Meningococcemia: rare but life-threatening

Medeiros, Inês; Melo, Ana M.; Baptista, Vera; Ribeiro, Augusto

doi:10.1136/bcr-2018-226914

Cited by 5 publications

(5 citation statements)

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“…Meningococcemia needs to be diagnosed early and managed with antibiotics for treating infection and fuids along with vasopressors for the management of shock [3]. Our case was also managed with antibiotics, fuids, vasopressors, and blood components, which is similar to the case reported in Portugal [1]. Delay in diagnosis or management can increase the risk of mortality [3].…”

Section: Discussionsupporting

confidence: 73%

“…Our case is also an 11 months old infant. A case of meningococcemia reported from Portugal was also an infant [1], and an observational study from the UK showed the median age for meningococcal infection was two years [2]. Te disease can be rapidly fatal leading to death within hours, so it should be diagnosed as early as possible [8].…”

Section: Discussionmentioning

confidence: 99%

“…Meningococcal disease, caused by Neisseria meningitidis, is a rare disease with high morbidity and mortality in children [1]. It should be suspected when an ill-looking febrile child presents with a nonblanching purpuric rash [2,3].…”

Section: Introductionmentioning

confidence: 99%

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Meningococcemia in an 11 Months Old Infant

Shrestha

Karki²,

Khadka

et al. 2023

Case Reports in Infectious Diseases

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Meningococcemia is the infection of the blood caused by Neisseria meningitidis. Herein, we report a case of meningococcemia in an 11 months old infant who had a high-grade fever, nonblanching purpuric rash over the face and limbs, low blood pressure, tachycardia, and prolonged capillary refill time, but without neck rigidity and focal neurologic signs. He recovered after supportive care and treatment with antibiotics (intravenous ceftriaxone, vancomycin, and teicoplanin). Therefore, in a febrile, ill-looking child in shock with a nonblanching rash, meningococcal disease should be suspected. The study shows the importance of vaccination against meningococcal disease.

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Section: Discussionsupporting

confidence: 73%

Section: Discussionmentioning

confidence: 99%

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Meningococcemia in an 11 Months Old Infant

Shrestha

Karki²,

Khadka

et al. 2023

Case Reports in Infectious Diseases

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“…Early manifestations are often nonspecific, such as fever, headache, malaise, and nausea/vomiting. Although the characteristic petechial rash is a more specific finding, it is only observed in 45% to 65% of cases [16,17]. The petechial or purpuric eruption with an irregular outline and central gunmetal gray color may progress to purpura fulminans with severe DIC.…”

Section: • Meningococcemiamentioning

confidence: 99%

“…Meningococcal septicemia occurs in 20% of cases and is associated with poor outcomes. Meningiococcimeia is a clinical diagnosis that can be confirmed with blood culture; however, investigations should not delay treatment initiation [20,21].…”

Section: • Meningococcemiamentioning

confidence: 99%

Dermatologic Emergencies CME Part II: Infections and infection-related complications

Shanshal¹

2022

Our Dermatol Online

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The Diverse Spectrum of Invasive Meningococcal Disease in Pediatric and Adolescent Patients: Narrative Review of Cases and Case Series

Bobde,

Sohn,

Bekkat-Berkani

et al. 2024

Infect Dis Ther

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Introduction: Invasive meningococcal disease (IMD) is a potentially life-threatening disease caused by Neisseria meningitidis infection. We reviewed case reports of IMD from newborns, infants, children, and adolescents, and described the real-life clinical presentations, diagnoses, treatment paradigms, and clinical outcomes.Methods: PubMed and Embase were searched for IMD case reports on patients aged B 19 years published from January 2011 to March 2023 (search terms ''Neisseria meningitidis'' or ''invasive meningococcal disease '', and ''infant'', ''children'', ''paediatric'', pediatric'', or ''adolescent''). Results: We identified 97 publications reporting 184 cases of IMD, including 25 cases with a fatal outcome. Most cases were in adolescents aged 13-19 years (34.2%), followed by children aged 1-5 years (27.6%), children aged 6-12 years (17.1%), infants aged 1-12 months (17.1%), and neonates (3.9%). The most common disease-causing serogroups were W (40.2%), B (31.7%), and C (10.4%). Serogroup W was the most common serogroup in adolescents (17.2%), and serogroup B was the most common in the other age groups, including children aged 1-5 years (11.5%). The most common clinical presentations were meningitis (46.6%) and sepsis (36.8%). Conclusions: IMD continues to pose a threat to the health of children and adolescents. While this review was limited to case reports and is not reflective of global epidemiology, adolescents represented the largest group with IMD. Additionally, nearly half of the patients who died were adolescents, emphasizing the importance of monitoring and vaccination in this age group. Different infecting serogroups were predominant in different age groups, highlighting the usefulness of multivalent vaccines to provide the broadest possible

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Meningococcemia: rare but life-threatening

Cited by 5 publications

References 1 publication

Meningococcemia in an 11 Months Old Infant

Meningococcemia in an 11 Months Old Infant

Dermatologic Emergencies CME Part II: Infections and infection-related complications

The Diverse Spectrum of Invasive Meningococcal Disease in Pediatric and Adolescent Patients: Narrative Review of Cases and Case Series

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