Meningioma–primary brain lymphoma association

Buccoliero, Anna Maria; Taddei, Gian Luigi; Caldarella, Adele; Mennonna, P; Ammannati, Franco; Taddei, Antonio; Mariotti, Furio

doi:10.1111/j.1440-1789.2004.00570.x

Cited by 17 publications

(14 citation statements)

References 27 publications

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“…The first one suggests that meningioma development incites a glial inflammatory response which results in B-cell proliferation, and therefore lymphoma generation. [157] The second one proposes a two hit genetic model in which the meningioma serves as an oncogenic factor. [811] This postulate has been evaluated in the glioblastoma–meningioma concurrent lesions through immunohistochemical analysis that revealed a high p53 positivity rate for both lesions.…”

Section: Discussionmentioning

confidence: 99%

“…In the eight cases of reported synchronous meningioma–lymphomas, two were discovered at autopsy,[1710] two had delayed presentation of lymphoma after a meningioma diagnosis,[18] and three were simultaneous presentations. [25] Of the three reports of simultaneous lesions, only one of the cases was a truly simultaneous, contiguous meningioma–lymphoma.…”

Section: Introductionmentioning

confidence: 99%

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Meningioma interdigitated with primary central nervous system B-cell lymphoma: A case report and literature review

Gordon

Fallon²,

Riley³

2011

Surg Neurol Int

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Background:Simultaneous presentation of multiple primary central nervous system (CNS) malignancies is extremely rare. There have been only eight cases of meningiomas co-existing with primary cerebral lymphoma, reported in the literature.Case Description:We present a case of a patient who underwent surgical resection of an olfactory grove meningioma that was interdigitated with a primary CNS B-cell lymphoma. Following surgery, the patient was treated with high-dose methotrexate, and has no evidence of recurrence after 18 months.Conclusion:Because of the early recognition of these two distinct pathologies, the patient received directed adjuvant therapies, and has exceeded the survival of all other cases reported in the literature.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Meningioma interdigitated with primary central nervous system B-cell lymphoma: A case report and literature review

Gordon

Fallon²,

Riley³

2011

Surg Neurol Int

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“…The keywords used for this search were; 'pituitary adenoma ', 'supra sellar meningioma', 'multiple primary brain tumor' 'tuberculum sellae', 'collision tumors', 'CNS' and 'coexisting tumors'. Definition and epidemiology, considering MESH terminology and related references in the literature, there have been different descriptions used to define coexistence of more than one tumor; 'collision tumors' are those with infiltration of a tumor by another type of tumor while 'coincidental tumors are synchronous tumors of different histogenesis in contiguous or far from each other (15). We would like to suggest that the coexisting tumors in cases like ours are most probably of coincidental type rather collision tumors.…”

Section: Discussionmentioning

confidence: 99%

Coexisting Pituitary Adenoma and Suprasellar Meningioma: A Coincidence or Causation Effect? Report of Two Cases and Review of Literature

Mortazavi¹,

Shirani²,

Saeedinia³

et al. 2015

IrJNS

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Background and Importance:The coexistence of pituitary adenoma and another type of brain tumor is a very rare clinical scenario. Even though such a presentation can be an incidental event but the possible pathogenesis of coexistence of different lesions in the sella and suprasellar region has not yet been elucidated. Case Presentation: Two cases of concomitant sellar and suprasellar region tumors are reported. A 37-year-old lady with Prolactinoma and a suprasellar meningioma and a 42-year-old Acromegalic man with suprasellar meningioma and a pituitary adenoma (PA). Conclusion Both meningiomas were removed transcranially while the Prolactinoma could be managed medically and the growth hormone (GH) secreting adenoma was removed trans-sphenoidally. The visual problems and hormonal imbalances of both patients improved postoperatively and there has been no sign of recurrence of the lesions after a mean of five years follow up. The literature is reviewed on this topic and the possible pathogenesis and management protocol of similar lesions are discussed.

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“…The observation that a significant number of the reported cases had their tumoral localization in juxtaposition raises the possibility that one tumor may act as an irritating agent for the local proliferation and growth of the other [6,11,12]. A purely coincidental event has been suggested by others [6,11,12]. Surgical trauma, ionizing radiation and genetic factors may influence tumor development [4].…”

Section: Discussionmentioning

confidence: 99%