. While veterinarians were most commonly reported to be an information source for both groups, owners of healthy dogs more likely consulted pet stores and owners of dogs with cancer tended more to social media groups and blogs. Healthy dogs were more likely fed commercial dry food (P < .001), whereas homemade cooked (P < .001) and raw diets (P < .05) were more prevalent among dogs with cancer. Supplement use, especially cannabidiol products, mushroom extracts or turmeric/curcumin, was also more common for this group (P < .001). Alternative diets and supplements were more popular among owners of dogs with cancer compared to owners of healthy dogs. These findings highlight the need for nutritional counselling and education of pet owners regarding nutrition-related topics, especially when their dog is diagnosed with cancer.

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Section: Discussionmentioning

confidence: 99%

“…Many in vitro studies have been conducted and provide evidence that fatty acids such as docosahexaenoic acid and eicosapentaenoic acid are effective in reducing cancer cell viability through a variety of mechanisms in human cell lines 19‐23 ; however, only one in vitro study has been conducted in canine cell lines 24 . One in vivo study investigated supplementation of menhaden oil in dogs with nasal carcinoma and found it may alleviate inflammatory side effects of radiation therapy 25 while another found n‐3 PUFA supplementation increased disease‐free interval and survival time in dogs with lymphoma; however, arginine was also supplemented in this group and lymphoma staging was based on subjective methodology, both of which greatly limits interpretation of the results 26 . Since n‐3 FA supplements have also been previously reported at a high frequency among healthy animals, it is possible that other conditions, such as those impacted by aging, may be confounding reasons to administer these and other supplements that were highly reported among the dogs with cancer.…”

Section: Discussionmentioning

confidence: 99%