2023
DOI: 10.1159/000530205
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Menopausal Hormone Therapy and the Breast: A Review of Clinical Studies

Abstract: Background: Women in the peri- or postmenopause can experience symptoms related to the gradual degradation of ovarian function. Hormone replacement therapy (HRT) is the most effective therapy to treat common menopausal symptoms such as hot flashes and vaginal discomfort. However, safety concerns have been raised revolving among others also around the risk of breast cancer. Methods: This article is based on a selective literature search for relevant studies regarding HRT use and the risk of breast cancer in ge… Show more

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Cited by 3 publications
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“…In menopausal females, HRT is reported to inhibit/prevent OP [154,155], metabolic syndromes [156], and loss of intervertebral disc height [157], as well as not posing a risk for breast cancer [158], but evidence for a role in protection at the level of OA [159], CVD [160,161] and dementia/Alzheimer's disease [162] is still controversial via mixed results of studies over the past 25 years.…”
Section: During Menopause and During Post-menopausal Interventionsmentioning
confidence: 99%
“…In menopausal females, HRT is reported to inhibit/prevent OP [154,155], metabolic syndromes [156], and loss of intervertebral disc height [157], as well as not posing a risk for breast cancer [158], but evidence for a role in protection at the level of OA [159], CVD [160,161] and dementia/Alzheimer's disease [162] is still controversial via mixed results of studies over the past 25 years.…”
Section: During Menopause and During Post-menopausal Interventionsmentioning
confidence: 99%