Meningioangiomatosis: A review of the variable manifestations and complex pathophysiology

Tomkinson, Christine; Lu, Jian‐Qiang

doi:10.1016/j.jns.2018.07.018

Cited by 20 publications

(36 citation statements)

References 49 publications

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“…Radiographically, it can present as multifocal tumorlike or cystic lesions, or the brain may appear normal. 105 Human MA has often been reported in association with other lesions of the CNS, most often with an overlying meningioma, 76 as was reported in one dog. 32 This disorder is only described in 12 dogs, 9,32,35,57,79,82,93,101 one horse, 26 one cow, 43 and one mouse, 3 while 3 additional canine cases reside in our archive (unpublished data).…”

Section: Meningioangiomatosismentioning

confidence: 80%

“…Meningioangiomatosis (MA) is a rare, complex, and heterogeneous proliferative disorder with dual meningothelial/fibroblastic and vascular ("meningovascular") components found primarily in the leptomeninges and cerebral cortex in humans, 105 and with a suggested predilection for the brainstem in dogs. 9 The nature of MA remains elusive and it may not be a single pathogenetic entity.…”

Section: Meningioangiomatosismentioning

confidence: 99%

“…Proposed pathogeneses include developmental (often described as hamartomatous), dysplastic, or reactive, rather than neoplastic. 9,105 In humans, MA is typified by a leptomeningeal and neocortical plaque occurring in children and young adults sporadically or in association with neurofibromatosis type 2 (NF2). The most common location is the frontal lobe, followed by the temporal, parietal, and occipital lobes in sporadic MA cases, and can involve subcortical white matter and other brain regions such as the cerebellum and deep gray matter.…”

Section: Meningioangiomatosismentioning

confidence: 99%

“…Canine MA typically lacks the usual calcification, psammoma bodies, and neurofibrillary tangles that are seen with MA in humans. 9,105 Immunohistochemistry yields variable results among MA cases in humans and domestic animals, and only vimentin has been reported to be consistently immunolabeled in the proliferating spindle cells, supporting their mesenchymal origin. 3,9,111 These cells also have variable immunolabeling for a-SMA, suggesting some degree of myofibroblastic differentiation.…”

Section: Meningioangiomatosismentioning

confidence: 99%

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A Review of Proliferative Vascular Disorders of the Central Nervous System of Animals

et al. 2020

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In disease, blood vessel proliferation has many salient roles including in inflammation, when granulation tissue fills superficial defects, or in the recanalization of an occluded blood vessel. Sometimes angiogenesis goes awry—granulation can be exuberant, and plexiform proliferation of vascular components can contribute to pulmonary hypertension. This review focuses on the diverse manifestations of pathologic vascular overgrowth that occur in the brain, spinal cord, and meninges of animals from birth until old age. Entities discussed include systemic reactive angioendotheliomatosis in which glomeruloid vascular proliferations are encountered in various organs including the central nervous system (CNS). The triad of CNS vascular malformations, hamartomas, and benign vascular proliferations are an especially fraught category in which terminology overlap and the microscopic similarity of various disorders makes diagnostic classification incredibly challenging. Pathologists commonly take refuge in “CNS vascular hamartoma” despite the lack of any unique histopathologic features and we recommend that this diagnostic category be abandoned. Malformative lesions that are often confusing and have similar features; the conditions include arteriovenous malformation, cavernous angioma, venous angioma, and capillary telangiectases. Meningioangiomatosis, a benign meningovascular proliferation with dual components, is a unique entity seen most commonly in young dogs. Last, accepted neoplastic conditions range from lower-grade locally acquired growths like hemangioblastoma (a tumor of mysterious interstitial stromal cells encountered in the setting of abundant capillary vasculature proliferation), the rare hemangioendothelioma, and the highly malignant and invariably multifocal metastatic hemangiosarcoma. Additionally, this review draws on the comparative medical literature for further insights into this problematic topic in pathology.

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Section: Meningioangiomatosismentioning

confidence: 80%

Section: Meningioangiomatosismentioning

confidence: 99%

Section: Meningioangiomatosismentioning

confidence: 99%

Section: Meningioangiomatosismentioning

confidence: 99%

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A Review of Proliferative Vascular Disorders of the Central Nervous System of Animals

et al. 2020

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“…AVP is a rare complication after treatment with radiotherapy [ 4 ], usually described after treatment of breast and other gynecological cancers [ 4 , 5 ], and less frequently in other types of neoplasms [ 6 - 9 ]. This complication is included in a spectrum of vascular entities in previously treated sites that includes benign lesions, atypical proliferation, and finally angiosarcoma [ 2 , 10 , 11 ].…”

Section: Discussionmentioning

confidence: 99%