Meningeal Involvement in Multiple Myeloma

Cavanna, Luigi; Invernizzi, Rosangela; Bertè, Raffaella; Buscarini, L

doi:10.1159/000333918

Cited by 25 publications

(12 citation statements)

References 17 publications

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“…Involvement of the cereberospinal fluid and meninges with myeloma is extremely rare and only 38 cases have been reported in the literature (Cavanna et al 1995). The immunoglobulin types most frequently reported are IgG and IgA (Cavanna et al 1995). Unlike our patient most have circulating plasma cells at the time meningeal disease is diagnosed and four of the 38 patients had a diagnosis of plasma cell leukaemia (Cavanna et al 1995).…”

Section: Discussionmentioning

confidence: 54%

“…Patients may present with spinal cord 189 or root compression as a result of vertebral collapse or extra dural lesions. The immunoglobulin types most frequently reported are IgG and IgA (Cavanna et al 1995). Involvement of the cereberospinal fluid and meninges with myeloma is extremely rare and only 38 cases have been reported in the literature (Cavanna et al 1995).…”

Section: Discussionmentioning

confidence: 99%

“…Occasionally patients present with polyneuropathy secondary to amyloidosis or as part of POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammapathy and skin changes) (Peest & Deicher 1996). Involvement of the cereberospinal fluid and meninges with myeloma is extremely rare and only 38 cases have been reported in the literature (Cavanna et al 1995). The immunoglobulin types most frequently reported are IgG and IgA (Cavanna et al 1995).…”

Section: Discussionmentioning

confidence: 99%

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Meningeal myeloma in the absence of systemic disease, and as the initial feature of disease progression

Somers

Shaw

Lyn

et al. 1998

Clinical &Amp; Laboratory Haematology

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Section: Discussionmentioning

confidence: 54%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Meningeal myeloma in the absence of systemic disease, and as the initial feature of disease progression

Somers

Shaw

Lyn

et al. 1998

Clinical &Amp; Laboratory Haematology

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“…Sensory disturbances are rare. Accurate diagnosis of myelomatous meningitis is made on CSF examination by demonstration of plasma cells 7 , monoclonal spikes on electrophoresis 7 and monoclonal immunoglobulin in the cytoplasm of plasma cells. 8 The treatment of meningeal myeloma has not been established.…”

Section: Discussionmentioning

confidence: 99%

Myelomatous Meningitis- a case report and review of literature

K¹,

Bajpai²

2014

IOSRJDMS

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“…Multiple myeloma, the most common plasma cell dyscrasia (with approximately 20,000 new cases diagnosed each year in the U.S.), is frequently accompanied by neurologic complications, most often peripheral neuropathies (both disease‐related and treatment‐related) and epidural spinal cord compression. Neoplastic meningitis secondary to multiple myeloma, so‐called myelomatous meningitis (MM), is rare and to our knowledge has been infrequently reported 1–8…”

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confidence: 99%

Myelomatous meningitis

Chamberlain

Glantz

2008

Cancer

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Objective: To compare access site complications with the Micropuncture® 21 gauge (G) needle set to the standard 18G needle in patients undergoing percutaneous coronary intervention (PCI) using the femoral approach. Background: Vascular access site complications are the most common problems after PCI. The Micropuncture 21G needle set was recently introduced to minimize such complications. Methods: A cohort of 3,243 consecutive patients was studied. Patients receiving thrombolytics, IIb/IIIa antagonist, coumadin, or intra‐aortic balloon pump were excluded. Micropuncture access was used in 544 patients and standard 18G needle in 2,699. All access sites were managed with a vascular closure device. Primary endpoints included vascular perforation or limb ischemia requiring repair, retroperitoneal bleeding, pseudoaneurysm, arteriovenous fistula, and groin hematoma (>4 cm). Results: Patients undergoing PCI with Micropuncture were at higher risk: they were older (65.9 ± 9 vs. 64.7 ± 11.8, P = 0.03); had lower body surface area (1.9 ± 0.2 vs. 2.0 ± 0.3, P = 0.02); more prevalent peripheral vascular disease [119 (21.9%) vs. 380 (14.1%), P < 0.001] and renal failure [106 (19.6%) vs. 318 (11.8%), P < 0.001]. Overall, there was no significant difference in the access site complications rate using Micropuncture vs. standard needle, 7 (1.3%) vs. 27 (1.0%), respectively, P = 0.54. The Micropuncture group had significantly higher retroperitoneal bleeding, 0.7% vs. 0.18%, P = 0.04. After multivariable adjustment, only age remained significantly associated with vascular complications (OR 1.03, P = 0.04). Conclusions: Femoral access using the Micropuncture technique did not reduce the incidence of vascular complications and the marginally higher than expected retroperitoneal bleeding is based on very small numbers. The routine use of the Micropuncture set and its technique should be revisited. © 2012 Wiley Periodicals, Inc.

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Meningeal Involvement in Multiple Myeloma

Cited by 25 publications

References 17 publications

Meningeal myeloma in the absence of systemic disease, and as the initial feature of disease progression

Meningeal myeloma in the absence of systemic disease, and as the initial feature of disease progression

Myelomatous Meningitis- a case report and review of literature

Myelomatous meningitis

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