Meningeal myofibroblastoma in the frontal lobe: A case report

Abstract

Myofibroblastoma is a benign tumor composed of spindle cells in clusters and fascicles. To date, only three cases of intracranial myofibroblastoma have been reported. The present study reports the case of a 47-year-old female with meningeal myofibroblastoma. The patient had a history of ovarian cyst resection and presented with paroxysmal mild headaches that had been apparent for 4 years. Magnetic resonance imaging disclosed a well-circumscribed mass in the left frontal lobe. A resection of the mass was performed. Abundant fascicular clusters of spindle- and oval-shaped cells were found by conventional histopathology. Immunohistochemical staining demonstrated that these cells were strongly positive for smooth muscle actin, weakly positive for epithelial membrane antigen and negative for cluster of differentiation (CD)117, CD34, S-100 or desmin, with a Ki-67 index of >10%. These results supported the diagnosis of myofibroblastoma. No recurrence of the mass was found during the 24-month follow-up period. Overall, the patient exhibited a rare type of meningeal neoplasm. Resection of the tumor proved to be successful and no recurrence were found. Histopathological and immunohistochemical staining is crucial to form a diagnosis. To the best of our knowledge, the present study is the first to show the presence of myofibroblastoma in the left frontal lobe.

Mammary-type myofibroblastoma of the psoas

“…In addition, MRI with T1/T2 imaging can demonstrate adipose tissue. The value of CT scan and MRI in the diagnosis of myofibroblastoma has been described by many authors 19 23. The most appropriate diagnostic test for a clinically or radiologically evolving soft tissue mass is a biopsy, due to suspicion of sarcoma.…”

Mammary myofibroblastoma in the right lateral abdominal wall

“…The histopathologic changes associated with extramammary myofibroblastomas often include abundant fascicular clusters of spindle- and oval-shaped cells, which are arranged in interlaced or swirled patterns [ 4 ]. The above characteristic was also detected in our patient.…”

“…Xu et al [ 4 ] indicate that CT and MRI are useful imaging methods in the diagnosis of myofibroblastoma. Shinojima et al [ 11 ] described myofibroblastoma as a low- or mixed low- and high-density mass on CT, which was similar with CT of our present patient.…”

“…Reactivity to factor VIII-related antigen (a marker of endothelial cells), EMA, MAK-6 (cytokeratin; a marker of epithelial cells and meningeal cells), and glial fibrillary acidic protein is negative [ 3 , 12 , 13 ]. Extramammary myofibroblastomas are weakly positive for desmin and CD34 [ 4 , 11 ]. In the present case, immunohistochemical staining was SMA-positive, S-100-negative, CD34-negative, and Ki67+ <1 %.…”

“…Previous reports [ 2 , 3 ] have suggested that the inguinal/groin region is the usual site for extramammary myofibroblastomas. The tumor usually consists of spindle cells [ 4 ] and lacks genetic material in the 13q14 region [ 5 ]. This is the second case report of a myofibroblastoma on the abdominal wall.…”