Meningioma in Breast Cancer Patients

Milano, Michael T.; Grossman, Craig E.

doi:10.1097/coc.0000000000000052

Cited by 15 publications

(19 citation statements)

References 40 publications

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“…Furthermore, grade of meningiomas cannot be differentiated from NHIRD, and it hinders us to assess if tamoxifen use or not has different effects on different grades of meningioma. Milano et al found that women with both breast cancer and meningioma tended to have more advanced breast cancers and smaller-sized meningiomas compared with women having only one of these diagnoses (Milano and Grossman, 2017); unfortunately, the current study cannot justify it. Second, precise brain MRI and CT information is unavailable in the NHIRD, and the resulting potential surveillance bias precludes a fair comparison of the risk of meningioma in breast cancer patients with that in the normal population.…”

Section: Discussioncontrasting

confidence: 69%

“…The breast cancer–meningioma relationship has been investigated for decades, but the results have been discordant. Several studies have detected a positive association between these two conditions (Schoenberg et al, 1975; Helseth et al, 1989; Lieu et al, 2003; Rakha et al, 2007; Rao et al, 2009; Milano and Grossman, 2017). For example, Rao et al found a strong association between breast cancer and meningioma, but only in women (Rao et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

“…The rate of meningioma incidence in women is nearly two times that in men, especially during the reproductive period of life (Claus et al, 2008; Wiemels et al, 2010; Ostrom et al, 2015). Breast cancer in women has been associated with meningioma (Helseth et al, 1989; Lieu et al, 2003; Rao et al, 2009; Milano and Grossman, 2017). Approximately 66% of all breast cancers (and even higher in older women) are hormone receptor–positive (Rakha et al, 2007; Morrison et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

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Long-Term Use of Tamoxifen Is Associated With a Decreased Subsequent Meningioma Risk in Patients With Breast Cancer: A Nationwide Population-Based Cohort Study

et al. 2019

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Background: Earlier studies have indicated a relatively higher risk of occurring meningioma among female breast cancer survivors and have suggested that tamoxifen might decrease this risk. The present study evaluated whether tamoxifen use in breast cancer patients can reduce the risk of meningioma. Methods: We designed a population-based cohort study by using data from the National Health Insurance system of Taiwan to assess this issue. Between January 1, 2000, and December 31, 2008, women with breast cancer and of age ≥20 years were included. They were divided into two groups: those who had not received tamoxifen therapy and those who had. The Cox’s proportion hazard regression analysis was conducted to estimate the effects of tamoxifen treatment and the subsequent meningioma risk. Results: We identified a total of 50,442 tamoxifen users and 30,929 non-tamoxifen users. Tamoxifen users had a borderline significantly lower overall risk of meningioma than non-tamoxifen users [adjusted hazard ratio (aHR) = 0.64, 95% confidence interval (95% CI) = 0.40–1.02]. A statistically significant difference was found in those patients with tamoxifen treatment duration longer than 1,500 days (aHR = 0.42, 95% CI = 0.19–0.91) or with cumulative dosage exceeding 26,320 mg (aHR = 0.44, 95% CI = 0.22–0.88). Furthermore, no statistically significant joint effect of aromatase inhibitors and tamoxifen on the occurrence of meningioma among breast cancer patients was seen. Conclusion: Tamoxifen users had a non-significantly (36%) lower risk of developing meningioma than did tamoxifen non-users; however, our data indicated that tamoxifen therapy is associated with a reduced meningioma risk for Taiwanese breast cancer patients receiving long duration or high cumulative dosage treatment with tamoxifen.

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Section: Discussioncontrasting

confidence: 69%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Long-Term Use of Tamoxifen Is Associated With a Decreased Subsequent Meningioma Risk in Patients With Breast Cancer: A Nationwide Population-Based Cohort Study

et al. 2019

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“…The higher incidence of meningiomas among women with previous breast cancer seems to be a fact, since recent papers identi ed a 26% higher meningioma incidence in this population 7 . Due to the reported link between BC and female hormones and also between meningioma and these hormones, it has been hypothesized that meningiomas and BCs may be linked 12 .…”

Section: Discussionmentioning

confidence: 99%

Analysis of the Meningiomas’ Hormonal Profile in Patients with Meningioma and Breast Cancer

Finger

Prevedello

Godoy

et al. 2023

32nd Annual Meeting North American Skull Base Society

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The objective of this study is to evaluate the meningioma`s hormone receptor expression in patients who presented synchronous or metachronous meningioma and breast cancer and compare its pro le to the non-breast cancer associated meningiomas described in the literature. MethodsThe authors conducted a retrospective descriptive study evaluating all cases of synchronous and metachronous meningiomas and breast cancer from January 1st, 1990 to December 31st, 2020. The study was approved by the Ethics Review Board. Variables related to meningioma (age and year of diagnosis, histological grade and subtype, topography, the presence of progesterone and/or estrogen receptors) and to breast cancer (age and year of diagnosis, the histological grade and subtype, the presence of progesterone and/or estrogen receptors) were collected on the hospital`s electronic health records. ResultsA total of 12 cases were included in the study, being 2 (17%) synchronous and 10 (83%) metachronous. The mean age at meningioma diagnosis was 60.58 (± 10,99). The most frequent intracranial topography was convexity and sphenoid wing meningiomas (25% each). Ten patients (83%) had grade 1 meningiomas and 2 patients (16.6%) presented with grade 2 meningiomas. Eleven cases of meningiomas expressed progesterone receptors (91.67%) while 3 cases expressed estrogen receptors (25%). One patient did not express hormonal receptor. ConclusionThe WHO histological analysis and steroid receptors pro le did not seem to be different in the meningiomas included in this sample when compared to the description of no-breast cancer associated meningiomas.

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“…Another possible reason for this correlation in incidence is suspected to be the usage of cranial imaging for staging and/ or follow-up, particularly among women with more advanced breast cancer. [ 21 ]…”

Section: Discussionmentioning

confidence: 99%

Meningioma as the host for metastatic breast cancer: A rare occurrence with important therapeutic impact

Hosseinzadeh

Ketabchi

Ahmadi

et al. 2021

Surgical Neurology International

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Background: Tumor-to-tumor metastasis is a rare condition. There are few reports of metastatic tumors within intracranial tumors, including meningiomas. Since some metastatic tumors have osteoblastic imaging pattern, it is not always easy to differentiate them from meningioma on preoperative studies. Case Description: A 60-year-old female referred to our center complaining about a progressive headache, nausea, and vomiting for the past month. She had a history of breast cancer treated with radical mastectomy (5 years ago) and adjuvant chemotherapy (until 1 year ago). Workups revealed a dural-based mass in the left temporobasal and midline subfrontal regions. Histopathological study showed breast cancer metastasis nests within the primary meningioma. Conclusion: As the diagnosis of metastatic nests inside a benign tumor, drastically alters postoperative adjuvant treatments, a high index of suspicion is needed evaluating tumors from patients with a history of systemic neoplasms.

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Meningioma in Breast Cancer Patients

Cited by 15 publications

References 40 publications

Long-Term Use of Tamoxifen Is Associated With a Decreased Subsequent Meningioma Risk in Patients With Breast Cancer: A Nationwide Population-Based Cohort Study

Long-Term Use of Tamoxifen Is Associated With a Decreased Subsequent Meningioma Risk in Patients With Breast Cancer: A Nationwide Population-Based Cohort Study

Analysis of the Meningiomas’ Hormonal Profile in Patients with Meningioma and Breast Cancer

Meningioma as the host for metastatic breast cancer: A rare occurrence with important therapeutic impact

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