Meniscal repair possibilities using bone morphogenetic protein-7

Forriol, Francisco; Ripalda, P.; Duart, Julio; Esparza, Raúl; Gortázar, Arancha R.

doi:10.1016/s0020-1383(14)70005-1

Cited by 18 publications

(11 citation statements)

References 48 publications

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“…Avascular tears [187] Fibrin-CTGF stimulates meniscal cell to repair inner zone meniscal defects Avascular tears [188] Serum, HA, TGF-β3 supplemented scaffold directed repair of meniscal tears Directed repair of meniscal tears [182] Non-viral gene transfer to meniscal cells and FGF-2 overexpressing meniscal cells FGF-2 transduced meniscal cells in alginate beads [190,191] VEGF stimulation of resident meniscal cells Avascular tears [194] TGF-β1 induction of meniscal cell proliferation and migration to a meniscal defect Micro wound assay system [195] OP-1 putty in punch biopsy meniscal holes 2 mm holes-inner meniscus [196] Gelatin hydrogel + FGF-2 Horizontal tears [192] HA-collagen composite + PRP 2 mm holes, implant [47,193] Type I collagen scaffold and infrapatellar fat pad…”

Section: Scaffolds Lesion and Study Type Referencesmentioning

confidence: 99%

“…FGF-2 over-expressing meniscal cells [190,191] and gelatin-FGF-2 scaffolds [192] also stimulated repair of inner meniscal defects. HA-collagen-PRP composites [47,193], VEGF [194], TGF-β1 [195] and OP-1 [196] also stimulated meniscal cells and MSCs to undertake repair of inner meniscal defects or punch biopsy wounds in menisci. The bioscaffolds used in meniscal repair or regenerative strategies have been extensively reviewed [197][198][199][200].…”

Section: Bioscaffolds Bioactive Substances and Bioadhesives And Menimentioning

confidence: 99%

See 1 more Smart Citation

Novel Approaches in Meniscal Repair Utilizing Mesenchymal Stem Cells, New Generation Bioscaffolds and Biological Adhesives as Cell Delivery Vehicles

Melrose¹

2019

Meniscus of the Knee - Function, Pathology and Management

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Mesenchymal stem cells (MSCs) have been widely applied in the repair of the knee-joint menisci which have a limited ability to undergo spontaneous repair. The menisci stabilise the knee-joint and are weight-bearing structures subjected to considerable tensional and compressive forces during flexion-extension and torsional loading of the knee. Traumatic loading of the knee-joint menisci can generate a number of lesions in the inner avascular meniscal regions. These have a limited capability of intrinsic repair and predispose the underlying articular cartilages to premature osteoarthritis. A number of strategies have therefore been developed for meniscal repair employing MSCs, bioscaffolds, hydrogels, biological glue cell delivery systems and agents which promote cell proliferation/matrix synthesis. Meniscal implants have also been developed in combination with the above procedures. It is important that meniscal defects be repaired not only to maintain kneejoint stability but also to prevent further degenerative changes in other knee joint tissues. Degenerative menisci contribute degradative proteinases and inflammatory mediators to the total synovial degradative proteinase pool. Partial or total surgical removal of the menisci is not a solution since this leads to premature osteoarthritis. Meniscal integrity needs to be maintained or repair strategies implemented in a timely manner to maintain knee joint function.

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Section: Scaffolds Lesion and Study Type Referencesmentioning

confidence: 99%

Section: Bioscaffolds Bioactive Substances and Bioadhesives And Menimentioning

confidence: 99%

Novel Approaches in Meniscal Repair Utilizing Mesenchymal Stem Cells, New Generation Bioscaffolds and Biological Adhesives as Cell Delivery Vehicles

Melrose¹

2019

Meniscus of the Knee - Function, Pathology and Management

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“…But most patients undergo magnetic resonance imaging (MRI) before arthroscopy, although MRI results are not always consistent with arthroscopic findings 12 . Chambers et al 13 compared the MRI meniscal images with arthroscopy, finding that MRI scanning was 90.5% sensitive, 89.5% specific and 90.1% accurate.…”

Section: Meniscus Tear Surgery and Meniscus Replacementmentioning

confidence: 99%

“…Meniscal repair is a priority after the instability has been corrected, in peripheral lesions and in young, very active patients. The most successful repairs are usually in younger patients who have an acute, vertical tear in the vascular portion of the meniscus 10 , where repairs are often performed in order to decrease the chance of the patient developing OA 12,31,32 .…”

Section: Meniscus Repair and Replacementmentioning

confidence: 99%

Meniscus tear surgery and meniscus replacement

Vaquero

Forriol

2016

MLTJ

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SummaryObjective: the menisci are easily injured and difficult to repair. The aim of this study was to analyze the current state of meniscal surgery aimed at preserving morphology and conserving the biomechanics of the knee to prevent joint degeneration. Methodology: a search of the electronic medical literature database Medline was conducted, from http://www.ncbi.nlm.nih.gov/pubmed. The search was not limited by language. Candidate articles were identified by searching for those that included the keywords meniscus, surgery, suture, implant, allograft. The limits were included for clinical research and clinical trials. Basic research was not included. The studies selected were evaluated and classified in three different categories: basic science, reconstruction (suture and meniscectomy) and implants (scaffolds and allograft). Results: the consequences of meniscectomy performed at a young age can lead to a joint cartilage degeneration twenty years later. There are few surgical options for the repair of meniscal injuries in order both to preserve the meniscus and to ensure the long term survival of the knee joint, meniscectomy, repair, suturing the tear, or reconstruction, when a meniscal allograft or synthetic substitute is used to replace the meniscus, but the biomechanical properties of the native meniscus are not reproduced entirely by the scaffolds that exist today.Conclusion: therapies that successfully repair or replace the meniscus are therefore likely to prevent or delay osteoarthritis progression.

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“…Knee arthroscopy is the gold standard in diagnosis and simultaneous treatment of meniscus disorders. But most patients undergo magnetic resonance imaging (MRI) before arthroscopy, although MRI results are not always consistent with arthroscopic findings 12 . Chambers et al 13 compared the MRI meniscal images with arthroscopy, finding that MRI scanning was 90.5% sensitive, 89.5% specific and 90.1% accurate.…”

Section: Introductionmentioning

confidence: 99%

Meniscus tear surgery and meniscus replacement

Vaquero

Forriol

2019

Muscle Ligaments and Tendons J

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Objective: the menisci are easily injured and difficult to repair. The aim of this study was to analyze the current state of meniscal surgery aimed at preserving morphology and conserving the biomechanics of the knee to prevent joint degeneration. Methodology: a search of the electronic medical literature database Medline was conducted, from http://www.ncbi.nlm.nih.gov/pubmed. The search was not limited by language. Candidate articles were identified by searching for those that included the keywords meniscus, surgery, suture, implant, allograft. The limits were included for clinical research and clinical trials. Basic research was not included. The studies selected were evaluated and classified in three different categories: basic science, reconstruction (suture and meniscectomy) and implants (scaffolds and allograft). Results: the consequences of meniscectomy performed at a young age can lead to a joint cartilage degeneration twenty years later. There are few surgical options for the repair of meniscal injuries in order both to preserve the meniscus and to ensure the long term survival of the knee joint, meniscectomy, repair, suturing the tear, or reconstruction, when a meniscal allograft or synthetic substitute is used to replace the meniscus, but the biomechanical properties of the native meniscus are not reproduced entirely by the scaffolds that exist today.Conclusion: therapies that successfully repair or replace the meniscus are therefore likely to prevent or delay osteoarthritis progression.

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Meniscal repair possibilities using bone morphogenetic protein-7

Cited by 18 publications

References 48 publications

Novel Approaches in Meniscal Repair Utilizing Mesenchymal Stem Cells, New Generation Bioscaffolds and Biological Adhesives as Cell Delivery Vehicles

Novel Approaches in Meniscal Repair Utilizing Mesenchymal Stem Cells, New Generation Bioscaffolds and Biological Adhesives as Cell Delivery Vehicles

Meniscus tear surgery and meniscus replacement

Meniscus tear surgery and meniscus replacement

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