Méningoencéphalite à Morganella morganii : à propos d’un cas

Ndiaye, M.; Sène, Matar; Sow, Adjaratou Dieynabou; Seck, Lala Bouna; Coulibaly, T; Diagne, N.S.; Touré, Kamadore; Diop, Amadou Gallo

doi:10.1007/s13149-010-0055-y

Cited by 9 publications

(4 citation statements)

References 11 publications

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“…Contrary to this study, Mahrouki et al () identified bla DHA‐1 in class‐1 integrons in M. morganii in clinical specimens collected between 2004 and 2009 in Tunis, Tunisia, which also harbored qnrA6 and aac ( 6' ) ‐Ib‐cr quinolone resistance determinants (Mahrouki et al ). Ndiaye et al () also reported on a M. morganii isolate from the cerebrospinal fluid of a 12‐year old boy with acute meningoencephalitis in Dakar, Senegal (Ndiaye et al ), confirming the presence of this opportunistic pathogen in African healthcare settings. Nevertheless, a whole‐genome analysis of M. morganii from Africa is non‐existent.…”

Section: Resultsmentioning

confidence: 81%

Genomic analysis of two drug‐resistant clinical Morganella morganii strains isolated from UTI patients in Pretoria, South Africa

Mbelle

Sekyere

Feldman

et al. 2019

Lett Appl Microbiol

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Morganella morganii is an opportunistic bacterial pathogen of the Enterobacteriaceae family that is occasionally isolated from clinical (animal and human) specimens with varying resistance profiles. Detailed genomic analyses of drug‐resistant M. morganii strains are relatively limited, particularly in Africa, which is also due to their relatively low isolation rates from clinical settings. Here we report on two multidrug‐resistant clinical M. morganii isolates from urine specimens of two hospitalized patients in South Africa who presented with urinary tract infections in 2013. The isolates, M006 and E042, were only susceptible to carbapenems, amikacin and tigecycline. One strain, M006, had a novel class 1 integron, ln1484, associated with aadA7, sul1and gcuD gene cassettes and a Col3M plasmid replicase gene. The ln1484 intI1:aadA7:sul1 genes were bracketed by a TnAs3 composite transposon while a tet(B) gene was found on an IS4 family transposon. The rare blaDHA‐4 and blaDHA‐1 AmpC β‐lactamase genes were identified on the isolates’ chromosome. The isolates were phylogenetically distant and closely related to other international strains, suggesting that they were not obtained from a single epidemiological source. Further molecular surveillance is necessary to establish the prevalence of these MDR strains in the tertiary hospital. Moreover antibiotic stewardship and antibiotic sensitivity testing of all clinical isolates should be undertaken after empirical treatment to inform tailored therapy as well as reduce escalation of resistance and associated morbidities and mortalities. Significance and Impact of the Study We report on the first clinical Morganella morganii draft genomes from Africa. The isolates were found in the urine of patients presenting with urinary tract infections (UTIs). Notably, they were resistant to important clinical antibiotics, including those used to treat UTIs. Due to the common occurrence of UTIs, particularly among pregnant women for whom drug options are limited, the presence of antibiotic‐resistant uropathogens such as M. morganii is a serious public health concern. We therefore characterized the resistance mechanisms and epidemiology of these isolates to provide further insights into their dissemination and background data for future studies.

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Section: Resultsmentioning

confidence: 81%

Genomic analysis of two drug‐resistant clinical Morganella morganii strains isolated from UTI patients in Pretoria, South Africa

Mbelle

Sekyere

Feldman

et al. 2019

Lett Appl Microbiol

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“…In a review of the literature, there are 12 prior reports of M. morganii intracranial infections, with all prior described cases being parenchymal abscesses or meningitis. [ 1 , 2 , 7 , 8 , 10 - 17 ] Here, we report the first case description of isolated SE caused by M. morganii .…”

Section: Discussionmentioning

confidence: 94%

“…[ 6 ] This bacterial species is only rarely associated with central nervous system infections, with only 12 documented cases of brain abscesses and meningitis caused by M. morganii . [ 1 , 2 , 7 , 8 , 10 - 17 ] Two of these reported patients had coexistent SE secondary to the primary infection, but isolated SE cause by M. morganii has not been previously reported [ Table 1 ]. Here, we present a case of an isolated SE caused by M. morganii in a previously healthy, immunocompetent 13-month-old female.…”

Section: Introductionmentioning

confidence: 99%

Subdural empyema caused by Morganella morganii

Bond¹,

Stadler²

2020

Surgical Neurology International

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Background: Morganella morganii is a species of Gram-negative enteric rod found in normal human gut flora. Pathologically, this most often presents as urinary tract infections, wound infections, and bacteremia. It is highly uncommon for M. morganii to be implicated in a central nervous system infection, with only 12 reported cases of parenchymal abscesses or meningitis. Case Description: A previously healthy 13-month-old female presented with fever of unknown origin and had a witnessed seizure during evaluation. A large left subdural fluid collection was identified, and the patient underwent emergent burr hole drainage and subdural drain placement. Cultures demonstrated M. morganii empyema, and she subsequently completed a course of directed antibiotics. Six months following surgery, she has no further clinical or radiographic evidence of infection, seizures, or neurological sequelae. Conclusion: We describe the first reported case of isolated subdural empyema caused by M. morganii. The child was successfully treated with the evacuation of the empyema and direct antibiotics with no lasting neurological injury.

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“…The mortality rate of the reported studies in the literature, including our case, was 27.8%. The most common presentation was meningitis, with 10 cases; 5 cases were isolated meningitis, 7 8 9 10 11 2 were combined with brain abscesses, 3 12 1 was combined with subdural empyema, 13 1 was combined with encephalitis, 14 and 1 was combined with sepsis. 15 The second most common presentation was brain abscess, with seven cases; five cases were isolated brain abscesses, 5 16 17 18 two cases were combined with meningitis, 3 12 and one case was combined with subdural empyema.…”

Section: Discussionmentioning

confidence: 99%

Rare Presentation of Morganella morganii Microorganism as Epidural and Subdural Empyema

Daoud,

Jarrar,

Ababneh

et al. 2023

Arquivos Brasileiros de Neurocirurgia: Brazilian Neurosurgery

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Background Morganella morganii is a gram-negative bacterium that rarely infects the central nervous system (CNS). Few reports described such an infection in the CNS. We present a case of extremely invasive M. morganii infection in the CNS. In addition, we performed a literature review of M. morganii infection in the CNS. Case report A 53-year-old male was admitted to the hospital due to fever, general weakness, and left-sided facial muscle twitching. He had a history of diabetes mellitus, hypertension, brain tumor, and epilepsy. Multiple left frontal scalp ulcers were revealed. In addition, a computed tomography (CT) scan and magnetic resonance imaging (MRI) revealed a left side epidural abscess and subdural empyema. Moreover, the patient had left frontal bone osteomyelitis. The next day, the patient underwent craniectomy, was transferred to the intensive care unit and started an empirical antibiotic course. Morganella morganii was identified from the infected scalp ulcers. On the 13th day, the patient passed away due to uncontrolled status epilepticus. Conclusion M. morganii can cause isolated or multiple types of CNS infections, including brain abscess, meningitis, and subdural empyema. The mortality rate may differ according to age and to the use of surgical evacuation.

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Méningoencéphalite à Morganella morganii : à propos d’un cas

Cited by 9 publications

References 11 publications

Genomic analysis of two drug‐resistant clinical Morganella morganii strains isolated from UTI patients in Pretoria, South Africa

Genomic analysis of two drug‐resistant clinical Morganella morganii strains isolated from UTI patients in Pretoria, South Africa

Subdural empyema caused by Morganella morganii

Rare Presentation of Morganella morganii Microorganism as Epidural and Subdural Empyema

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