Meningioangiomatosis associated with fibrous meningioma in a dog

Ginel, Pedro J.; Blanco, B.; Pérez, J.; Zafra, R.; Novales, M.; Pérez-Écija, Alejandro

doi:10.1136/vr.164.24.756

Cited by 9 publications

(13 citation statements)

References 11 publications

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“…105 Human MA has often been reported in association with other lesions of the CNS, most often with an overlying meningioma, 76 as was reported in one dog. 32 This disorder is only described in 12 dogs, 9,32,35,57,79,82,93,101 one horse, 26 one cow, 43 and one mouse, 3 while 3 additional canine cases reside in our archive (unpublished data). Previous potentially misidentified cases may include reports of murine meningeal tumors diagnosed as "meningeal sarcoma" 66 and "malignant meningioma," 68 which were so classified based on the pattern of infiltration into brain along the adventitia of small blood vessels.…”

Section: Meningioangiomatosismentioning

confidence: 91%

“…35,57 Cerebrospinal fluid abnormalities have not been described in canine MA, in contrast to most cases of meningiomas, where cerebrospinal fluid alterations are commonly recorded. 32 The prognosis in dogs is generally poor due to degenerative changes caused by the infiltrative nature of the lesions, which makes surgical resection challenging if not impossible. 9 Gross changes may not be apparent externally.…”

Section: Meningioangiomatosismentioning

confidence: 99%

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A Review of Proliferative Vascular Disorders of the Central Nervous System of Animals

et al. 2020

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In disease, blood vessel proliferation has many salient roles including in inflammation, when granulation tissue fills superficial defects, or in the recanalization of an occluded blood vessel. Sometimes angiogenesis goes awry—granulation can be exuberant, and plexiform proliferation of vascular components can contribute to pulmonary hypertension. This review focuses on the diverse manifestations of pathologic vascular overgrowth that occur in the brain, spinal cord, and meninges of animals from birth until old age. Entities discussed include systemic reactive angioendotheliomatosis in which glomeruloid vascular proliferations are encountered in various organs including the central nervous system (CNS). The triad of CNS vascular malformations, hamartomas, and benign vascular proliferations are an especially fraught category in which terminology overlap and the microscopic similarity of various disorders makes diagnostic classification incredibly challenging. Pathologists commonly take refuge in “CNS vascular hamartoma” despite the lack of any unique histopathologic features and we recommend that this diagnostic category be abandoned. Malformative lesions that are often confusing and have similar features; the conditions include arteriovenous malformation, cavernous angioma, venous angioma, and capillary telangiectases. Meningioangiomatosis, a benign meningovascular proliferation with dual components, is a unique entity seen most commonly in young dogs. Last, accepted neoplastic conditions range from lower-grade locally acquired growths like hemangioblastoma (a tumor of mysterious interstitial stromal cells encountered in the setting of abundant capillary vasculature proliferation), the rare hemangioendothelioma, and the highly malignant and invariably multifocal metastatic hemangiosarcoma. Additionally, this review draws on the comparative medical literature for further insights into this problematic topic in pathology.

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Section: Meningioangiomatosismentioning

confidence: 91%

Section: Meningioangiomatosismentioning

confidence: 99%

A Review of Proliferative Vascular Disorders of the Central Nervous System of Animals

et al. 2020

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“…Cats can also develop multiple meningiomas . Meningiomas have also been sporadically reported to occur with other neural disorders including meningioangiomatosis and mucopolysaccharidosis type 1 . Other differential diagnoses for extra‐axial masses in cats include lymphosarcoma, osteosarcoma, and nonneoplastic masses such as granulomas .…”

mentioning

confidence: 99%

Coextensive Meningioma and Cholesterol Granuloma in the Forebrain of a Cat

Chawla¹,

Cook

Himmell

et al. 2015

Veterinary Internal Medicne

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A 9-year-old, female, spayed, domestic longhaired cat presented to The Ohio State University Veterinary Medical Center Oncology Service with a 6-month history of changes in behavior and weight loss. The owner reported that the cat had become abnormally unfriendly and would growl or hiss when touched. The cat also had gait changes, manifested by left hind limb weakness, difficulty walking up stairs, and occasionally losing balance and falling down stairs. The cat was examined by its regular veterinarian and had abdominal radiographs, CBC, and biochemistry profile performed, which did not detect any abnormalities. On physical examination, the cat was underweight with an estimated body condition score (BCS) of 1/5. Neurologic examination revealed a very dull mentation, severe generalized muscle atrophy, and a slow, reluctant, and crouched gait. Cranial nerve examination revealed no abnormalities. There was absence of conscious proprioception in all limbs. A forebrain lesion was suspected. The cat was examined 8 days later because of progressive signs of neurologic disease. The cat was obtunded and had a right head turn with a mild right head tilt. The gait showed proprioceptive/right vestibular ataxia with knuckling of both thoracic limbs on ambulation, a crouched posture, and a splaying outward of the left thoracic limb. There was a decreased menace response bilaterally that was worse on the left and decreased nasal sensation bilaterally. Spinal reflexes were normal in all limbs. Neurolocalization was to the right-forebrain with possible brainstem involvement. An abdominal ultrasound was then performed at the owner’s request to investigate the gastrointestinal tract as a possible explanation for the weight loss, but no abnormalities were identified.

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“…In veterinary medicine, MA was first described in a dog in 1988, 18 with 12 canine cases reported since then. 2,5,6,9,12,13,17,18 Based on limited evidence from these cases, MA appears to affect younger dogs <1-y-old; no apparent breed or sex predisposition has been observed. Clinical signs vary according to the anatomic location of the lesions, with affected dogs displaying seizures and variable neurologic deficits in postural reactions and gait.…”

mentioning

confidence: 97%

“…Meningioangiomatosis (MA) is a rare and poorly understood proliferative lesion of the leptomeninges and superficial neuroparenchyma that has been described mainly in humans and dogs, 2,5,6,9,12,13,17,18 with additional single case reports in a horse, 4 cow, 8 and mouse. 1 MA is a poorly understood lesion.…”

mentioning

confidence: 99%

Encephalic meningioangiomatosis in a cat

et al. 2022

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Meningioangiomatosis (MA) is a rare proliferative meningovascular entity that has been described mainly in humans and dogs. Here we describe MA in a 13-y-old spayed female domestic shorthaired cat that died 5 d after acute change in behavior, open-mouth breathing, seizures, hyperthermia, and inability to walk. On MRI, the lesion appeared predominantly as extraparenchymal hemorrhage. Autopsy changes consisted of a dark-red, hemorrhagic plaque that expanded the leptomeninges and outer neuroparenchyma of the right piriform and temporal telencephalic lobes, chalky white nodules in the peripancreatic fat, and yellow fluid in the abdomen. Histologically, the lesion in the brain consisted of leptomeningeal thickening by spindle cells that effaced the subarachnoid spaces and extended perivascularly into the underlying cerebral cortex. Spindle cells were arranged as streams or whorls around blood vessels, and had slender eosinophilic cytoplasm and elongated nuclei with coarsely stippled chromatin and 1 or 2 distinct nucleoli. There was extensive hemorrhage, clusters of hemosiderin-laden macrophages, and mineralization throughout. Spindle cells had positive immunolabeling for vimentin. A striking MRI and gross feature in our case was the extensive hemorrhage associated with the MA lesion. Additional findings included suppurative pancreatitis with peritonitis and supraspinatus myonecrosis.

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Meningioangiomatosis associated with fibrous meningioma in a dog

Cited by 9 publications

References 11 publications

A Review of Proliferative Vascular Disorders of the Central Nervous System of Animals

A Review of Proliferative Vascular Disorders of the Central Nervous System of Animals

Coextensive Meningioma and Cholesterol Granuloma in the Forebrain of a Cat

Encephalic meningioangiomatosis in a cat

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