Meningococcal vaccine evolution

Bona, Gianni; Guidi, Carla

doi:10.7175/cmi.v6i2.627

Cited by 6 publications

(8 citation statements)

References 31 publications

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“…The invasive meningococcal disease (IMD) from Neisseria meningitidis is still a frequently fatal pathology. The bacterium currently counts 13 recognized serogroups, among which A, B, C, W135, and Y are the most frequently isolated in the case of illness (1).…”

Section: Introductionmentioning

confidence: 99%

Antimeningococcal Vaccination Coverage Among Healthcare Workers in an Italian University Hospital

Gattini¹,

Napoletano²,

Bonotti³

et al. 2021

Front. Public Health

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Introduction: Following an outbreak of meningococcal epidemic in 2015 and 2016 in Tuscany, we registered a higher demand for antimeningococcal vaccination (anti-Men ACWY) by Healthcare Workers of the University Hospital of Pisa [Azienda Ospedaliero Universitaria Pisana (AOUP)]. The purpose of this work is to analyze and discuss data on vaccination coverage resulting from this vaccination campaign.Materials and Methods: We conducted a monocentric study about anti-Men vaccination in the healthcare workers of the AOUP following the outbreak of meningococcal meningitis that occurred mainly in the population of the Tuscan provinces of Pisa, Pistoia, Prato, and Florence. The variables under examination were age, sex, educational qualification, and job profile. Department healthcare workers were vaccinated with two types of conjugated tetravalent vaccines for the A, C, Y, and W135 strains. Data were analyzed using the SPSS software.Results: The total population of the workers in AOUP was 7,188 subjects; the population considered in the study was 5,889. Between 2015 and 2017, a total of 2,423 subjects (41.1%) underwent anti-Men vaccination. Women, older HCWs, those with a lower educational qualification, doctors, and the HCWs of the maternal and child department, and imaging department recorded a statistically significant better vaccine compliance.Discussion: The AOUP, implementing the program of the Tuscany Region of vaccination against Neisseria meningitidis, has contributed to reduce the incidence of invasive meningococcal disease. Some critical issues remain in the compliance of some sections of the population, despite the high level of adherence recorded in this case, probably also due to the great media coverage of the event.

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Section: Introductionmentioning

confidence: 99%

Antimeningococcal Vaccination Coverage Among Healthcare Workers in an Italian University Hospital

Gattini¹,

Napoletano²,

Bonotti³

et al. 2021

Front. Public Health

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“…Neisseria meningitidis is one of the main pathogens causing sporadic or outbreak cases of bacterial meningitis worldwide (Jafri et al , 2013). As a vaccine-preventable disease, meningococcal meningitis has changed dramatically in terms of incidence and prevalent serogroups, with the expanding application of vaccines against specific N. meningitidis serogroups (Bona & Guidi, 2012; Jafri et al , 2013; Zhou et al , 2012). In China, since a polysaccharide vaccine against serogroup A was included in the routine immunization program in 1984, the incidence of meningococcal meningitis has decreased to less than 0.2 %.…”

Section: Introductionmentioning

confidence: 99%

Genetic diversity and clonal characteristics of ciprofloxacin-resistant meningococcal strains in China

Zhu

Fan

et al. 2014

Journal of Medical Microbiology

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The purpose of the present study was to identify the clonal characteristics and gyrA gene diversity of ciprofloxacin-resistant meningococcal strains in China. One hundred and forty-one ciprofloxacin-resistant and 103 ciprofloxacin-susceptible meningococcal strains were selected for multilocus sequence typing. Of these, 54 ciprofloxacin-resistant and 42 ciprofloxacinsusceptible strains were selected for gyrA gene sequencing. Of the three clonal complexes prevalent in China, serogroup A of ST-5 complex (CC5) and serogroup C/B strains of CC4821 had a high proportion of ciprofloxacin resistance, whereas CC11 serogroup W strains were all susceptible. Nucleotide and amino acid sequences of the gyrA gene among ciprofloxacinresistant strains showed more diversity than those among ciprofloxacin-susceptible strains. All ciprofloxacin-resistant strains had a T91I mutation and the ciprofloxacin-susceptible strains had no T91I mutation. Phylogenetic analysis showed that the gyrA gene sequences of CC4821 serogroup B/C strains, CC11 serogroup W, CC1 serogroup A, ciprofloxacin-susceptible CC5 serogroup A and reference strains had high similarity. By contrast, the ciprofloxacin-resistant CC5 serogroup A strains had a highly conserved gyrA gene sequence which was different (94.8 % similarity) from that in the above strains. The results of our investigation showed that the high proportion of ciprofloxacin resistance in Neisseria meningitidis is associated with certain sequence types (STs) or clonal complexes (CCs). The prevalence of certain CCs with a high proportion of ciprofloxacin resistance can facilitate the spread of ciprofloxacin resistance.

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“…Patients with immune deficiency such as anatomic or functional asplenia or low levels or dysfunction of the terminal components of complement or properdin proteins have a higher risk of developing IMD [12][13][14][15][16][17][18][19]. Patients with late complement component deficiency (LCCD) usually develop the disease at an older age than the general population and are most often infected with uncommon serogroups Y or W135 [20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Relationships Between Clinico-Epidemiological Patterns of Invasive Meningococcal Infections and Complement Deficiencies in French South Pacific Islands (New Caledonia)

et al. 2014

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Meningococcal vaccine evolution

Cited by 6 publications

References 31 publications

Antimeningococcal Vaccination Coverage Among Healthcare Workers in an Italian University Hospital

Antimeningococcal Vaccination Coverage Among Healthcare Workers in an Italian University Hospital

Genetic diversity and clonal characteristics of ciprofloxacin-resistant meningococcal strains in China

Relationships Between Clinico-Epidemiological Patterns of Invasive Meningococcal Infections and Complement Deficiencies in French South Pacific Islands (New Caledonia)

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