OBJECTIVE
To estimate the duration of moderate-to-severe menopausal hot flushes and identify potential risk factors for hot flush duration.
METHODS
The Penn Ovarian Aging Study cohort was followed for 13 years. Hot flushes were evaluated at 9-month to 12-month intervals through in-person interviews. The primary outcome was the duration of moderate to severe hot flushes, estimated by survival analysis (N=259). Potential risk factors included menopausal stage, age, race, reproductive hormone levels, body mass index (BMI) and current smoking. A secondary analysis included women who reported any hot flushes (N=349).
RESULTS
The median duration of moderate to severe hot flushes was 10.2 years and was strongly associated with menopausal stage at onset. Hot flushes that commenced near entry into the menopause transition had a median duration >greater than 11.57 years; onset in the early transition stage had a median duration of 7.35 years (95% CI 4.94, 8.89), P<0.001); and onset in the late transition to postmenopausal stages had a median duration of 3.84 years (95% CI: 1.77, 5.52), P<0.001. The most common ages at onset of moderate-to-severe hot flushes were 45–49 years (median duration 8.1 years; 95% CI 5.12, 9.28). African American women had a longer duration of hot flushes than white women in adjusted analysis.
CONCLUSIONS
The median duration of hot flushes considerably exceeded the time frame that is generally accepted in clinical practice. The identified risk factors, particularly menopausal stage, race, and BMI, are important to consider in individualizing treatment and evaluating the risk to benefit ratio of hormones and other therapies.