Meniscal tears associated with anterior cruciate ligament injury

Hagino, Tetsuo; Ochiai, Satoshi; Senga, Shinya; Yamashita, Takashi; Wako, Masanori; Ando, Takashi; Haro, Hirotaka

doi:10.1007/s00402-015-2309-4

Cited by 168 publications

(133 citation statements)

References 13 publications

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“…Moreover, the use of tendon or ligament offers the advantage of isolating cells from a site other than an injured meniscus, which may improve patient outcomes. In ACL injuries, associated menisci tears are seen in approximately half of the cases 22,23 . As a consequence, in these cases, the remnants of the torn ACL can be harvested for cells which can then be combined in co-culture with articular chondrocytes towards engineering a new autologous knee meniscus.…”

Section: Discussionmentioning

confidence: 99%

Tendon and ligament as novel cell sources for engineering the knee meniscus

Hadidi

Paschos

Huang

et al. 2016

Osteoarthritis and Cartilage

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Objective The application of cell-based therapies in regenerative medicine is hindered by the difficulty of acquiring adequate numbers of competent cells. For the knee meniscus in particular, this may be solved by harvesting tissue from neighboring tendons and ligaments. In this study, we have investigated the potential of cells from tendon and ligament, as compared to meniscus cells, to engineer scaffold-free self-assembling fibrocartilage. Method Self-assembling meniscus-shaped constructs engineered from a co-culture of articular chondrocytes and either meniscus, tendon, or ligament cells were cultured for 4 weeks with TGF-β1 in serum-free media. After culture, constructs were assessed for their mechanical properties, histological staining, gross appearance, and biochemical composition including cross-link content. Correlations were performed to evaluate relationships between biochemical content and mechanical properties. Results In terms of mechanical properties as well as biochemical content, constructs engineered using tenocytes and ligament fibrocytes were found to be equivalent or superior to constructs engineered using meniscus cells. Furthermore, cross-link content was found to be correlated with engineered tissue tensile properties. Conclusion Tenocytes and ligament fibrocytes represent viable cell sources for engineering meniscus fibrocartilage using the self-assembling process. Due to greater cross-link content, fibrocartilage engineered with tenocytes and ligament fibrocytes may maintain greater tensile properties than fibrocartilage engineered with meniscus cells.

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Section: Discussionmentioning

confidence: 99%

Tendon and ligament as novel cell sources for engineering the knee meniscus

Hadidi

Paschos

Huang

et al. 2016

Osteoarthritis and Cartilage

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“…The association of meniscal tears with ligamentous injuries has been most extensively studied in the setting of ACL tears. A recent study demonstrated meniscal tears in 72% of patients with acute ACL tears and 85% with chronic ACL tears (26). In acute ACL tears, the lateral meniscus alone was involved in 70%, the medial meniscus alone was involved in 10%, and both menisci were involved in 20%.…”

Section: State Of the Art: Athletic Injuries Of Knee Ligaments And Mementioning

confidence: 98%

“…In acute ACL tears, the lateral meniscus alone was involved in 70%, the medial meniscus alone was involved in 10%, and both menisci were involved in 20%. In contrast, in chronic ACL tears, the lateral meniscus alone was involved in 34%, the medial meniscus alone was involved in 25%, and both menisci were involved in 41% (26). Ninety percent of peripheral vertical longitudinal meniscal tears are seen in patients with ACL tears, and the presence of a peripheral vertical meniscal tear should raise suspicion for an associated ACL tear (27) (Fig 3).…”

Section: State Of the Art: Athletic Injuries Of Knee Ligaments And Mementioning

confidence: 99%

Imaging of Athletic Injuries of Knee Ligaments and Menisci: Sports Imaging Series

Naraghi¹,

White²

2016

Radiology

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Acute knee injuries are a common source of morbidity in athletes and if overlooked may result in chronic functional impairment. Magnetic resonance (MR) imaging of the knee has become the most commonly performed musculoskeletal MR examination and is an indispensable tool in the appropriate management of the injured athlete. Meniscal and ligamentous tearing are the most frequent indications for surgical intervention in sports injuries and an understanding of the anatomy, biomechanics, mechanisms of injury, and patterns of injury are all critical to accurate diagnosis and appropriate management. These will be discussed in reference to meniscal tears and injuries of the cruciate ligaments as well as injuries of the posterolateral and posteromedial corners of the knee. (©) RSNA, 2016.

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“…The offset in external rotation of the femur after ACL transection causes changes in the contact point on the tibia which may attribute to the increase in the number of knees with common profiles in the central portion of the medial meniscus, the increased profile area from Profile 3 to 3′ and the identification of the new profile on the lateral plateau. Moreover, such changes in contact stress profiles in areas covered by the meniscus correspond to the increased incidence of medial meniscus damage in chronic ACL deficient knees (Bellabarba et al, 1997; Hagino et al, 2015). The altered rotational mechanics can lead to significant cartilage loss in the posterior medial tibial plateau, observed in Andriacchi et al (2006), and offloading of areas that were highly loaded (Andriacchi et al, 2006; Andriacchi and Mundermann, 2006; Chaudhari et al, 2008) – as was observed with fewer knees identifying with Profile 2 to 2′ after ACL transection.…”

Section: Discussionmentioning

confidence: 99%

Loss of ACL function leads to alterations in tibial plateau common dynamic contact stress profiles

Chen

Wang

Warren

et al. 2017

Journal of Biomechanics

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It has been suggested that the repetitive nature of altered joint tissue loading which occurs after anterior cruciate ligament (ACL) rupture can contribute to the development of osteoarthritis (OA). However, changes in dynamic knee joint contact stresses after ACL rupture have not been quantified for activities of daily living. Our objective was to characterize changes in dynamic contact stress profiles that occur across the tibial plateau immediately after ACL transection. By subjecting sensor-augmented cadaveric knees to simulated gait, and analyzing the resulting contact stress profiles using a normalized cross-correlation algorithm, we tested the hypothesis that common changes in dynamic contact stress profiles exist after ACL injury. Three common profiles were identified in intact knees, occurring on the: I) posterior lateral plateau, II) posterior medial plateau, and III) central region of the medial plateau. In ACL-transected knees, the magnitude and shape of the common dynamic stress profiles did not change, but their locations on the tibial plateau and the number of knees identified for each profile changed. Furthermore, in the ACL transected knees, a unique common contact stress profile was identified in the posterior region of the lateral plateau near the tibial spine. This framework can be used to understand the regional and temporal changes in joint mechanics after injury.

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Meniscal tears associated with anterior cruciate ligament injury

Abstract: The incidence of meniscal tear associated with ACL injury is higher in chronic cases; the number of medial meniscal tears is particularly high, many of which require meniscectomy. Early ACL reconstruction is recommended also for the prevention of secondary meniscal tear.

Cited by 168 publications

References 13 publications

Tendon and ligament as novel cell sources for engineering the knee meniscus

Tendon and ligament as novel cell sources for engineering the knee meniscus

Imaging of Athletic Injuries of Knee Ligaments and Menisci: Sports Imaging Series

Loss of ACL function leads to alterations in tibial plateau common dynamic contact stress profiles

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