Meniscus-enabled Projection Stereolithography (MAPS)

Kunwar, Puskal; Poudel, Arun; Aryal, Ujjwal; Xie, Rui; Geffert, Zachary J; Wittmann, Hans-Peter; Chiang, Tsung Han; Maye, Mathew M.; Li, Zhong’an; Soman, Pranav

doi:10.1101/2023.06.12.544584

Cited by 6 publications

(3 citation statements)

References 42 publications

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“…This can be attributed to volume shrinkage (described in Section 3.3) and capillary action of the resin liquid. This phenomenon of meniscus formation in photosensitive resin has also been reported earlier (Kunwar et al, 2023;Zhong and Shan, 2014). However, for this process, it is necessary to compensate for the total sagging to get a flat surface at the top.…”

Section: Fabrication Processsupporting

confidence: 72%

Optimizing time in additive manufacturing: a hybrid fused deposition modeling and photopolymerization approach

Singh,

Verma

2024

RPJ

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Purpose This study aims to address the challenge of reducing the build time of a fused deposition modeling (FDM) system while maintaining part strength, proposing a hybrid technique combining photopolymerization and FDM. Design/methodology/approach For developing the hybrid system, a standard FDM machine was modified to incorporate necessary components so that the whole system can be operated with a single interface; further, the samples were fabricated with conventional and modified process to evaluate the efficacy of the developed system, to determine the extent of time reduction that the proposed methodology can obtain, additionally different sort of 3D models were selected and their build time was compared. Findings The modified hybrid mechanism can successfully fabricate parts with a modified G-code. The simulation of the technique shows that a reduction of 34%–87% can be achieved for simpler models such as cube while a reduction ranging from 30.6%–87.8% was observed for complex models. An increase in strength of 6.58%, 11.51% and 37.32% was observed in X, Y and Z directions, along with a significant increase in toughness as compared with FDM parts for parts fabricated with the developed mechanism. Practical implications The modified mechanism could be used for fast fabrication purposes, which could be very useful for serving situations such as emergency health care, rapid tooling. Originality/value This research contributes a novel hybrid technique for additive manufacturing, offering a substantial reduction in build time without compromising mechanical properties, even increasing them.

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Section: Fabrication Processsupporting

confidence: 72%

Optimizing time in additive manufacturing: a hybrid fused deposition modeling and photopolymerization approach

Singh,

Verma

2024

RPJ

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“…Inkjet bioprinting is non-contact method to print tissue analogs with high cell viability and scalability, however challenges related to printing thick tissues with bioinks properties within a narrow viscosity range as limited it use in the field [23,24]. Among the many bioprinting methods, digital light projection (DLP) based bioprinting methods are capable of printing both acellular and cell-laden scalable 3D architecture at high resolutions, speeds, and overall fidelity (table S1) [3,4,7,[25][26][27][28][29]. These methods use a liquid crystal display or a digital micromirror device (DMD) to generate digital masks that can spatially pattern and project light onto a vat or reservoir filled with liquid photo-sensitive bioink of resin to print 3D constructs via rapid crosslinking in a layer-by-layer manner [30][31][32].…”

Section: Introductionmentioning

confidence: 99%

Droplet bioprinting of acellular and cell-laden structures at high-resolutions

Kunwar,

Aryal,

Poudel

et al. 2024

Biofabrication

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Advances in Digital Light Processing (DLP) based (bio) printers have made printing of intricate structures at high resolution possible using a wide range of photosensitive bioinks. A typical setup of a DLP bioprinter includes a vat or reservoir filled with liquid bioink, which presents challenges in terms of cost associated with bioink synthesis, high waste, and gravity-induced cell settling, contaminations, or variation in bioink viscosity during the printing process. Here, we report a vat-free, low-volume, waste-free droplet bioprinting method capable of rapidly printing 3D soft structures at high resolution using model bioinks. A multiphase many-body dissipative particle dynamics (mDPD) model was developed to simulate the dynamic process of droplet-based DLP printing and elucidate the roles of surface wettability and bioink viscosity. Process variables such as light intensity, photo-initiator concentration, and bioink formulations were optimized to print 3D soft structures (~0.4 to 3 kPa) with an XY resolution of 38 ± 1.5 μm and Z resolution of 237±5.4 µm. To demonstrate its versatility, droplet bioprinting was used to print a range of acellular 3D structures such as a lattice cube, a Mayan pyramid, a heart-shaped structure, and a microfluidic chip with endothelialized channels. Droplet bioprinting, performed using model C3H/10T1/2 cells, exhibited high viability (90%) and cell spreading. Additionally, microfluidic devices with internal channel network lined with endothelial cells showed robust monolayer formation while osteoblast-laden constructs showed mineral deposition upon osteogenic induction. Overall, droplet bioprinting could be a low-cost, no-waste, easy-to-use, method to make customized bioprinted constructs for a range of biomedical applications.

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“…[1][2][3][4][5][6][7] Among the many bioprinting methods, digital light projection (DLP) based bioprinting methods are capable of printing both acellular and cell-laden 3D architecture at high resolutions, speeds, and overall fidelity. [3,4,[7][8][9][10] These methods use a liquid crystal display or a digital micromirror device (DMD) to generate digital masks that can spatially pattern and project light onto a vat or reservoir filled with liquid photo-sensitive bioink to print 3D constructs via rapid crosslinking in a layer-by-layer manner. [11][12][13] Depending on the optical setups and bioink formulations, structures with a high XY resolution of 50-100 µm are possible.…”

Section: Introductionmentioning

confidence: 99%

Droplet bioprinting of acellular and cell-laden structures at high-resolutions

Kunwar,

Aryal,

Poudel

et al. 2023

Preprint

Self Cite

View full text Add to dashboard Cite

Advances in Digital Light Processing (DLP) based (bio) printers have made printing of intricate structures at high resolution possible using a wide range of photosensitive bioinks. A typical setup of a DLP bioprinter includes a vat or reservoir filled with liquid bioink, which presents challenges in terms of cost associated with bioink synthesis, high waste, and gravity-induced cell settling, contaminations, or variation in bioink viscosity during the printing process. Here, we report a vat-free, low-volume, waste-free droplet bioprinting method capable of rapidly printing 3D soft structures at high resolution using model bioinks. A multiphase many-body dissipative particle dynamics (mDPD) model was developed to simulate the dynamic process of droplet-based DLP printing and elucidate the roles of surface wettability and bioink viscosity. Process variables such as light intensity, photo-initiator concentration, and bioink formulations were optimized to print 3D soft structures (∼0.4 to 3 kPa) with an XY resolution of 38 ± 1.5 μm and Z resolution of 237±5.4 μm. To demonstrate its versatility, droplet bioprinting was used to print a range of acellular 3D structures such as a lattice cube, a Mayan pyramid, a heart-shaped structure, and a microfluidic chip with endothelialized channels. Droplet bioprinting, performed using model C3H/10T1/2 cells, exhibited high viability (90%) and cell spreading. Additionally, microfluidic devices with internal channel network lined with endothelial cells showed robust monolayer formation while osteoblast-laden constructs showed mineral deposition upon osteogenic induction. Overall, droplet bioprinting could be a low-cost, no-waste, easy-to-use, method to make customized bioprinted constructs for a range of biomedical applications.

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Meniscus-enabled Projection Stereolithography (MAPS)

Cited by 6 publications

References 42 publications

Optimizing time in additive manufacturing: a hybrid fused deposition modeling and photopolymerization approach

Optimizing time in additive manufacturing: a hybrid fused deposition modeling and photopolymerization approach

Droplet bioprinting of acellular and cell-laden structures at high-resolutions

Droplet bioprinting of acellular and cell-laden structures at high-resolutions

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