Meningeoma pós-radioterapia

Barboza, Erick de Souza; Panagopoulos, Alexandros; Lancellotti, Carmen Lúcia Penteado; Veiga, José Carlos Esteves

doi:10.1590/s0004-282x2006000500017

Cited by 5 publications

(7 citation statements)

References 26 publications

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“… 70 Loss of 22q is noted in RIM as well, albeit at a lower rate than sporadic meningiomas. 69 Similarly, mutations in other genes typically associated with meningiomas, including AKT1, SMO, TRAF7, ARID1A, HRAS, KRAS, and NRAS are uncommon in RIM. 70 In contrast, mutations in p53 and PTEN and losses of 1p, 9q, 19q, 18q, and 10p have been reported in RIM ( Table 2 ).…”

Section: Etiology Presentation and Imagingmentioning

confidence: 99%

“…Where “∘” is listed without a specific genetic abnormality, chromosomal alterations without identified candidate genes are listed in parentheses. Represents a sysnthesis of Riemenschneider et al, Umansky et al, Bachir et al, Casalone et al, Zhu et al, Stangl et al, Larson et al, Shen et al, Suppiah et al, Lomas et al, Torres-Martin et al, Heinrich et al, Christiaans et al, Hadfield et al, Smith et al, Garaci et al, Riant et al, Aavikko et al, Kohashi et al, Shoshan et al, Barboza et al, Agnihotri et al, Kimura et al, Petrilli et al 18 , 20 , 22 , 24 , 30 , 32 , 42–53 , 66 , 69–72 …”

Section: Etiology Presentation and Imagingmentioning

confidence: 99%

“…Meningiomas are the most common ionizing radiation-induced neoplasm, but the etiology is unclear, although relative susceptibility of arachnoid cap cells to radiation has been suggested. 20 , 69 Ionizing radiation induces hydroxyl free radical generation, causing DNA damage, with faulty DNA repair resulting in point mutations, translocations, and gene fusions, alongside direct ionizing radiation-induced DNA damage. 20 , 70 Although higher doses of radiation of 22–87 Gy have been associated with RIM with latencies of 19.5 years, even lower doses of 1–2 Gy, such as used to treat tinea capitis and for dental X-rays can be associated with a 9.5-fold increased risk of RIM with latencies of 12–49 years.…”

Section: Etiology Presentation and Imagingmentioning

confidence: 99%

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Multiple meningiomas: Epidemiology, management, and outcomes

Fahlström

Dwivedi

Drummond

2023

Neuro-Oncology Advances

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Meningiomas are the most common nonmalignant brain tumor in adults, with an increasing incidence of asymptomatic meningiomas diagnosed on more ubiquitous neuroimaging. A subset of meningioma patients bear 2 or more spatially separated synchronous or metachronous tumors termed “multiple meningiomas” (MM), reported to occur in only 1%–10% of patients, though recent data indicate higher incidence. MM constitute a distinct clinical entity, with unique etiologies including sporadic, familial and radiation-induced, and pose special management challenges. While the pathophysiology of MM is not established, theories include independent origin in disparate locations through unique genetic events, and the “monoclonal hypothesis” of a transformed neoplastic clone with subarachnoid seeding precipitating numerous distinct meningiomas. Patients with solitary meningiomas carry the risk of long-term neurological morbidity and mortality, as well as impaired health-related quality of life, despite being a generally benign and surgically curable tumor. For patients with MM, the situation is even less favorable. MM should be regarded as a chronic disease, and in many cases, the management goal is disease control, as cure is seldom possible. Multiple interventions and lifelong surveillance are sometimes necessary. We aim to review the MM literature and create a comprehensive overview, including an evidence-based management paradigm.

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Section: Etiology Presentation and Imagingmentioning

confidence: 99%

Section: Etiology Presentation and Imagingmentioning

confidence: 99%

Section: Etiology Presentation and Imagingmentioning

confidence: 99%

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Multiple meningiomas: Epidemiology, management, and outcomes

Fahlström

Dwivedi

Drummond

2023

Neuro-Oncology Advances

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“…iRRadiatiOn -There are a number of reports revealing the appearance of meningiomas after radiotherapy treatment. Approximately 30% of the cases presented by harrison et al were multiples meningiomas [15][16][17][18] . even with a low-dose therapy, as the one used for children, for tinea capitis treatment 19 .…”

Section: Relevant Etiological Factorsmentioning

confidence: 99%

Multiple intracranial meningiomas: diagnosis, biological behavior and treatment

Lynch

Ferreira

Welling

et al. 2008

Arq. Neuro-Psiquiatr.

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-Multiple intracranial meningiomas (MIM) are a rare pathology when not associated with neurofibromatosis. The prevalence rate of those tumors varied from 2.3 to 8.9% of all intracranial meningiomas.Objective: To present, analyze and discuss the cases of seven patients diagnosed with multiple intracranial meningiomas, describing their clinical and histological characteristics, as well as their biological behavior. Method: The patients records, surgical descriptions, imaging studies and the histopathological exams were retrospectively reviewed. This is the largest series of MIM publisted in Brazil. Results: This sample consists of five women and two men. The age varied from 42 to 84 (average 53.8). Twenty-two meningiomas were identified and varied from 1.5 to 192 cm 3 , with an 62.8 cm 3 average volume. The number of procedures varied from 1 to 5 per patient. No surgical death occurred in this series. Conclusion: Despite the multiplicity of tumors, number of recurrences, the new tumors, repeated operations and re-operations, radiotherapy and a number of postoperative complications, the patients experienced a long survival in conjunction with a fairly good quality of life.Key WorDs: brain tumors, meningiomas, multiple intracranial meningiomas, microneurological surgery. Meningiomas intracranianos múltiplos: diagnóstico, comportamento biológico e tratamentoResumo -os meningiomas intracranianos múltiplos são tumores raros quando não associados a neurofibromatose, correspondem de 2,3 a 8,9% de todos os meningiomas intracranianos. Objetivo: Apresentar, analisar e discutir 7 pacientes com diagnóstico de meningioma intracraniano múltiplo, descrevendo as características clínicas, histológicas e o comportamento biológico desses tumores. Método: Trata-se de revisão retrospectiva incluindo a análise dos prontuários, das descrições cirúrgicas, dos estudos de imagem e do material histopatológico. esta série é a maior série de meningiomas intracranianos múltiplos publicada no Brasil. Meningiomas are tumors originated from arachnoidal cells present in the villi, in the granulations, in the stroma of the perivascular spaces and in the choroid plexus; corresponding to 13 to 20% of all intracranial tumors [1][2][3] . Multiple intracranial meningiomas (MIM), when not associated with neurofibromatosis, are a rare event, which corresponding to 2.3 to 8.9% of all intracranial meningiomas [4][5][6][7][8][9][10][11] . The multiple intracranial meningiomas terminology should be used only when two or more meningiomas occur either simultaneously or sequentially in different locations. It is important to establish the difference between this pathology and tumor recurrence or diffuse meningiomatosis 1,3,4,[7][8][9][10] . our study aims presenting, analyzing and discussing 7 patients diagnosed with multiple intracranial meningiomas, describing their clinical, radiological, and histological characteristics, as well as their biological behavior. It also highlights the fact that, although the patients underwent a number of surgeries and ...

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“…Entretanto, as alterações reativas tendem a ser lineares enquanto o resíduo tumoral apresenta-se de forma nodular. Com o aumento da taxa de recorrência, é recomendado que se realize uma margem ampla de ressecção óssea e da duramáter, podendo haver a complementação deste procedimento com técnicas de radiocirurgia e com o uso de hidroxiuréia em meningiomas benignos irressecáveis e recorrentes, os quais demonstram bastante eficácia, diferente dos meningiomas malignos e atípicos 30,33 .…”

Section: Acompanhamento Evolutivo Dos Meningiomas Por Ressonância Magnéticaunclassified

Diagnóstico e acompanhamento evolutivo dos meningiomas através da ressonância magnética

Pereira

Carneiro

Quixabeira

et al. 2021

RBMC

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Os meningiomas são tumores benignos intracranianos de evolução lenta que se originam nas meninges. Por serem assintomáticos, a maioria desses tumores, geralmente, são de difícil identificação. Entretanto, se não diagnosticados, podem comprimir vasos sanguíneos cerebrais levando ao óbito. A Ressonância Magnética (RM) é um método de imagem vital para o diagnóstico e caracterização desses tumores, particularmente importante para se estabelecer um plano de tratamento oncológico. O objetivo deste estudo foi descrever a importância da RM no diagnóstico e acompanhamento evolutivo dos meningiomas e na caracterização tissular, correlacionando os achados imagenológicos com análises histológicas do tumor. Este estudo constitui uma revisão bibliográfica narrativa. Os meningiomas são, geralmente, isointensos em T1 e T2, com variações ligadas à textura mais ou menos compacta ou hidratada do tecido, associados à presença de cistos, calcificações ou metaplasia adiposa. Podem provocar hiperostose, levando ao espessamento do osso afetado. Em imagens ponderadas em T1, pós contraste, os meningiomas, geralmente, aparecem com hipersinal homogêneo. A RM contribui, de forma promissora, para a detecção e caracterização dos meningiomas fornecendo dados prognósticos para o seu tratamento. Um diagnóstico preciso auxilia no acompanhamento evolutivo e pós cirúrgico. Em um período de 24 horas pós cirúrgico, a RM é capaz de identificar resíduos tumorais e recorrências tardias, comuns entre 10 a 20 anos depois da ressecção total do tumor.

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Meningeoma pós-radioterapia

Cited by 5 publications

References 26 publications

Multiple meningiomas: Epidemiology, management, and outcomes

Multiple meningiomas: Epidemiology, management, and outcomes

Multiple intracranial meningiomas: diagnosis, biological behavior and treatment

Diagnóstico e acompanhamento evolutivo dos meningiomas através da ressonância magnética

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